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Structure of lineage IV Lassa virus glycoprotein complex (strain Josiah)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ejd
Q-score: 0.373
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
Structure of lineage II Lassa virus glycoprotein complex (strain NIG08-A41)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8eje
Q-score: 0.391
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Glycoprotein gp1 (28 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
Structure of lineage V Lassa virus glycoprotein complex (strain Soromba-R)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8ejf
Q-score: 0.355
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Glycoprotein gp2 (44 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein gp1 (29 kDa, Protein from Lassa mammarenavirus)
Structure of lineage VII Lassa virus glycoprotein complex (strain Togo/2016/7082)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8ejg
Q-score: 0.429
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein gp1 (22 kDa, Protein from Lassa mammarenavirus)
Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8ejh
Q-score: 0.406
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- Alpha-d-mannopyranose (180 Da, Ligand)
- 12.1f fab heavy chain (13 kDa, Protein from Homo sapiens)
- Lassa mammarenavirus gpc (425 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- 12.1f fab light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lassa virus glycoprotein complex (Josiah) bound to 19.7E Fab
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8eji
Q-score: 0.39
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- 19.7e fab heavy chain (13 kDa, Protein from Homo sapiens)
- 19.7e fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa mammarenavirus gpc (325 kDa, Complex from Lassa mammarenavirus)
Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8ejj
Q-score: 0.506
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- S370.7 light chain fab (11 kDa, Protein from Homo sapiens)
- S370.7 heavy chain fab (14 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Lassa mammarenavirus gpc (425 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein gp1 (22 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.97 Å
EM Method: Single-particle
Fitted PDBs: 7sgd
Q-score: 0.366
Brouwer PJM, Antanasijevic A, Ronk AJ, Muller-Krauter H, Watanabe Y, Claireaux M, Perrett HR, Bijl TPL, Grobben M, Umotoy JC, Schriek AI, Burger JA, Tejjani K, Lloyd NM, Steijaert TH, van Haaren MM, Sliepen K, de Taeye SW, van Gils MJ, Crispin M, Strecker T, Bukreyev A, Ward AB, Sanders RW
Cell Host Microbe (2022) 30 pp. 1759- [ Pubmed: 36400021 DOI: doi:10.1016/j.chom.2022.10.018 ]
Lassa virus glycoprotein construct (Josiah GPC-I53-50A) in complex with LAVA01 antibody
Resolution: 4.41 Å
EM Method: Single-particle
Fitted PDBs: 7sgf
Q-score: 0.292
Brouwer PJM, Antanasijevic A, Ronk AJ, Muller-Krauter H, Watanabe Y, Claireaux M, Perrett HR, Bijl TPL, Grobben M, Umotoy JC, Schriek AI, Burger JA, Tejjani K, Lloyd NM, Steijaert TH, van Haaren MM, Sliepen K, de Taeye SW, van Gils MJ, Crispin M, Strecker T, Bukreyev A, Ward AB, Sanders RW
Cell Host Microbe (2022) 30 pp. 1759- [ Pubmed: 36400021 DOI: doi:10.1016/j.chom.2022.10.018 ]
- Gpc-i53-50a (73 kDa, Protein from Lassa mammarenavirus)
- Lava01 mab - light chain (12 kDa, Protein from Oryctolagus cuniculus)
- Lava01 mab - heavy chain (15 kDa, Protein from Oryctolagus cuniculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa virus glycoprotein construct(josiah gpc-i53-50a) in complex with lava01 antibody (as fab fragment) (Complex from Lassa mammarenavirus)
AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 7zlk
Q-score: 0.362
van Schooten J, Schorcht A, Farokhi E, Umotoy JC, Gao H, van den Kerkhof TLGM, Dorning J, Rijkhold Meesters TG, van der Woude P, Burger JA, Bijl T, Ghalaiyini R, Torrents de la Pena A, Turner HL, Labranche CC, Stanfield RL, Sok D, Schuitemaker H, Montefiori DC, Burton DR, Ozorowski G, Seaman MS, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2022) 18 pp. e1010945-e1010945 [ Pubmed: 36395347 DOI: doi:10.1371/journal.ppat.1010945 ]
- Amc009 sosipv5.2 in complex with fabs acs114 and acs122 (17 MDa, Complex from Human immunodeficiency virus 1)
- Acs114 light chain (12 kDa, Protein from Homo sapiens)
- Acs122 heavy chain (13 kDa, Protein from Homo sapiens)
- Acs122 light chain (11 kDa, Protein from Homo sapiens)
- Amc009 sosipv5.2 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amc009 sosipv5.2 envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Acs114 heavy chain (13 kDa, Protein from Homo sapiens)