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KS + AT di-domain of polyketide synthase 13 in Mycobacterium tuberculosis
Johnston HE, Batt SM, Brown AK, Savva CG, Besra GS, Futterer K
To Be Published
- Subunit of pks13 (187 kDa, Complex from Mycobacterium tuberculosis)
- Polyketide synthase pks13 (186 kDa, Protein from Mycobacterium tuberculosis H37Rv)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8r6u
Q-score: 0.565
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) [ DOI: doi:10.1093/nar/gkae330 Pubmed: 38709882 ]
- Rna primer tail-end (5 kDa, RNA from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- Magnesium ion (24 Da, Ligand)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*cp*up*up*up*gp*up*gp*u)-3') (8 kDa, RNA from SFTS virus AH12)
- Rna primer (6 kDa, RNA from SFTS virus AH12)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8r6w
Q-score: 0.44
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) [ DOI: doi:10.1093/nar/gkae330 Pubmed: 38709882 ]
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*cp*ap*g)-3') (6 kDa, RNA from SFTS virus AH12)
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*cp*up*up*up*gp*up*gp*u)-3') (8 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(*ap*cp*ap*c)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(*(m7g)*ap*ap*a)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8r6y
Q-score: 0.456
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) [ DOI: doi:10.1093/nar/gkae330 Pubmed: 38709882 ]
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*cp*ap*g)-3') (6 kDa, RNA from SFTS virus AH12)
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- 5'-o-[(s)-hydroxy{[(s)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine (483 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*ap*ap*ap*up*gp*u)-3') (6 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(p*ap*cp*a)-3') (918 Da, RNA from SFTS virus AH12)
- Rna (5'-r(*(m7g)*ap*ap*a)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
E. coli DNA gyrase bound to a DNA crossover
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8qdx
Q-score: 0.451
Vayssieres M, Marechal N, Yun L, Lopez Duran B, Murugasamy NK, Fogg JM, Zechiedrich L, Nadal M, Lamour V
Science (2024) 384 pp. 227-232 [ DOI: doi:10.1126/science.adl5899 Pubmed: 38603484 ]
- Dna minicircle (36 kDa, DNA from synthetic construct)
- E. coli dna gyrase in complex with dna minicircles (745 kDa, Complex)
- Dna gyrase subunit a (97 kDa, Protein from Escherichia coli)
- E. coli dna gyrase (Complex from Escherichia coli)
- Dna minicircle (35 kDa, DNA from synthetic construct)
- Dsdna minicircles (Complex from synthetic construct)
- Dna gyrase subunit b (90 kDa, Protein from Escherichia coli)
E. coli DNA gyrase bound to a linear part of a DNA minicircle
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8qqs
Q-score: 0.519
Vayssieres M, Marechal N, Yun L, Lopez Duran B, Murugasamy NK, Fogg JM, Zechiedrich L, Nadal M, Lamour V
Science (2024) 384 pp. 227-232 [ DOI: doi:10.1126/science.adl5899 Pubmed: 38603484 ]
- Dna (30-mer) (9 kDa, DNA from synthetic construct)
- E. coli dna gyrase in complex with dsdna minicircles (745 kDa, Complex)
- Dna gyrase subunit a (97 kDa, Protein from Escherichia coli)
- E. coli dna gyrase (Complex from Escherichia coli)
- Dsdna minicircles (Complex from synthetic construct)
- Dna gyrase subunit b (90 kDa, Protein from Escherichia coli)
- Dna (30-mer) (9 kDa, DNA from synthetic construct)
Structure of the formin Cdc12 bound to the barbed end of phalloidin-stabilized F-actin.
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8rtt
Q-score: 0.444
Oosterheert W, Boiero Sanders M, Funk J, Prumbaum D, Raunser S, Bieling P
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin, cytoplasmic 1, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Complex of the dimeric fh2 domain of s. pombe cdc12 bound to the barbed end of phalloidin stabilized f-actin. (Complex)
- Magnesium ion (24 Da, Ligand)
- Phalloidin. (Complex from Amanita phalloides)
- Dimeric fh2 domain of s. pombe cdc12 (Complex from Schizosaccharomyces pombe)
- Cell division control protein 12 (48 kDa, Protein from Schizosaccharomyces pombe)
- Phalloidin (808 Da, Protein from Amanita phalloides)
- Actin filament (Complex from Homo sapiens)
Resolution: 6.25 Å
EM Method: Single-particle
Fitted PDBs: 8rty
Q-score: 0.17
Oosterheert W, Boiero Sanders M, Funk J, Prumbaum D, Raunser S, Bieling P
Science (2024) 384 pp. eadn9560-eadn9560 [ Pubmed: 38603491 DOI: doi:10.1126/science.adn9560 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Profilin-1-s29c/s71m (Complex from Homo sapiens)
- Profilin-1 (15 kDa, Protein from Homo sapiens)
- Actin-formin-profilin ring complex: the phalloidin-stabilized f-actin barbed end bound by dimeric-cdc12 and profilin-s71m. (Complex)
- Dimeric fh1fh2 domain of s. pombe cdc12 (Complex from Schizosaccharomyces pombe)
- Methylated-dna--protein-cysteine methyltransferase,cell division control protein 12 (77 kDa, Protein from Schizosaccharomyces pombe)
- Phalloidin (amanita phalloides) (808 Da, Protein from Amanita phalloides)
- Phalloidin (Complex from Amanita phalloides)
- Actin, cytoplasmic 1, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Actin filament (Complex from Homo sapiens)
Structure of the F-actin barbed end bound by formin mDia1
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8ru2
Q-score: 0.362
Oosterheert W, Boiero Sanders M, Funk J, Prumbaum D, Raunser S, Bieling P
Science (2024) 384 pp. eadn9560-eadn9560 [ Pubmed: 38603491 DOI: doi:10.1126/science.adn9560 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Methylated-dna--protein-cysteine methyltransferase,protein diaphanous homolog 1 (86 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Mdia1-bound f-actin barbed end. (Complex)
- Actin, cytoplasmic 1, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Actin filament (Complex from Homo sapiens)
- Mouse mdia1 (fh1fh2c domain) (Complex from Mus musculus)
Structure of the formin INF2 bound to the barbed end of F-actin.
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8rv2
Q-score: 0.43
Oosterheert W, Boiero Sanders M, Funk J, Prumbaum D, Raunser S, Bieling P
Science (2024) 384 pp. eadn9560-eadn9560 [ Pubmed: 38603491 DOI: doi:10.1126/science.adn9560 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Actin, alpha skeletal muscle (41 kDa, Protein from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Inf2 dimer (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Complex of the formin inf2 dimer that binds to the actin subunits at the barbed end of actin filaments. (Complex)
- Actin filament barbed end (Complex from Oryctolagus cuniculus)
- Isoform 2 of inverted formin-2 (84 kDa, Protein from Homo sapiens)