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Cryo-EM structure of human oligosaccharyltransferase complex OST-A
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6s7o
Q-score: 0.485
Ramirez AS, Kowal J, Locher KP
Science (2019) 366 pp. 1372-1375 [ Pubmed: 31831667 DOI: doi:10.1126/science.aaz3505 ]
- Oligosaccharyltransferase complex subunit ostc (Complex from Homo sapiens)
- (2~{s},3~{r},4~{r},5~{s},6~{s})-2-(hydroxymethyl)-6-[(1~{s},2~{r},3~{r},4~{r},5'~{s},6~{s},7~{r},8~{s},9~{r},12~{r},13~{r},15~{s},16~{s},18~{r})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol (610 Da, Ligand)
- Human oligosaccharyltransferase complex ost-a (Complex)
- Transmembrane protein 258 (9 kDa, Protein from Human)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (69 kDa, Protein from Human)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 (4 kDa, Protein from Human)
- Human oligosaccharyltransferase complex (Complex from Homo sapiens)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3a (80 kDa, Protein from Human)
- Oligosaccharyltransferase complex subunit ostc (16 kDa, Protein from Homo sapiens)
- (4r,7r)-4-hydroxy-n,n,n-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium (636 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- [(3~{r},6~{z},10~{z},14~{z},18~{z})-3,7,11,15,19,23-hexamethyltetracosa-6,10,14,18,22-pentaenyl] dihydrogen phosphate (508 Da, Ligand)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (68 kDa, Protein from Human)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit (50 kDa, Protein from Human)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1 (12 kDa, Protein from Human)
Cryo-EM structure of human oligosaccharyltransferase complex OST-B
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6s7t
Q-score: 0.509
Ramirez AS, Kowal J, Locher KP
Science (2019) 366 pp. 1372-1375 [ Pubmed: 31831667 DOI: doi:10.1126/science.aaz3505 ]
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3b (93 kDa, Protein from Human)
- (2~{s},3~{r},4~{r},5~{s},6~{s})-2-(hydroxymethyl)-6-[(1~{s},2~{r},3~{r},4~{r},5'~{s},6~{s},7~{r},8~{s},9~{r},12~{r},13~{r},15~{s},16~{s},18~{r})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol (610 Da, Ligand)
- Peptide (588 Da, Protein from Human)
- Magnesium transporter protein 1 (38 kDa, Protein from Homo sapiens)
- Human oligosaccharyltransferase complex ost-b (Complex)
- Magnesium transporter protein 1 (Complex from Homo sapiens)
- Transmembrane protein 258 (9 kDa, Protein from Human)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (69 kDa, Protein from Human)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 (4 kDa, Protein from Human)
- Human oligosaccharyltransferase complex (Complex from Homo sapiens)
- Malectin (32 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- (4r,7r)-4-hydroxy-n,n,n-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium (636 Da, Ligand)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (68 kDa, Protein from Human)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit (50 kDa, Protein from Human)
- (2z,6z,10z,14z,18z,22z,26z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl dihydrogen phosphate (642 Da, Ligand)
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1 (12 kDa, Protein from Human)
Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6um6
Q-score: 0.318
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ DOI: doi:10.1126/science.aay7199 Pubmed: 31806786 ]
- Dh270.6 light chain (22 kDa, Protein from Homo sapiens)
- Complex of antibody dh270.6 with hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh270.6 heavy chain (25 kDa, Protein from Homo sapiens)
- Ch848 10.17dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17dt gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 6peq
Q-score: 0.462
Science (2019) 366 pp. 1259-1263 [ DOI: doi:10.1126/science.aay2783 Pubmed: 31806817 ]
- Palmitoleic acid (254 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Glua2 in complex with cnih3 at 4:4 stoichiometry (470 kDa, Complex)
- Glutamate receptor 2 (Complex from Rattus norvegicus)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Protein cornichon homolog 3 (Complex from Mus musculus)
- Protein cornichon homolog 3 (20 kDa, Protein from Mus musculus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 6u5s
Q-score: 0.499
Science (2019) 366 pp. 1259-1263 [ DOI: doi:10.1126/science.aay2783 Pubmed: 31806817 ]
- Ntd of glua2 in complex with cnih3 at 4:4 stoichiometry (470 kDa, Complex from Rattus norvegicus)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in asymmetric global conformation
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 6u6i
Q-score: 0.496
Science (2019) 366 pp. 1259-1263 [ DOI: doi:10.1126/science.aay2783 Pubmed: 31806817 ]
- Ntd of glua2 in complex with cnih3 at 4:4 stoichiometry (470 kDa, Complex from Rattus norvegicus)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 6ucb
Q-score: 0.459
Science (2019) 366 pp. 1259-1263 [ DOI: doi:10.1126/science.aay2783 Pubmed: 31806817 ]
- Palmitoleic acid (254 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Glua2 in complex with cnih3 at 4:4 stoichiometry (470 kDa, Complex)
- Glutamate receptor 2 (Complex from Rattus norvegicus)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Protein cornichon homolog 3 (Complex from Mus musculus)
- Protein cornichon homolog 3 (20 kDa, Protein from Mus musculus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6ud4
Q-score: 0.412
Science (2019) 366 pp. 1259-1263 [ DOI: doi:10.1126/science.aay2783 Pubmed: 31806817 ]
- Cholesterol (386 Da, Ligand)
- Glua2 in complex with cnih3 at 4:4 stoichiometry (470 kDa, Complex)
- Glutamate receptor 2 (Complex from Rattus norvegicus)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Protein cornichon homolog 3 (Complex from Mus musculus)
- Protein cornichon homolog 3 (20 kDa, Protein from Mus musculus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6ud8
Q-score: 0.436
Science (2019) 366 pp. 1259-1263 [ DOI: doi:10.1126/science.aay2783 Pubmed: 31806817 ]
- Cholesterol (386 Da, Ligand)
- Glua2 in complex with cnih3 at 4:4 stoichiometry (470 kDa, Complex)
- Glutamate receptor 2 (Complex from Rattus norvegicus)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Protein cornichon homolog 3 (Complex from Mus musculus)
- Protein cornichon homolog 3 (20 kDa, Protein from Mus musculus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
The ClassA RSC-Nucleosome Complex
Resolution: 7.13 Å
EM Method: Single-particle
Fitted PDBs: 6kw3
Q-score: 0.086
Ye Y, Wu H, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR, Gao N, Chen Z
Science (2019) 366 pp. 838-843 [ DOI: doi:10.1126/science.aay0033 Pubmed: 31672915 ]
- Chromatin structure-remodeling complex protein rsc30 (101 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex subunit rsc9 (65 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna 167 (51 kDa, DNA from Homo sapiens)
- Chromatin structure-remodeling complex subunit rsc7 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex subunit rsc2 (102 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Rsc (Complex from Saccharomyces cerevisiae S288c)
- Chromatin structure-remodeling complex protein rsc3 (101 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone h4 (13 kDa, Protein from Xenopus laevis)
- Histone h2a (14 kDa, Protein from Xenopus laevis)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Chromatin structure-remodeling complex protein rsc6 (54 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex subunit sfh1 (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- High temperature lethal protein 1 (9 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Nuclear protein sth1/nps1 (156 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- Chromatin structure-remodeling complex subunit rsc4 (72 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex protein rsc8 (63 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Regulator of ty1 transposition protein 102 (17 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Actin-related protein 7 (53 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex protein rsc58 (57 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna 167 (51 kDa, DNA from Homo sapiens)
- Actin-like protein arp9 (53 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))