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Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ DOI: doi:10.1126/science.adk0582 Pubmed: 38753770 ]
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ DOI: doi:10.1126/science.adk0582 Pubmed: 38753770 ]
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ DOI: doi:10.1126/science.adk0582 Pubmed: 38753770 ]
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 pp. eadk0582-eadk0582 [ DOI: doi:10.1126/science.adk0582 Pubmed: 38753770 ]
HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8f92
Q-score: 0.516
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates 3rd JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) 384 [ DOI: doi:10.1126/science.adk0582 Pubmed: 38753770 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 env bg505_md39_b11 sosip in complex with fabs b11_d77.7 and rm20a3 (Complex)
- Bg505_md39_b11 gp120 (54 kDa, Protein from Human immunodeficiency virus)
- Bg505_md39_b11 gp41 (18 kDa, Protein from Human immunodeficiency virus)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- B11_d77.7 fab kappa light chain (11 kDa, Protein from Mus musculus)
- B11_d77.7 fab heavy chain (14 kDa, Protein from Mus musculus)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
Negative stain EM map of BG505 SOSIP in complex with Rh4O9.8 monoclonal antibody (as Fab fragment)
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ Pubmed: 35044813 DOI: doi:10.1126/sciadv.abk2039 ]
BG505 SOSIP.v5.2 in complex with the polyclonal Fab pAbC-1 from animal Rh.4O9
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7mdt
Q-score: 0.481
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ Pubmed: 35044813 DOI: doi:10.1126/sciadv.abk2039 ]
- Surface protein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Rh4o9.8 monoclonal antibody heavy chain (12 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2 in complex with the polyclonal fab sample isolated from animal rh4o9. (Complex from Human immunodeficiency virus)
- Rh4o9.8 monoclonal antibody light chain (11 kDa, Protein from Macaca mulatta)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 SOSIP.v5.2(7S) in complex with the monoclonal antibodies Rh.33172 mAb.1 and RM19R
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7mep
Q-score: 0.486
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ Pubmed: 35044813 DOI: doi:10.1126/sciadv.abk2039 ]
- Monoclonal antibodies rh.33172 mab.1 and rm19r (Complex from Macaca mulatta)
- Rm19r mab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) (Complex from Human immunodeficiency virus)
- Rm19r mab light chain (11 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) in complex with the monoclonal antibodies rh.33172 mab.1 and rm19r (Complex)
- Rh.33172 mab.1 heavy chain (14 kDa, Protein from Macaca mulatta)
- Bg505 sosipv5.2(7s) - gp120 (74 kDa, Protein from Human immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rh.33172 mab.1 light chain (11 kDa, Protein from Macaca mulatta)