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EMD-33058

Single-particle
3.09 Å
EMD-33058
3D View Gallery
Deposition: 14/03/2022
Map released: 29/06/2022
Last modified: 29/06/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-33058
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7x8s summary report (pdf.gz) Map and 7x8s FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex

EMD-33058

Single-particle
3.09 Å
EMD-33058
3D View Gallery
Deposition: 14/03/2022
Map released: 29/06/2022
Last modified: 29/06/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, Bos taurus, Rattus norvegicus, synthetic construct
Sample: Cryo-EM structure of the human glucagon like peptide 1 receptor in complex with WB4-24 and G protein
Fitted models: 7x8s

Deposition Authors: Cong ZT, Zhou QT, Li Y, Chen LN, Zhang ZC, Liang AY, Liu Q , Wu XY, Dai AT, Xia T, Wu W, Zhang Y , Yang DH, Wang MW
Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.
Cong Z, Zhou Q , Li Y, Chen LN, Zhang ZC, Liang A, Liu Q , Wu X, Dai A, Xia T, Wu W, Zhang Y , Yang D , Wang MW
(2022) PNAS , 119 , e2200155119 - e2200155119
PUBMED: 35561211
DOI: doi:10.1073/pnas.2200155119
ISSN: 1091-6490
ASTM: PNASA6