Ligand clusters for UniProt code Q02127

Ligand clusters for Q02127: Dihydroorotate dehydrogenase (quinone), mitochondrial from Homo sapiens

		Top 6 (of 41) ligand clusters Cluster 1. 88 ligand types 245 ligands Cluster 2. 8 ligand types 73 ligands Cluster 3. 7 ligand types 54 ligands Cluster 4. 6 ligand types 19 ligands Cluster 5. 3 ligand types 5 ligands Cluster 6. 4 ligand types 39 ligands
Representative protein: 2prlA

Structures

PDB		Schematic diagram
2prlA
6m2bA
3kvmA
3kvkA
6oc0A
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Cluster 1 contains 88 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: ORO × 8 Orotic acid PDB codes: 1d3g(A), 1d3h(A), 2b0m(A), 2bxv(A), 2fpt(A), 2fpv(A), 2fpy(A), 2fqi(A).
		2. Ligand: FMN × 75 flavin mononucleotide Flavin mononucleotide PDB codes: 1d3g(A), 1d3h(A), 2b0m(A), 2bxv(A), 2fpt(A), 2fpv(A), 2fpy(A), 2fqi(A), 2prh(A), 2prl(A), 2prm(A), 2wv8(A), 3f1q(A), 3fj6(A), 3fjl(A), 3g0u(A), 3g0x(A), 3kvj(A), 3kvk(A), 3kvl(A), 3kvm(A), 3u2o(A), 3w7r(A), 3zws(A), 3zwt(A), 4igh(A), 4jgd(A), 4js3(A), 4jts(A), 4jtt(A), 4jtu(A), 4ls0(A), 4ls1(A), 4ls2(A), 4oqv(A), 4rk8(A), 4rka(A), 4rli(A), 4rr4(A), 4ylw(A), 4zl1(A), 4zmg(A), 5h2z(A), 5h73(A), 5hin(A), 5hqe(A), 5mut(A), 5mvc(A), 5mvd(A), 5zf4(A), 5zf7(A), 5zf8(A), 5zf9(A), 5zfa(A), 5zfb(A), 6cjf(A), 6cjg(A), 6et4(A), 6fmd(A), 6gk0(A), 6idj(A), 6j3b(A), 6j3c(A), 6jmd(A), 6jme(A), 6lp6(A), 6lp7(A), 6lp8(A), 6lzl(A), 6m2b(A), 6oc0(A), 6oc1(A), 6qu7(A), 6vnd(A), 7k2u(A).
		3. Ligand: A26 × 1 teriflunomide (2z)-2-Cyano-3-Hydroxy-N-[4-(Trifluoromethyl) phenyl]but-2-Enamide PDB code: 1d3h(A).
		4. Ligand: ACY × 1 acetic acid Acetic acid PDB code: 4js3(A).
		5. Ligand: CE9 × 1 polidocanol Dodecyl nona ethylene glycol ether PDB code: 5k9d(A).
		6. Ligand: 3FT × 1 2-({[3-Fluoro-3'-(Trifluoromethoxy)biphenyl-4- Yl]amino}carbonyl)cyclopent-1-Ene-1-Carboxylic acid PDB code: 2bxv(A).
		7. Ligand: ILB × 1 2-({[3,5-Difluoro-3'-(Trifluoromethoxy)biphenyl-4- Yl]amino}carbonyl)cyclopent-1-Ene-1- Carboxylic acid PDB code: 2fpt(A).
		8. Ligand: ILH × 1 2-({[2,3,5,6-Tetrafluoro-3'-(Trifluoromethoxy) biphenyl-4-Yl]amino}carbonyl)cyclopenta-1,3-Diene-1- Carboxylic acid PDB code: 2fqi(A).
		9. Ligand: ILC × 1 3-{[(3-Fluoro-3'-Methoxybiphenyl-4-Yl) amino]carbonyl}thiophene-2-Carboxylic acid PDB code: 2fpv(A).
		10. Ligand: ILF × 1 3-({[3,5-Difluoro-3'-(Trifluoromethoxy)biphenyl-4- Yl]amino}carbonyl)thiophene-2-Carboxylic acid PDB code: 2fpy(A).
		11. Ligand: BRE × 1 2-Biphenyl-4-Yl-6-Fluoro-3-Methyl-Quinoline-4- Carboxylic acid PDB code: 1d3g(A).
		12. Ligand: 201 × 1 3-Amido-5-Biphenyl-Benzoic acid PDB code: 2b0m(A).
		13. Ligand: ORO × 63 Orotic acid PDB codes: 2prh(A), 2prl(A), 2prm(A), 2wv8(A), 3f1q(A), 3fj6(A), 3fjl(A), 3g0u(A), 3g0x(A), 3u2o(A), 3w7r(A), 3zws(A), 3zwt(A), 4igh(A), 4jgd(A), 4js3(A), 4jts(A), 4jtt(A), 4jtu(A), 4ls0(A), 4ls1(A), 4ls2(A), 4oqv(A), 4rk8(A), 4rka(A), 4rli(A), 4rr4(A), 4ylw(A), 4zl1(A), 4zmg(A), 5h2z(A), 5h73(A), 5hin(A), 5hqe(A), 5k9c(A), 5k9d(A), 5mut(A), 5mvc(A), 5mvd(A), 5zf4(A), 5zf7(A), 5zf8(A), 5zf9(A), 5zfa(A), 5zfb(A), 6cjf(A), 6cjg(A), 6fmd(A), 6idj(A), 6j3b(A), 6j3c(A), 6jmd(A), 6jme(A), 6lp6(A), 6lp7(A), 6lp8(A), 6lzl(A), 6m2b(A), 6oc0(A), 6oc1(A), 6qu7(A), 6vnd(A), 7k2u(A).
		14. Ligand: DDQ × 8 Decylamine-N,N-Dimethyl-N-Oxide PDB codes: 1d3g(A), 2prh(A), 2prl(A), 2wv8(A), 3w7r(A), 6et4(A), 6vnd(A).
		15. Ligand: DOR × 6 (4s)-2,6-Dioxohexahydropyrimidine-4-Carboxylic acid PDB codes: 3kvj(A), 3kvk(A), 3kvl(A), 3kvm(A), 6et4(A), 6gk0(A).
		16. Ligand: FNR × 2 1-Deoxy-1-(7,8-Dimethyl-2,4-Dioxo-3,4-Dihydro-2h- Benzo[g]pteridin-1-Id-10(5h)-Yl)-5-O-Phosphonato- D- Ribitol PDB codes: 5k9c(A), 5k9d(A).
		17. Ligand: ZWI × 2 3-[Decyl(dimethyl)ammonio]propane-1-Sulfonate PDB codes: 6cjf(A), 6cjg(A).
		18. Ligand: 03U × 1 Methyl 4-{[(2z)-2-Cyano-3-Hydroxypent-2-Enoyl]amino}- 4'-Fluorobiphenyl-2-Carboxylate PDB code: 3u2o(A).
		19. Ligand: 18X × 1 Methyl (2z)-Cyano[3-(3-Fluorobiphenyl-4-Yl)-4-Oxo-1,3- Thiazolidin-2-Ylidene]acetate PDB code: 4zl1(A).
		20. Ligand: 1EA × 1 6-Fluoro-2-[2-Methyl-4-Phenoxy-5-(Propan-2-Yl) phenyl]quinoline-4-Carboxylic acid PDB code: 4igh(A).
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Cluster 2 contains 8 ligand types

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Ligand		Description
		1. Ligand: GOL × 6 glycerin Glycerol PDB codes: 3w7r(A), 4igh(A), 6et4(A), 7k2u(A).
		2. Ligand: ACY × 3 acetic acid Acetic acid PDB codes: 6et4(A), 6gk0(A).
		3. Ligand: SO4 × 29 Sulfate ion PDB codes: 2fpv(A), 2fpy(A), 3w7r(A), 3zws(A), 3zwt(A), 4jgd(A), 4js3(A), 4jts(A), 4jtt(A), 4jtu(A), 4ls0(A), 4ls2(A), 4rk8(A), 4rka(A), 4ylw(A), 4zl1(A), 5h2z(A), 5hin(A), 5hqe(A), 5zf4(A), 5zfb(A), 6j3b(A), 6oc0(A), 7k2u(A),
		4. Ligand: ACT × 24 Acetate ion PDB codes: 2prl(A), 3u2o(A), 3w7r(A), 4ls1(A), 5h2z(A), 5h73(A), 5hqe(A), 5k9c(A), 5k9d(A), 5zf4(A), 5zf8(A), 5zf9(A), 5zfa(A), 6idj(A), 6j3b(A), 6jmd(A), 6jme(A), 6lp6(A), 6lp7(A), 6lp8(A), 6qu7(A).
		5. Ligand: DET × 7 Undecylamine-N,N-Dimethyl-N-Oxide PDB codes: 3kvj(A), 3kvk(A), 3kvl(A), 3kvm(A), 4jgd(A), 4jtu(A), 6vnd(A).
		6. Ligand: PGE × 2 Triethylene glycol PDB codes: 6fmd(A),
		7. Ligand: DDQ × 1 Decylamine-N,N-Dimethyl-N-Oxide PDB code: 6gk0(A).
		8. Ligand: PO4 × 1 Phosphate ion PDB code: 6oc1(A).

Cluster 3 contains 7 ligand types

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Ligand		Description
		1. Ligand: ACY × 6 acetic acid Acetic acid PDB codes: 3f1q(A), 3fjl(A), 4js3(A), 4oqv(A), 6et4(A), 6gk0(A).
		2. Ligand: GOL × 5 glycerin Glycerol PDB codes: 3w7r(A), 6vnd(A), 7k2u(A).
		3. Ligand: ACT × 33 Acetate ion PDB codes: 2fpv(A), 2fqi(A), 3fj6(A), 3w7r(A), 3zws(A), 3zwt(A), 4jts(A), 4jtt(A), 4ls1(A), 5h73(A), 5k9c(A), 5k9d(A), 5mut(A), 5mvc(A), 5mvd(A), 5zf4(A), 5zf7(A), 5zf8(A), 5zf9(A), 6fmd(A), 6idj(A), 6j3b(A), 6jmd(A), 6jme(A), 6lp6(A), 6lp7(A), 6lp8(A), 6qu7(A), 6vnd(A), 7k2u(A).
		4. Ligand: SO4 × 7 Sulfate ion PDB codes: 2fpt(A), 3w7r(A), 4ls0(A), 4rk8(A), 4ylw(A), 6j3b(A), 6j3c(A).
		5. Ligand: PGE × 1 Triethylene glycol PDB code: 6fmd(A).
		6. Ligand: ZWI × 1 3-[Decyl(dimethyl)ammonio]propane-1-Sulfonate PDB code: 4igh(A).
_Na		7. Metal: _NA × 1 PDB code: 4oqv(A).

Cluster 4 contains 6 ligand types

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Ligand		Description
		1. Ligand: ACY × 1 acetic acid Acetic acid PDB code: 3f1q(A).
		2. Ligand: GOL × 1 glycerin Glycerol PDB code: 4igh(A).
		3. Ligand: LDA × 7 Lauryl dimethylamine-N-Oxide PDB codes: 6j3b(A), 6j3c(A), 6jmd(A), 6jme(A), 6lp6(A), 6lp7(A), 6lp8(A).
		4. Ligand: SO4 × 5 Sulfate ion PDB codes: 4jgd(A), 4ls0(A), 4ls2(A), 4rk8(A), 4ylw(A).
		5. Ligand: ACT × 4 Acetate ion PDB codes: 3fj6(A), 6fmd(A), 6qu7(A), 7k2u(A).
		6. Ligand: DET × 1 Undecylamine-N,N-Dimethyl-N-Oxide PDB code: 6vnd(A).

Cluster 5 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 6vnd(A).
		2. Ligand: DDQ × 3 Decylamine-N,N-Dimethyl-N-Oxide PDB codes: 3w7r(A),
		3. Ligand: ACT × 1 Acetate ion PDB code: 6fmd(A).

Cluster 6 contains 4 ligand types

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Ligand		Description
		1. Ligand: ACY × 5 acetic acid Acetic acid PDB codes: 3fjl(A), 4js3(A), 4oqv(A), 6et4(A), 6gk0(A).
		2. Ligand: GOL × 2 glycerin Glycerol PDB codes: 3w7r(A), 6cjg(A).
		3. Ligand: ACT × 30 Acetate ion PDB codes: 1d3g(A), 1d3h(A), 2bxv(A), 2fpt(A), 2fpv(A), 2fpy(A), 2fqi(A), 2prl(A), 2wv8(A), 3kvj(A), 3kvl(A), 3kvm(A), 3u2o(A), 3zws(A), 3zwt(A), 4jtt(A), 4ls1(A), 4zmg(A), 5h73(A), 5k9c(A), 5k9d(A), 5mut(A), 5mvc(A), 5mvd(A), 5zf4(A), 5zf7(A), 5zf8(A), 5zf9(A), 5zfa(A), 6idj(A).
		4. Ligand: SO4 × 2 Sulfate ion PDB codes: 4jtu(A), 5zfb(A).