PDBsum entry 4zmg

Oxidoreductase/oxidoreductase inhibitor

PDB id: 4zmg

Contents

Protein chain

365 a.a.

Ligands

FMN

ORO

4R5

SO4 ×2

ACT

Waters ×144

PDB id:

4zmg

Name:

Oxidoreductase/oxidoreductase inhibitor

Title:

Crystal structure of human dihydroorotate dehydrogenase (dhodh) with dh03a338

Structure:

Dihydroorotate dehydrogenase (quinone), mitochondrial. Chain: a. Synonym: dhodehase,dihydroorotate oxidase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dhodh. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768.

Resolution:

1.90Å R-factor: 0.178 R-free: 0.198

Authors:

X.L.Ren,J.S.Zhu,L.L.Zhu,H.L.Li

Key ref:

X.L.Ren et al. Crystal structure of human dihydroorotate dehydrogena (dhodh) with dh03a338. To be published, .

Date:

04-May-15 Release date: 04-May-16

Protein chain

Q02127  (PYRD_HUMAN) -  Dihydroorotate dehydrogenase (quinone), mitochondrial from Homo sapiens

Seq: 395 a.a.

Struc: 365 a.a.

Enzyme reactions

• Enzyme class: E.C.1.3.5.2 - dihydroorotate dehydrogenase (quinone).
• Reaction: (S)-dihydroorotate + a quinone = orotate + a quinol

(S)-dihydroorotate (Bound ligand (Het Group name = ORO) corresponds exactly) + quinone = orotate + quinol

• Cofactor: FMN

FMN (Bound ligand (Het Group name = FMN) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site