PDBsum entry 4ls2

Oxidoreductase/oxidoreductase inhibitor

PDB id: 4ls2

Contents

Protein chain

364 a.a.

Ligands

FMN

ORO

SO4 ×5

ACT

3XS

Waters ×178

PDB id:

4ls2

Name:

Oxidoreductase/oxidoreductase inhibitor

Title:

Crystal structure of human dihydroorotate dehydrogenase (dhodh) with dh03a313

Structure:

Dihydroorotate dehydrogenase (quinone), mitochondrial. Chain: a. Fragment: unp residues 29-395. Synonym: dhodehase, dihydroorotate oxidase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dhodh. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.27Å R-factor: 0.153 R-free: 0.190

Authors:

L.Zhu,H.Li,X.Ren,J.Zhu

Key ref:

L.Zhu et al. Crystal structure of human dihydroorotate dehydrogena (dhodh) with dh03a313. To be published, .

Date:

21-Jul-13 Release date: 23-Jul-14

Protein chain

Q02127  (PYRD_HUMAN) -  Dihydroorotate dehydrogenase (quinone), mitochondrial from Homo sapiens

Seq: 395 a.a.

Struc: 364 a.a.

Enzyme reactions

• Enzyme class: E.C.1.3.5.2 - dihydroorotate dehydrogenase (quinone).
• Reaction: (S)-dihydroorotate + a quinone = orotate + a quinol

(S)-dihydroorotate (Bound ligand (Het Group name = ORO) corresponds exactly) + quinone = orotate + quinol

• Cofactor: FMN

FMN (Bound ligand (Het Group name = FMN) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site