wwPDB Hybrid/Integrative Methods Task Force recommendations published

wwPDB Hybrid/Integrative Methods Task Force recommendations published

In October 2014, PDBe hosted the first workshop of the wwPDB Hybrid/Integrative Methods Task Force at EMBL-EBI (see http://www.nature.com/news/data-bank-struggles-as-protein-imaging-ups-its-game-1.16196 and http://www.wwpdb.org/task/hybrid). The initial recommendations of this task force have now been published in a white paper.

   http://www.cell.com/structure/abstract/S0969-2126%2815%2900194-X

The main recommendations are:

- In addition to archiving the models themselves, all relevant experimental data and metadata as well as experimental and computational protocols should be archived; inclusivity is key.
- A flexible model representation needs to be developed, allowing for multi-scale models, multi-state models, ensembles of models, and models related by time or other order.
- Procedures for estimating the uncertainty of integrative models should be developed, validated, and adopted.
- A federated system of model and data archives should be created.
- Publication standards for integrative models should be established.

It is now up to the international community (including researchers, archives, journals and funders) to implement these recommendations.