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N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2.

Source organisms:
Biochemical function: protein binding
Biological process: iron-sulfur cluster assembly
Cellular component: cytosol

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EC 2.8.1.7: Cysteine desulfurase

Reaction catalysed:
(1a) L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
Systematic name:
L-cysteine:acceptor sulfurtransferase
Alternative Name(s):
  • Cysteine desulfurylase
  • IscS
  • NIFS
  • NifS
  • SufS

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01592
Domain description: NifU-like N terminal domain
Occurring in:
  1. Iron-sulfur cluster assembly enzyme ISCU
The deposited structure of PDB entry 6wih contains 1 copy of Pfam domain PF01592 (NifU-like N terminal domain) in Iron-sulfur cluster assembly enzyme ISCU. Showing 1 copy in chain D.

PF00550
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Acyl carrier protein
The deposited structure of PDB entry 6wih contains 1 copy of Pfam domain PF00550 (Phosphopantetheine attachment site) in Acyl carrier protein. Showing 1 copy in chain C.

PF05347
Domain description: Complex 1 protein (LYR family)
Occurring in:
  1. LYR motif-containing protein 4
The deposited structure of PDB entry 6wih contains 1 copy of Pfam domain PF05347 (Complex 1 protein (LYR family)) in LYR motif-containing protein 4. Showing 1 copy in chain B.

PF00266
Domain description: Aminotransferase class-V
Occurring in:
  1. Cysteine desulfurase
The deposited structure of PDB entry 6wih contains 1 copy of Pfam domain PF00266 (Aminotransferase class-V) in Cysteine desulfurase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002871
Domain description: NIF system FeS cluster assembly, NifU, N-terminal
Occurring in:
  1. Iron-sulfur cluster assembly enzyme ISCU
IPR036736
Domain description: ACP-like superfamily
Occurring in:
  1. Acyl carrier protein
IPR009081
Domain description: Phosphopantetheine binding ACP domain
Occurring in:
  1. Acyl carrier protein
IPR010240
Domain description: Cysteine desulfurase IscS
Occurring in:
  1. Cysteine desulfurase
IPR011339
Domain description: Iron-sulfur cluster assembly scaffold protein IscU
Occurring in:
  1. Iron-sulfur cluster assembly enzyme ISCU
IPR006162
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Acyl carrier protein
IPR003231
Domain description: Acyl carrier protein
Occurring in:
  1. Acyl carrier protein
IPR045297
Domain description: LYRM4, LYR domain
Occurring in:
  1. LYR motif-containing protein 4
IPR008011
Domain description: Complex 1 LYR protein domain
Occurring in:
  1. LYR motif-containing protein 4
IPR020578
Domain description: Aminotransferase class-V, pyridoxal-phosphate binding site
Occurring in:
  1. Cysteine desulfurase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Cysteine desulfurase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Cysteine desulfurase
IPR000192
Domain description: Aminotransferase class V domain
Occurring in:
  1. Cysteine desulfurase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Cysteine desulfurase
IPR016454
Domain description: Cysteine desulfurase
Occurring in:
  1. Cysteine desulfurase

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