Cysteine desulfurase (IPR016454)

Short name: Cysteine_dSase

Overlapping homologous superfamilies

Family relationships


This group represents a cysteine desulfurase, NifS type. NifS-like proteins are homodimeric and belong to the alpha-family of pyridoxal-5'-phoshate dependent enzymes [PMID: 10715213] which catalyse the reaction: L-cysteine + (enzyme)-cysteine = L-alanine + (enzyme)-S-sulphanylcysteine

Cysteine desulfurase proteins play a central role in the delivery of sulphur to a variety of metabolic pathways [PMID: 12860127]. It is involved in the biosynthesis of iron-sulphur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) [PMID: 12382038]. They are present in all organisms (except viruses). In eukaryotes these enzymes occur in mitochondria since this is the primary site for Fe-S cluster assembly [PMID: 12033984].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.