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Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead DNA sequence

X-ray diffraction
2.598Å resolution
PDB entry 6nce coloured by chain, front view.
PDB entry 6nce coloured by chain, side view.
PDB entry 6nce coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Forkhead box protein N3 and DNA
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Multimeric state: hetero trimer
Accessible surface area: 10180.81 Å2
Buried surface area: 3520.0 Å2
Dissociation area: 896.22 Å2
Dissociation energy (ΔGdiss): 11.05 kcal/mol
Dissociation entropy (TΔSdiss): 10.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-120330

Macromolecules

Forkhead box protein N3
Chain: A
Length: 100 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00409 (Residues: 112-210; Coverage: 20%)
Gene names: C14orf116, CHES1, FOXN3
Pfam: Forkhead domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Forkhead box protein N3 in PDB entry 6nce, assembly 1, front view.
Forkhead box protein N3 in PDB entry 6nce, assembly 1, side view.
Forkhead box protein N3 in PDB entry 6nce, assembly 1, top view.
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DNA chain C
Name: DNA (5'-D(*TP*CP*TP*TP*AP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3')
Representative chains: C
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 16 nucleotides
Theoretical weight: 4.91 KDa
DNA (5'-D(*TP*CP*TP*TP*AP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3') in PDB entry 6nce, assembly 1, front view.
DNA (5'-D(*TP*CP*TP*TP*AP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3') in PDB entry 6nce, assembly 1, side view.
DNA (5'-D(*TP*CP*TP*TP*AP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3') in PDB entry 6nce, assembly 1, top view.
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DNA chain D
Name: DNA (5'-D(*AP*CP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*TP*AP*AP*G)-3')
Representative chains: D
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 16 nucleotides
Theoretical weight: 4.89 KDa
DNA (5'-D(*AP*CP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*TP*AP*AP*G)-3') in PDB entry 6nce, assembly 1, front view.
DNA (5'-D(*AP*CP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*TP*AP*AP*G)-3') in PDB entry 6nce, assembly 1, side view.
DNA (5'-D(*AP*CP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*TP*AP*AP*G)-3') in PDB entry 6nce, assembly 1, top view.
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