Conserved Site

Fork head domain conserved site1 (IPR018122)

Short name: TF_fork_head_CS_1


This entry represents a conserved site found in the fork head domain, a conserved domain of about 100 amino-acid residues found in some eukaryotic transcription factors. The fork head domain is involved in DNA-binding [PMID: 8332212]. The signature in this entry corresponds to the N-terminal section of the fork head domain.

The fork head protein of Drosophila melanogaster, a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [PMID: 2566386]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [PMID: 2566386, PMID: 8332212, PMID: 1356269]. The fork head domain binds B-DNA as a monomer [PMID: 8332212], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [PMID: 1356269].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0043565 sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns