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A T cell receptor in complex with HLA-A0201 restricted Hepatitis C virus NS3 peptide (KLVALGINAV)

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: immune response
Cellular component: MHC class I protein complex

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EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.21.98: Hepacivirin

Reaction catalysed:
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
Alternative Name(s):
  • Cpro-2
  • Hepatitis C virus NS3 serine proteinase
  • NS3-4A serine proteinase complex

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
The deposited structure of PDB entry 5yxn contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 5yxn contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Beta-2-microglobulin. Showing 1 copy in chain D.

PF00129
Domain description: Class I Histocompatibility antigen, domains alpha 1 and 2
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 5yxn contains 1 copy of Pfam domain PF00129 (Class I Histocompatibility antigen, domains alpha 1 and 2) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. T cell receptor beta chain
  2. HLA class I histocompatibility antigen, A alpha chain
  3. Beta-2-microglobulin
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. T cell receptor alpha chain
  2. T cell receptor beta chain
  3. HLA class I histocompatibility antigen, A alpha chain
  4. Beta-2-microglobulin
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. T cell receptor alpha chain
  2. T cell receptor beta chain
  3. HLA class I histocompatibility antigen, A alpha chain
  4. Beta-2-microglobulin
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. T cell receptor alpha chain
  2. T cell receptor beta chain
  3. HLA class I histocompatibility antigen, A alpha chain
  4. Beta-2-microglobulin
IPR001039
Domain description: MHC class I alpha chain, alpha1 alpha2 domains
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. T cell receptor alpha chain
  2. T cell receptor beta chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. T cell receptor alpha chain
  2. T cell receptor beta chain
IPR015707
Domain description: Beta-2-Microglobulin
Occurring in:
  1. Beta-2-microglobulin
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR015370
Domain description: T-cell receptor alpha chain, constant domain
Occurring in:
  1. T cell receptor alpha chain
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR011161
Domain description: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. T cell receptor alpha chain
  2. T cell receptor beta chain
  3. HLA class I histocompatibility antigen, A alpha chain
  4. Beta-2-microglobulin
The deposited structure of PDB entry 5yxn contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in T cell receptor alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 5yxn contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T cell receptor beta chain. Showing 2 copies in chain B.
The deposited structure of PDB entry 5yxn contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 5yxn contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-2-microglobulin. Showing 1 copy in chain D.
3.30.500.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homology: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 5yxn contains 1 copy of CATH domain 3.30.500.10 (Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain C.

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