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Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF40431

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: membrane

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF15901
Domain description: Sortilin, neurotensin receptor 3, C-terminal
Occurring in:
  1. Sortilin
The deposited structure of PDB entry 4msl contains 1 copy of Pfam domain PF15901 (Sortilin, neurotensin receptor 3, C-terminal) in Sortilin. Showing 1 copy in chain A.

PF15902
Domain description: Sortilin, neurotensin receptor 3,
Occurring in:
  1. Sortilin
The deposited structure of PDB entry 4msl contains 1 copy of Pfam domain PF15902 (Sortilin, neurotensin receptor 3,) in Sortilin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Sortilin
IPR031777
Domain description: Sortilin, C-terminal
Occurring in:
  1. Sortilin
IPR031778
Domain description: Sortilin, N-terminal
Occurring in:
  1. Sortilin
IPR006581
Domain description: VPS10
Occurring in:
  1. Sortilin

Structure domains

CATH CATH domains
3.30.60.270
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Sortilin
The deposited structure of PDB entry 4msl contains 1 copy of CATH domain 3.30.60.270 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Sortilin. Showing 1 copy in chain A.
2.10.70.80
Class: Mainly Beta
Architecture: Ribbon
Topology: Complement Module; domain 1
Homology: Complement Module; domain 1
Occurring in:
  1. Sortilin
The deposited structure of PDB entry 4msl contains 1 copy of CATH domain 2.10.70.80 (Complement Module; domain 1) in Sortilin. Showing 1 copy in chain A.

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