Domain

Sortilin, C-terminal (IPR031777)

Short name: Sortilin_C

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins [PMID: 9013611, PMID: 9756851]. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules [PMID: 10085125, PMID: 11331584]. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarisation to modulate cell survival and synaptic plasticity [PMID: 19122660].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam