Sortilin, N-terminal (IPR031778)

Short name: Sortilin_N

Overlapping homologous superfamilies


Domain relationships



Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of the vacuolar protein sorting 10 protein domain (Vps10-D) receptor family that binds neurotrophic factors and neuropeptides [PMID: 25345507]. This entry represents a domain that constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage [PMID: 9013611, PMID: 9756851]. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it [PMID: 19122660]. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)-6 and brain-derived neurotrophic factor (BDNF)-7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1 [PMID: 19122660, PMID: 10085125].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.