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Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: cell surface receptor protein serine/threonine kinase signaling pathway
Cellular component: membrane

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EC 2.7.11.30: Receptor protein serine/threonine kinase

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Systematic name:
ATP:[receptor-protein] phosphotransferase
Alternative Name(s):
  • Activin receptor kinase
  • Receptor serine/threonine protein kinase
  • Receptor type I serine/threonine protein kinase
  • Receptor type II serine/threonine protein kinase
  • STK13
  • TGF-beta kinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01064
Domain description: Activin types I and II receptor domain
Occurring in:
  1. Activin receptor type-2B
The deposited structure of PDB entry 4fao contains 12 copies of Pfam domain PF01064 (Activin types I and II receptor domain) in Activin receptor type-2B. Showing 1 copy in chain E.

PF00019
Domain description: Transforming growth factor beta like domain
Occurring in:
  1. Growth/differentiation factor 2
The deposited structure of PDB entry 4fao contains 12 copies of Pfam domain PF00019 (Transforming growth factor beta like domain) in Growth/differentiation factor 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000333
Domain description: Ser/Thr protein kinase, TGFB receptor
Occurring in:
  1. Activin receptor type-2B
IPR045860
Domain description: Snake toxin-like superfamily
Occurring in:
  1. Activin receptor type-1-like
  2. Activin receptor type-2B
IPR001839
Domain description: Transforming growth factor-beta, C-terminal
Occurring in:
  1. Growth/differentiation factor 2
IPR029034
Domain description: Cystine-knot cytokine
Occurring in:
  1. Growth/differentiation factor 2
IPR000472
Domain description: Activin types I and II receptor domain
Occurring in:
  1. Activin receptor type-2B
IPR017948
Domain description: Transforming growth factor beta, conserved site
Occurring in:
  1. Growth/differentiation factor 2
IPR015615
Domain description: Transforming growth factor-beta-related
Occurring in:
  1. Growth/differentiation factor 2

Structure domains

CATH CATH domains
2.10.60.10
Class: Mainly Beta
Architecture: Ribbon
Topology: CD59
Homology: CD59
Occurring in:
  1. Activin receptor type-1-like
  2. Activin receptor type-2B
The deposited structure of PDB entry 4fao contains 12 copies of CATH domain 2.10.60.10 (CD59) in Serine/threonine-protein kinase receptor R3. Showing 1 copy in chain C.
The deposited structure of PDB entry 4fao contains 12 copies of CATH domain 2.10.60.10 (CD59) in Activin receptor type-2B. Showing 1 copy in chain E.
2.10.90.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Cystine Knot Cytokines, subunit B
Homology: Cystine-knot cytokines
Occurring in:
  1. Growth/differentiation factor 2
The deposited structure of PDB entry 4fao contains 12 copies of CATH domain 2.10.90.10 (Cystine Knot Cytokines, subunit B) in Growth/differentiation factor 2. Showing 1 copy in chain A.

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