Transforming growth factor-beta-related (IPR015615)

Short name: TGF-beta-rel

Overlapping homologous superfamilies


Family relationships


The transforming growth factor (TGF)-beta superfamily of cytokines is comprised of a number of structurally related, secreted polypeptides that regulate a multitude of cellular processes including proliferation, differentiation and neoplastic transformation [PMID: 15032667]. Family members include the activins/inhibins, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and TGF-betas [PMID: 15180456]. These growth regulatory molecules induce ligand-mediated hetero-oligomerisation of distinct type II and type I serine/threonine kinase receptors that transmit signals predominantly through receptor-activated Smad proteins but also induce Smad-independent pathways.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.