Ser/Thr protein kinase, TGFB receptor (IPR000333)

Short name: TGFB_receptor

Overlapping homologous superfamilies

Family relationships


Transforming growth factor-beta (TGF-beta) forms a family with other growth factors. The receptors for most of the members of this growth factor family are related. These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain [PMID: 9023056, PMID: 8047140, PMID: 8909794]. The C-terminal part of the extracellular domain is conserved. Some of the receptors of this family contain subclass-specific N-terminal extensions of this homology domain. The type I receptors also possess 7 extracellular residues preceding the cysteine box.

GO terms

Biological Process

GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway

Molecular Function

GO:0005524 ATP binding
GO:0004675 transmembrane receptor protein serine/threonine kinase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.