Conserved Site

Transforming growth factor beta, conserved site (IPR017948)

Short name: TGFb_CS

Description

Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein [PMID: 8679613].

A number of proteins are known to be related to TGF-beta-1 [PMID: 1575734, PMID: 8199356]. Proteins from the TGF-beta family are only active as homo- or heterodimer; the two chains being linked by a single disulphide bond. From X-ray studies of TGF-beta-2 [PMID: 1631557], it is known that all the other cysteines are involved in intrachain disulphide bonds. There are four disulphide bonds in the TGF-beta's and in inhibin beta chains, while the other members of this family lack the first bond.

The regulatory cytokine TGF-beta exerts tumour-suppressive effects, but also modulates cell invasion and immune regulation [PMID: 18662538]. Misregulation of the TGF-beta signalling pathway can result in tumour development.

This entry represents a conserved region within the TGF-beta domain that includes two of the conserved cysteines.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008083 growth factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns