Domain

TGF-beta receptor/activin receptor, type I/II (IPR000472)

Short name: Activin_rcpt

Domain relationships

None.

Description

Transforming growth factor-beta (TGF-beta) forms a family with other growth factors described in PDOC00223. The receptors for most of the members of this growth factor family are related. These proteins are receptor-type kinases of Ser/Thr type PDOC00100), which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain [PMID: 9023056, PMID: 8047140, PMID: 8909794]. The C-terminal part of the extracellular domain is conserved. Some of the receptors of this family contain subclass-specific N-terminal extensions of this homology domain. The type I receptors also possess 7 extracellular residues preceding the cysteine box.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005024 transforming growth factor beta-activated receptor activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam