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Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation

X-ray diffraction
2Å resolution
PDB entry 3mn6 coloured by chain, front view.
PDB entry 3mn6 coloured by chain, side view.
PDB entry 3mn6 coloured by chain, top view.
Source organism: Drosophila melanogaster
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Actin-5C and peptide
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Multimeric state: hetero dimer
Accessible surface area: 16865.21 Å2
Buried surface area: 2017.82 Å2
Dissociation area: 463.87 Å2
Dissociation energy (ΔGdiss): 1.63 kcal/mol
Dissociation entropy (TΔSdiss): 8.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145607
Assembly 2
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Assembly Name: Actin-5C and peptide
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Multimeric state: hetero dimer
Accessible surface area: 16893.13 Å2
Buried surface area: 1994.62 Å2
Dissociation area: 451.82 Å2
Dissociation energy (ΔGdiss): 1.36 kcal/mol
Dissociation entropy (TΔSdiss): 8.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145607
Assembly 3
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Assembly Name: Actin-5C and peptide
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Multimeric state: hetero dimer
Accessible surface area: 16919.59 Å2
Buried surface area: 2015.03 Å2
Dissociation area: 458.94 Å2
Dissociation energy (ΔGdiss): 1.72 kcal/mol
Dissociation entropy (TΔSdiss): 8.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145607

Macromolecules

Actin-5C
Chains: A, F, K
Length: 374 amino acids
Theoretical weight: 41.72 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10987 (Residues: 3-376; Coverage: 100%)
Gene names: Act5C, CG4027
Pfam: Actin
InterPro:
CATH:
Actin-5C in PDB entry 3mn6, assembly 1, front view.
Actin-5C in PDB entry 3mn6, assembly 1, side view.
Actin-5C in PDB entry 3mn6, assembly 1, top view.
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Protein spire
Chains: X, Y, Z
Length: 19 amino acids
Theoretical weight: 1.64 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
Protein spire in PDB entry 3mn6, assembly 1, front view.
Protein spire in PDB entry 3mn6, assembly 1, side view.
Protein spire in PDB entry 3mn6, assembly 1, top view.
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