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Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation

Source organism: Drosophila melanogaster
Biochemical function: hydrolase activity
Biological process: tube formation
Cellular component: brahma complex

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00022
Domain description: Actin
Occurring in:
  1. Actin-5C
The deposited structure of PDB entry 3mn6 contains 3 copies of Pfam domain PF00022 (Actin) in Actin-5C. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004000
Domain description: Actin family
Occurring in:
  1. Actin-5C
IPR004001
Domain description: Actin, conserved site
Occurring in:
  1. Actin-5C
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Actin-5C
IPR020902
Domain description: Actin/actin-like conserved site
Occurring in:
  1. Actin-5C

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Actin-5C
The deposited structure of PDB entry 3mn6 contains 6 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Actin-5C. Showing 2 copies in chain A.
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Actin-5C
The deposited structure of PDB entry 3mn6 contains 3 copies of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Actin-5C. Showing 1 copy in chain A.

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