Structure for lopinavir (A02.001 inhibitor)

Summary Structure Literature

 

TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
feline immunodeficiency virus retropepsin ( feline immunodeficiency virus)
complex with lopinavir 1.80 Å 3OGQ 3OGQ 3OGQ 3OGQ 3OGQ 3OGQ
HIV-1 retropepsin ( human immunodeficiency virus 1)
complex with lopinavir 2.80 Å 1MUI 1MUI 1MUI 1MUI 1MUI 1MUI Stoll et al., 2002
complex with lopinavir 1.95 Å 2Q5K 2Q5K 2Q5K 2Q5K 2Q5K 2Q5K Reddy et al., 2007
Ile47Ala mutant on reduced susceptibility to the protease inhibitor lopinavir 2.31 Å 2Z54 2Z54 2Z54 2Z54 2Z54 2Z54
wild-type; complex with lopinavir 1.26 Å 6DJ1 6DJ1 6DJ1 6DJ1 6DJ1 6DJ1
Leu76Val mutant; complex with lopinavir 1.36 Å 6DJ2 6DJ2 6DJ2 6DJ2 6DJ2 6DJ2