Structure for phosphoramidon (M04.001 inhibitor)

Summary Structure Literature

 

PDB Organism Resolution Comment
1DMT_A Homo sapiens 2.10 Å complex with phosphoramidon
The catalytic zinc is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His583 and His587 in purple and Glu646 in blue. The catalytic residues are shown in ball-and-stick representation: Glu584 in blue and Asp650 in pink. Carbohydrates are shown as CPK spheres in yellow.
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1TLP Bacillus thermoproteolyticus 2.30 Å complex with phosphoramidon
The catalytic zinc is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His374 and His378 in purple and Glu398 in blue. The catalytic Glu375 is shown in blue. Phosphoramidon is shown in grey.
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3DWB Homo sapiens 2.38 Å complex with phosphoramidon
The catalytic zinc atom is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His607 and His611 in purple, Glu667 in blue. The catalytic residues are shown in ball-and-stick representation: Glu608 in blue and Asp671 in pink. The bound inhibitor is shown in grey ball-and-stick representation.
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3ZUK Mycobacterium tuberculosis 2.60 Å complex with phosphoramidon
The catalytic zinc atom is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His387 and His391 in purple, Glu454 in blue. The catalytic residues are shown in ball-and-stick representation: Glu388 in blue and Asp458 in pink. The bound inhibitor is shown in grey ball-and-stick representation.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
thermolysin ( Bacillus thermoproteolyticus)
complex with phosphoramidon 2.30 Å 1TLP 1TLP 1TLP 1TLP 1TLP 1TLP Tronrud et al., 1986
neprilysin ( Homo sapiens)
complex with phosphoramidon 2.10 Å 1DMT 1DMT 1DMT 1DMT 1DMT 1DMT Oefner et al., 2000
endothelin-converting enzyme 1 ( Homo sapiens)
complex with phosphoramidon 2.38 Å 3DWB 3DWB 3DWB 3DWB 3DWB 3DWB Schulz et al., 2009
farnesylated-protein converting enzyme 1 ( Homo sapiens)
complex with phosphoramidon 3.85 Å 6BH8 6BH8 6BH8 6BH8 6BH8 6BH8
Zmp1 peptidase (Mycobacterium-type) ( Mycobacterium tuberculosis)
complex with phosphoramidon 2.60 Å 3ZUK 3ZUK 3ZUK 3ZUK 3ZUK 3ZUK Ferraris et al., 2011
neprilysin ( Oryctolagus cuniculus)
complex with phosphoramidon 2.80 Å 4ZR5 4ZR5 4ZR5 4ZR5 4ZR5 4ZR5
pseudolysin ( Pseudomonas aeruginosa)
complex with phosphoramidon 1.40 Å 3DBK 3DBK 3DBK 3DBK 3DBK 3DBK