Structure for E64 (C01.001 inhibitor)

PDB	Organism	Resolution	Comment
1AEC	Actinidia deliciosa	1.86 Å	complex with E64
Catalytic residues are shown in ball-and-stick representation: Cys151 in yellow, His288 in purple and Asn308 in pink. E-64 is shown in grey in ball-and-stick representation.

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1ATK	Homo sapiens	2.20 Å	complex with E64
Catalytic residues are shown in ball-and-stick representation: Cys133 in yellow, His276 in purple and Asn296 in pink. E-64 is shown in grey in ball-and-stick representation.

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1CV8	Staphylococcus aureus	1.75 Å	complex with E64
Catalytic residues are shown in ball-and-stick representation: Cys24 in yellow, His120 in purple and Asn141 in pink. E-64 is shown in grey in ball-and-stick representation.

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1MEG	Carica papaya	2.00 Å	Asp185Glu mutant; complex with E64
Catalytic residues are shown in ball-and-stick representation: Cys157 in yellow, His291 in purple and Asn311 in pink.

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3BCN	Tabernaemontana divaricata	2.85 Å	complex with E64
Catalytic residues are shown in ball-and-stick representation: Gln8 in light pink, Cys14 in yellow, His157 in purple and Asn173 in dark pink. The bound inhibitor E64 is shown in grey ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
actinidin ( Actinidia deliciosa)
complex with E64	1.86 Å	1AEC	1AEC	1AEC	1AEC	1AEC	1AEC	Varughese et al., 1992
ananain ( Ananas comosus)
complex with E-64	1.98 Å	6MIS	6MIS	6MIS	6MIS	6MIS	6MIS
caricain ( Carica papaya)
Asp185Glu mutant; complex with E64	2.00 Å	1MEG	1MEG	1MEG	1MEG	1MEG	1MEG	Katerelos et al., 1996
cathepsin K ( Homo sapiens)
complex with E64	2.20 Å	1ATK	1ATK	1ATK	1ATK	1ATK	1ATK	Zhao et al., 1997
calpain-3 ( Homo sapiens)
protease core; complex with E-64	2.80 Å	6BJD	6BJD	6BJD	6BJD	6BJD	6BJD
falcipain-2 ( Plasmodium falciparum)
complex with E64	2.90 Å	3BPF	3BPF	3BPF	3BPF	3BPF	3BPF	Kerr et al., 2009
family C100 unassigned peptidases ( Polyporus squamosus)
complex with E64	1.49 Å	5MUA	5MUA	5MUA	5MUA	5MUA	5MUA
calpain-1 ( Rattus norvegicus)
peptidase unit only; complex with E64	1.90 Å	1TLO	1TLO	1TLO	1TLO	1TLO	1TLO	Moldoveanu et al., 2004
staphopain A ( Staphylococcus aureus)
complex with E64	1.75 Å	1CV8	1CV8	1CV8	1CV8	1CV8	1CV8	Hofmann et al., 1993
sortase B ( Staphylococcus aureus)
complex with E-64	2.70 Å	1QX6	1QX6	1QX6	1QX6	1QX6	1QX6	Zong et al., 2004
ervatamin A ( Tabernaemontana divaricata)
ervatamin-C; complex with E64	2.70 Å	2PRE	2PRE	2PRE	2PRE	2PRE	2PRE	Ghosh et al., 2008
complex with E64	2.90 Å	2PSC	2PSC	2PSC	2PSC	2PSC	2PSC	Ghosh et al., 2008
complex with E64	2.85 Å	3BCN	3BCN	3BCN	3BCN	3BCN	3BCN	Ghosh et al., 2008