Structure for inhibitor I32.005: survivin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

PDB	Organism	Resolution	Comment
1E31	Homo sapiens	2.71 Å	dimer
One monomer of the dimer is shown. The structural zinc ion is shown as a light grey CPK sphere. The reactive site residue Asp71 is shown in ball-and-stick representation in pink

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
dimer	2.71 Å	1E31	1E31	1E31	1E31	1E31	1E31	Chantalat et al., 2000
mature inhibitor	2.58 Å	1F3H	1F3H	1F3H	1F3H	1F3H	1F3H	Verdecia et al., 2000
NMR structure	0.00 Å	1XOX	1XOX	1XOX	1XOX	1XOX	1XOX	Sun et al., 2005
complex with borealin-incenp core	1.40 Å	2QFA	2QFA	2QFA	2QFA	2QFA	2QFA	Jeyaprakash et al., 2007
complex with borealin	2.40 Å	2RAW	2RAW	2RAW	2RAW	2RAW	2RAW	Bourhis et al., 2007
complex with borealin (20-78)	3.30 Å	2RAX	2RAX	2RAX	2RAX	2RAX	2RAX	Bourhis et al., 2007
crystal structure of human survivin bound to histone h3 phosphorylatedon threonine-3.	2.18 Å	3UEC	3UEC	3UEC	3UEC	3UEC	3UEC
bound to histone h3 phosphorylatedon threonine-3 (c2 space group).	2.70 Å	3UED	3UED	3UED	3UED	3UED	3UED
crystal structure of human survivin k62a mutant bound to n-terminal histone h3	2.61 Å	3UEE	3UEE	3UEE	3UEE	3UEE	3UEE
crystal structure of human survivin bound to histone h3 (c2 space group).	2.45 Å	3UEF	3UEF	3UEF	3UEF	3UEF	3UEF
crystal structure of human survivin k62a mutant	2.80 Å	3UEG	3UEG	3UEG	3UEG	3UEG	3UEG
crystal structure of human survivin h80a mutant	2.60 Å	3UEH	3UEH	3UEH	3UEH	3UEH	3UEH
crystal structure of human survivin e65a mutant	2.70 Å	3UEI	3UEI	3UEI	3UEI	3UEI	3UEI
complex with t3 phosphorylated h3(1-15) peptide	2.40 Å	3UIG	3UIG	3UIG	3UIG	3UIG	3UIG
complex with smac/diablo(1-15) peptide	2.40 Å	3UIH	3UIH	3UIH	3UIH	3UIH	3UIH
complex with h3(1-10) peptide	2.60 Å	3UII	3UII	3UII	3UII	3UII	3UII
Lys62Tyr/His80Trp mutant; complex with smac/diablo(1-15) peptide	2.71 Å	3UIJ	3UIJ	3UIJ	3UIJ	3UIJ	3UIJ
Lys62Tyr/His80Trp mutant; complex with h3(1-10) peptide	2.70 Å	3UIK	3UIK	3UIK	3UIK	3UIK	3UIK
crystal structure of survivin bound to the n-terminal tail of hsgo1	2.60 Å	4A0I	4A0I	4A0I	4A0I	4A0I	4A0I
crystal structure of survivin bound to the phosphorylated n- terminal tail of histone h3	2.80 Å	4A0J	4A0J	4A0J	4A0J	4A0J	4A0J
crystal structure of survivin bound to the phosphorylated n- terminal tail of histone h3	2.74 Å	4A0N	4A0N	4A0N	4A0N	4A0N	4A0N
Mus musculus
mature inhibitor	2.80 Å	1M4M	1M4M	1M4M	1M4M	1M4M	1M4M	Muchmore et al., 2000