Structure for inhibitor I04.001: alpha-1-peptidase inhibitor

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

PDB	Organism	Resolution	Comment
1QLP	Homo sapiens	2.00 Å	uncleaved
The reactive site residue Met382 is shown in ball-and-stick representation in green.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
uncleaved	2.70 Å	1ATU	1ATU	1ATU	1ATU	1ATU	1ATU	Ryu et al., 1996
cleaved antitrypsin polymer	3.00 Å	1D5S	1D5S	1D5S	1D5S	1D5S	1D5S	Dunstone et al., 2000
uncleaved form	2.10 Å	1HP7	1HP7	1HP7	1HP7	1HP7	1HP7	Kim et al., 2001
engineered form	2.20 Å	1IZ2	1IZ2	1IZ2	1IZ2	1IZ2	1IZ2	Im et al., 2002
uncleaved	3.46 Å	1KCT	1KCT	1KCT	1KCT	1KCT	1KCT	Song et al., 1995
native A1PI-Pittsburgh	2.65 Å	1OO8	1OO8	1OO8	1OO8	1OO8	1OO8	Dementiev et al., 2003
non-covalent complex between alpha-1-pi-pittsburgh and s195a trypsin	2.30 Å	1OPH	1OPH	1OPH	1OPH	1OPH	1OPH	Dementiev et al., 2003
Phe51Leu mutant	2.90 Å	1PSI	1PSI	1PSI	1PSI	1PSI	1PSI	Elliott et al., 1996
uncleaved	2.00 Å	1QLP	1QLP	1QLP	1QLP	1QLP	1QLP	Elliott et al., 1998
cleaved alpha-1-antitrypsin polymer	2.60 Å	1QMB	1QMB	1QMB	1QMB	1QMB	1QMB	Huntington et al., 1999
complex with pig elastase-1	3.30 Å	2D26	2D26	2D26	2D26	2D26	2D26	Dementiev et al., 2006
crystal form a	2.00 Å	2QUG	2QUG	2QUG	2QUG	2QUG	2QUG	Pearce et al., 2008
crystal form b	2.44 Å	3CWL	3CWL	3CWL	3CWL	3CWL	3CWL	Pearce et al., 2008
complex with citrate	2.51 Å	3CWM	3CWM	3CWM	3CWM	3CWM	3CWM	Pearce et al., 2008
Tthr114Phe mutant	2.20 Å	3DRM	3DRM	3DRM	3DRM	3DRM	3DRM	Gooptu et al., 2009
Gly117Phe mutant	3.20 Å	3DRU	3DRU	3DRU	3DRU	3DRU	3DRU	Gooptu et al., 2009
cleaved antitrypsin with P10 Pro, and P9-p6 Asp	1.50 Å	3NDD	3NDD	3NDD	3NDD	3NDD	3NDD
cleaved antitrypsin with P8-P6 Asp	2.70 Å	3NDF	3NDF	3NDF	3NDF	3NDF	3NDF
intact native wild-type	1.81 Å	3NE4	3NE4	3NE4	3NE4	3NE4	3NE4
crystal structure of an alpha-1-antitrypsin trimer	3.90 Å	3T1P	3T1P	3T1P	3T1P	3T1P	3T1P
a1at:ttai ternary complex	1.91 Å	4PYW	4PYW	4PYW	4PYW	4PYW	4PYW
crystal structure of recombinant human z alpha-1-antitrypsin	3.34 Å	5IO1	5IO1	5IO1	5IO1	5IO1	5IO1
crystal structure of native alpha-1-antitrypsin with seven stabilisingmutations	1.67 Å	5NBU	5NBU	5NBU	5NBU	5NBU	5NBU
crystal structure of native alpha-1-antitrypsin with seven stabilisingmutations	1.73 Å	5NBV	5NBV	5NBV	5NBV	5NBV	5NBV
cleaved	3.00 Å	7API	7API	7API	7API	7API	7API	Engh et al., 1989
cleaved	3.10 Å	8API	8API	8API	8API	8API	8API	Engh et al., 1989
cleaved	3.00 Å	9API	9API	9API	9API	9API	9API	Engh et al., 1989