Small-molecule inhibitor: gabexate mesilate
Name
- Common name
- gabexate mesilate
- Other names
- FOY; FOY007
Inhibition
- History
- Gabexate mesilate was described in 1978 by workers at the ONO Pharmaceutical Company, Osaka.
- Peptidases inhibited
- A variety of 'trypsin-like' peptidases in family S1 are inhibited. Human tryptase (Ki = 95 nM: Mori et al., 2003).
- Mechanism
- Inhibition is reversible.
- Pharmaceutical relevance
- Gabexate mesilate has been used clinically as a drug, particularly for pancreatitis, coagulation disorders and allergic conditions.
Chemistry
- CID at PubChem
- 182710
- Structure
![[gabexate mesilate (S01.151 inhibitor) structure ]](/merops/smi/structures/gabexate.gif)
- Chemical/biochemical name
- Ethyl p-hydroxybenzoate 6-guanidinohexanoate
- Formula weight
- 373
