Small-molecule inhibitor: ovalicin

Summary Structure Literature

Name

Common name: ovalicin

Inhibition

Peptidases inhibited: methionyl aminopeptidase 2
Mechanism: See fumagillin.
Pharmaceutical relevance: Activities described include immunosuppression (Lazary & Stahelin, 1969), inhibition of endothelial cell proliferation and thus of angiogenesis (Griffith et al., 1997), and therapy for microsporidiosis (Didier et al., 2006).

Chemistry

CID at PubChem: 5289086
Structure
Chemical/biochemical name: (2S,3R,4R)-3,4-dihydroxy-2-methoxy-4-methyl-3-[(2S,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]cyclohexan-1-one
Related inhibitors: Ovalicin is an epoxide-containing natural product related to fumagillin and TNP-470 as is described more fully under fumagillin.