Small-molecule inhibitor: AK295

Summary Literature

Name

Common name: AK295
Other names: calpain inhibitor XI; CX295

Inhibition

Peptidases inhibited: Compound AK295 was developed (Bartus et al., 1994) from a series of peptide alpha-ketoamide inhibitors described by Li et al.. (1993). It has K_i 27 - 42 nM for calpain 1 and calpain 2, but much weaker inhibition of cathepsin B (Saatman et al., 1996).
Mechanism: Inhibition is reversible.

Chemistry

CID at PubChem: 183798
Structure
Chemical/biochemical name: Z-Leu-aminobutyric acid-CONH(CH2)3-morpholine
Formula weight: 505