Small-molecule inhibitor: Ro 28-2653

Name

Peptidases inhibited: Inhibition is high selectivity for matrix metallopeptidase-2, matrix metallopeptidase-9 and membrane-type matrix metallopeptidase-1 (Maquoi et al., 2004). Does not inhibit meprin A complex peptidase (Kruse et al., 2004).
Mechanism: Inhibition is reversible.
Pharmaceutical relevance: This compound is a selective and orally bioavailable matrix metallopeptidase inhibitor that has therapeutic potential for conditions including cancer (see Literature).

CID at PubChem: 9832179
Structure
Chemical/biochemical name: 5-biphenyl-4-yl-5-[4-(4-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione
Formula weight: 485