Small-molecule inhibitor: ZJ-43

Summary Literature

Name

Common name: ZJ-43
Other names: PGI-02776 (prodrug of ZJ-43)

Inhibition

History: ZJ-43 is one of a series of glutamate analogues that are inhibitors of glutamate carboxypeptidase II. Being highly polar, the molecule does not readily cross the blood-brain barrier, but a di-ester prodrug form showed neuroprotective activity (Feng et al., 2012).
Peptidases inhibited: glutamate carboxypeptidase II
Pharmaceutical relevance: Analgesic and other activities have been reported (e.g. Yamamoto et al. (2008)). .

Chemistry

Structure