Literature for GW-311616 (S01.131 inhibitor)

(Topics flags: S Structure, T Target, I Inhibitor, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

2018
1. Wen,G., An,W., Chen,J., Maguire,E.M., Chen,Q., Yang,F., Pearce,S.W.A., Kyriakides,M., Zhang,L., Ye,S., Nourshargh,S. and Xiao,Q.
   Genetic and pharmacologic inhibition of the neutrophil elastase inhibits experimental atherosclerosis
   J Am Heart Assoc7, PubMed  Europe PubMed DOI  K  T  I
2015
2. Jiang,K.L., Ma,P.P., Yang,X.Q., Zhong,L., Wang,H., Zhu,X.Y. and Liu,B.Z.
   Neutrophil elastase and its therapeutic effect on leukemia cells
   Mol Med Rep12, 4165-4172. PubMed  Europe PubMed DOI  I
2013
3. Mansuy-Aubert,V., Zhou,Q.L., Xie,X., Gong,Z., Huang,J.Y., Khan,A.R., Aubert,G., Candelaria,K., Thomas,S., Shin,D.J., Booth,S., Baig,S.M., Bilal,A., Hwang,D., Zhang,H., Lovell-Badge,R., Smith,S.R., Awan,F.R. and Jiang,Z.Y.
   Imbalance between neutrophil elastase and its inhibitor alpha1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure
   Cell Metab17, 534-548. PubMed  Europe PubMed DOI  I
2002
4. [YEAR:29-8-2002]Macdonald,S.J., Dowle,M.D., Harrison,L.A., Clarke,G.D., Inglis,G.G., Johnson,M.R., Shah,P., Smith,R.A., Amour,A., Fleetwood,G., Humphreys,D.C., Molloy,C.R., Dixon,M., Godward,R.E., Wonacott,A.J., Singh,O.M., Hodgson,S.T. and Hardy,G.W.
   Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)
   J Med Chem45, 3878-3890. PubMed  Europe PubMed DOI  S  I
2001
5. [YEAR:9-4-2001]Macdonald,S.J., Dowle,M.D., Harrison,L.A., Shah,P., Johnson,M.R., Inglis,G.G., Clarke,G.D., Smith,R.A., Humphreys,D., Molloy,C.R., Amour,A., Dixon,M., Murkitt,G., Godward,R.E., Padfield,T., Skarzynski,T., Singh,O.M., Kumar,K.A., Fleetwood,G., Hodgson,S.T., Hardy,G.W. and Finch,H.
   The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate
   Bioorg Med Chem Lett11, 895-898. PubMed  Europe PubMed DOI  I