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Literature for ZVAD-FMK (C14.003 inhibitor)

Summary Literature

(Topics flags: S Structure, I Inhibitor, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Chang,H., Sun,F., Tian,K., Wang,W., Zhou,K., Zha,D. and Qiu,J.
    Caspase inhibitor z-VAD-FMK increases the survival of hair cells after actinomycin-D-induced damage in vitro
    Neurosci Lett (2020) 732, 135089-135089. PubMed  Europe PubMed DOI  I
  2. Dietz,A., Dalda,N., Zielke,S., Dittmann,J., van Wijk,S.J.L., Vogler,M. and Fulda,S.
    Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis
    Int J Cancer (2020) PubMed  Europe PubMed DOI  I
  3. Pagano,N., Longobardi,V., De Canditiis,C., Zuchegna,C., Romano,A., Michal Andrzej,K., Pero,M.E. and Gasparrini,B.
    Effect of caspase inhibitor Z-VAD-FMK on bovine sperm cryotolerance
    Reprod Domest Anim (2020) 55, 530-536. PubMed  Europe PubMed DOI  I
    4. 2019
  4. Li,X., Yao,X., Zhu,Y., Zhang,H., Wang,H., Ma,Q., Yan,F., Yang,Y., Zhang,J., Shi,H., Ning,Z., Dai,J., Li,Z., Li,C., Su,F., Xue,Y., Meng,X., Dong,G. and Xiong,H.
    The caspase inhibitor Z-VAD-FMK alleviates endotoxic shock via inducing macrophages necroptosis and promoting MDSCs-mediated inhibition of macrophages activation
    Front Immunol (2019) 10, 1824-1824. PubMed  Europe PubMed DOI  PMC  EPMC  I
    5. 2018
  5. Su,W., Han,L., Chen,X., Yu,J., Cheng,X., Huang,J., Xiao,Y., Tian,Y., Olsen,N., Zheng,S.G. and Liang,D.
    Pharmacological inhibition of caspase-8 suppresses inflammation-induced lymphangiogenesis and allograft rejection in the cornea
    J Allergy Clin Immunol (2018) 142, 290-294. PubMed  Europe PubMed DOI  I
  6. Zamaraev,A.V., Kopeina,G.S., Buchbinder,J.H., Zhivotovsky,B. and Lavrik,I.N.
    Caspase-2 is a negative regulator of necroptosis
    Int J Biochem Cell Biol (2018) 102, 101-108. PubMed  Europe PubMed DOI  I
    7. 2016
  7. Cordara,G., van Eerde,A., Grahn,E.M., Winter,H.C., Goldstein,I.J. and Krengel,U.
    An unusual member of the papain superfamily: mapping the catalytic cleft of the Marasmius oreades agglutinin (MOA) with a caspase inhibitor
    PLoS ONE (2016) 11, e0149407-e0149407. PubMed  Europe PubMed DOI  S  I
  8. Kim,M.S., Lee,J.A. and Kim,K.H.
    Effects of a broad-spectrum caspase inhibitor, Z-VAD(OMe)-FMK, on viral hemorrhagic septicemia virus (VHSV) infection-mediated apoptosis and viral replication
    Fish Shellfish Immunol (2016) 51, 41-45. PubMed  Europe PubMed DOI  I
  9. Liu,M., Shi,L., Zou,X., Zheng,X., Zhang,F., Ding,X., Zhu,H. and Shen,Y.
    Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis
    Pancreatology (2016) 16, 733-738. PubMed  Europe PubMed DOI  I
    10. 2015
  10. van den Berg,E., Bal,S.M., Kuipers,M.T., Matute-Bello,G., Lutter,R., Bos,A.P., van Woensel,J.B. and Bem,R.A.
    The caspase inhibitor zVAD increases lung inflammation in pneumovirus infection in mice
    Physiol Rep (2015) 3 PubMed  Europe PubMed DOI  I
  11. Wang,Q., Li,C., Peng,X., Kang,Q., Deng,D., Zhang,L., Zheng,Y., Wang,C., Qiao,Z., Guo,D., You,S. and Tang,H.
    Combined treatment of carfilzomib and z-VAD-fmk inhibits skeletal proteolysis and apoptosis and ameliorates cancer cachexia
    Med Oncol (2015) 32, 100-100. PubMed  Europe PubMed DOI  I
  12. Werthmoller,N., Frey,B., Wunderlich,R., Fietkau,R. and Gaipl,U.S.
    Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner
    Cell Death Dis (2015) 6, e1761- PubMed  Europe PubMed DOI  I
    13. 2014
  13. Hight,M.R., Cheung,Y.Y., Nickels,M.L., Dawson,E.S., Zhao,P., Saleh,S., Buck,J.R., Tang,D., Washington,M.K., Coffey,R.J. and Manning,H.C.
    A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells
    Clin Cancer Res (2014) 20, 2126-2135. PubMed  Europe PubMed DOI  L  I
  14. Li,J., Lin,L., Du,L., Xu,C., Wang,Y., Cao,J., Wang,Q., Fan,F., Wang,X., Wang,Y. and Liu,Q.
    Radioprotective effect of a pan-caspase inhibitor in a novel model of radiation injury to the nucleus of the abducens nerve
    Mol Med Rep (2014) 10, 1433-1437. PubMed  Europe PubMed DOI  I
  15. McStay,G.P. and Green,D.R.
    Identification of active caspases using affinity-based probes
    Cold Spring Harb Protoc (2014) 2014, 856-860. PubMed  Europe PubMed DOI  I
    16. 2013
  16. Castro,M.M., Fuah,J., Ali,M., Sung,M., Schulz,J., Kondo,M.Y., Fan,X., Holt,A. and Schulz,R.
    Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2
    Biochem Pharmacol (2013) 86, 469-475. PubMed  Europe PubMed DOI  I
  17. Fricker,M., Vilalta,A., Tolkovsky,A.M. and Brown,G.C.
    Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia
    J Biol Chem (2013) 288, 9145-9152. PubMed  Europe PubMed DOI  I
  18. Gradl,G., Herlyn,P., Finke,B., Gierer,P., Wree,A., Witt,M., Mittlmeier,T. and Vollmar,B.
    A pan-caspase inhibitor reduces myocyte apoptosis and neuropathic pain in rats with chronic constriction injury of the sciatic nerve
    Anesth Analg (2013) 116, 216-223. PubMed  Europe PubMed DOI  I
  19. Igietseme,J.U., Omosun,Y., Partin,J., Goldstein,J., He,Q., Joseph,K., Ellerson,D., Ansari,U., Eko,F.O., Bandea,C., Zhong,G. and Black,C.M.
    Prevention of Chlamydia-induced infertility by inhibition of local caspase activity
    J Infect Dis (2013) 207, 1095-1104. PubMed  Europe PubMed DOI  I
    20. 2012
  20. Lawrence,C.P. and Chow,S.C.
    Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties
    Toxicol Appl Pharmacol (2012) 265, 103-112. PubMed  Europe PubMed DOI  I
  21. Li,Y.Y. and Yan,C.L.
    [Inhibition of elicitation of allergic contact dermatitis by topical use of Z-VAD-FMK, a broad caspase inhibitor: experiment in mice]
    Zhonghua Yi Xue Za Zhi (2012) 92, 1992-1996. PubMed  Europe PubMed DOI  I
  22. Prudnikov,I.M. and Smirnov,A.N.
    Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases
    J Biochem (2012) 151, 299-316. PubMed  Europe PubMed DOI  I
  23. Rodriguez-Enfedaque,A., Delmas,E., Guillaume,A., Gaumer,S., Mignotte,B., Vayssiere,J.L. and Renaud,F.
    zVAD-fmk upregulates caspase-9 cleavage and activity in etoposide-induced cell death of mouse embryonic fibroblasts
    Biochim Biophys Acta (2012) 1823, 1343-1352. PubMed  Europe PubMed DOI  I
    24. 2011
  24. Ivanova,S., Gregorc,U., Vidergar,N., Javier,R., Bredt,D.S., Vandenabeele,P., Pardo,J., Simon,M.M., Turk,V., Banks,L. and Turk,B.
    MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis
    Cell Death Dis (2011) 2, e116-e116. PubMed  Europe PubMed DOI  PMC  EPMC  I
  25. Muller,I., Lamers,M.B., Ritchie,A.J., Dominguez,C., Munoz-Sanjuan,I. and Kiselyov,A.
    Structure of human caspase-6 in complex with Z-VAD-FMK: new peptide binding mode observed for the non-canonical caspase conformation
    Bioorg Med Chem Lett (2011) 21, 5244-5247. PubMed  Europe PubMed DOI  I
  26. Teng,B.T., Tam,E.W., Benzie,I.F. and Siu,P.M.
    Protective effect of caspase inhibition on compression-induced muscle damage
    J Physiol (2011) 589, 3349-3369. PubMed  Europe PubMed DOI  I
    27. 2010
  27. Imai,Y., Adachi,Y., Shi,M., Shima,C., Yanai,S., Okigaki,M., Yamashima,T., Kaneko,K. and Ikehara,S.
    Caspase inhibitor ZVAD-fmk facilitates engraftment of donor hematopoietic stem cells in intra-bone marrow-bone marrow transplantation
    Stem Cells Dev (2010) 19, 461-468. PubMed  Europe PubMed DOI  I
  28. Lafont,E., Milhas,D., Teissie,J., Therville,N., Andrieu-Abadie,N., Levade,T., Benoist,H. and Segui,B.
    Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk
    PLoS ONE (2010) 5, e13638-e13638. PubMed  Europe PubMed DOI  PMC  EPMC  I
    29. 2008
  29. Li,Y.Y., Yan,C.L. and Xu,W.
    [Attenuation of allergic contact dermatitis by Z-VAD-FMK, a broad caspase inhibitor: experiment with mice]
    Zhonghua Yi Xue Za Zhi (2008) 88, 3153-3156. PubMed  Europe PubMed  I
  30. Mersmann,J., Zacharowski,P.A., Schmitz,I. and Zacharowski,K.
    Caspase inhibitor zVAD.fmk reduces infarct size after myocardial ischaemia and reperfusion in rats but not in mice
    Resuscitation (2008) 79, 468-474. PubMed  Europe PubMed DOI  I
    31. 2007
  31. Markina,E.V., Storozheva,Z.I., Yurasov,V.V. and Sherstnev,V.V.
    Central injection of caspase inhibitors facilitates the formation of freezing behavior in rats
    Bull Exp Biol Med (2007) 143, 566-568. PubMed  Europe PubMed DOI  I
  32. Martin,U., Jarasch,N., Nestler,M., Rassmann,A., Munder,T., Seitz,S., Zell,R., Wutzler,P. and Henke,A.
    Antiviral effects of pan-caspase inhibitors on the replication of coxsackievirus B3
    Apoptosis (2007) 12, 525-533. PubMed  Europe PubMed DOI  I
  33. Silva,E.M., Guillermo,L.V., Ribeiro-Gomes,F.L., De Meis,J., Nunes,M.P., Senra,J.F., Soares,M.B., DosReis,G.A. and Lopes,M.F.
    Caspase inhibition reduces lymphocyte apoptosis and improves host immune responses to Trypanosoma cruzi infection
    Eur J Immunol (2007) 37, 738-746. PubMed  Europe PubMed DOI  I
    34. 2006
  34. [YEAR:30-5-2006]D'Lima,D., Hermida,J., Hashimoto,S., Colwell,C. and Lotz,M.
    Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis
    Arthritis Rheum (30-5-2006) 54, 1814-1821. PubMed  Europe PubMed DOI  I
  35. Deszcz,L., Cencic,R., Sousa,C., Kuechler,E. and Skern,T.
    An antiviral peptide inhibitor that is active against picornavirus 2A proteinases but not cellular caspases
    J Virol (2006) 80, 9619-9627. PubMed  Europe PubMed DOI  I
  36. Martinet,W., Schrijvers,D.M., Herman,A.G. and De Meyer,G.R.
    z-VAD-fmk-induced non-apoptotic cell death of macrophages: possibilities and limitations for atherosclerotic plaque stabilization
    Autophagy (2006) 2, 312-314. PubMed  Europe PubMed  I
  37. Misaghi,S., Korbel,G.A., Kessler,B., Spooner,E. and Ploegh,H.L.
    z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress
    Cell Death Differ (2006) 13, 163-165. PubMed  Europe PubMed DOI  I
  38. [YEAR:24-10-2006]Vandenabeele,P., Vanden Berghe,T. and Festjens,N.
    Caspase inhibitors promote alternative cell death pathways
    Sci STKE (24-10-2006) 2006, e44-e44. PubMed  Europe PubMed DOI  I
  39. [YEAR:31-12-2006]Yee,S.B., Baek,S.J., Park,H.T., Jeong,S.H., Jeong,J.H., Kim,T.H., Kim,J.M., Jeong,B.K., Park,B.S., Kwon,T.K., Yoon,I. and Yoo,Y.H.
    zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells
    Exp Mol Med (31-12-2006) 38, 634-642. PubMed  Europe PubMed DOI  I
    40. 2005
  40. [YEAR:1-4-2005]Cowburn,A.S., White,J.F., Deighton,J., Walmsley,S.R. and Chilvers,E.R.
    z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species
    Blood (1-4-2005) 105, 2970-2972. PubMed  Europe PubMed DOI  I
  41. Huang,J., Wu,L., Tashiro,S., Onodera,S. and Ikejima,T.
    The augmentation of TNFalpha-induced cell death in murine L929 fibrosarcoma by the pan-caspase inhibitor Z-VAD-fmk through pre-mitochondrial and MAPK-dependent pathways
    Acta Med Okayama (2005) 59, 253-260. PubMed  Europe PubMed  I
  42. Montolio,M., Tellez,N., Biarnes,M., Soler,J. and Montanya,E.
    Short-term culture with the caspase inhibitor z-VAD.fmk reduces beta cell apoptosis in transplanted islets and improves the metabolic outcome of the graft
    Cell Transplant (2005) 14, 59-65. PubMed  Europe PubMed  I
    43. 2004
  43. Clark,P., Dziarmaga,A., Eccles,M. and Goodyer,P.
    Rescue of defective branching nephrogenesis in renal-coloboma syndrome by the caspase inhibitor, Z-VAD-fmk
    J Am Soc Nephrol (2004) 15, 299-305. PubMed  Europe PubMed DOI  I
  44. DeBiasi,R.L., Robinson,B.A., Sherry,B., Bouchard,R., Brown,R.D., Rizeq,M., Long,C. and Tyler,K.L.
    Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo
    J Virol (2004) 78, 11040-11050. PubMed  Europe PubMed DOI  PMC  EPMC  I
  45. [YEAR:27-2-2004]Deszcz,L., Seipelt,J., Vassilieva,E., Roetzer,A. and Kuechler,E.
    Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase
    FEBS Lett (27-2-2004) 560, 51-55. PubMed  Europe PubMed DOI  I
  46. Malyshev,I.Y., Pshennikova,M.G., Shimkovich,M.V. and Malysheva,E.V.
    Caspase inhibitor Z-VAD-FMK potentiates heat shock-induced apoptosis and HSP70 synthesis in macrophages
    Bull Exp Biol Med (2004) 138, 230-232. PubMed  Europe PubMed DOI  I
    47. 2003
  47. [YEAR:15-8-2003]Ilangovan,R., Marshall,W.L., Hua,Y. and Zhou,J.
    Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells
    J Biol Chem (15-8-2003) 278, 30993-30999. PubMed  Europe PubMed DOI  I
    48. 2002
  48. [YEAR:15-7-2002]Chen,J., Li,Y., Wang,L., Lu,M. and Chopp,M.
    Caspase inhibition by Z-VAD increases the survival of grafted bone marrow cells and improves functional outcome after MCAo in rats
    J Neurol Sci (15-7-2002) 199, 17-24. PubMed  Europe PubMed DOI  I
    49. 2001
  49. Van Noorden,C.J.
    The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition
    Acta Histochem (2001) 103, 241-251. PubMed  Europe PubMed DOI  V  I
    50. 2000
  50. Kim,W.J., Mohan,R.R., Mohan,R.R. and Wilson,S.E.
    Caspase inhibitor z-VAD-FMK inhibits keratocyte apoptosis, but promotes keratocyte necrosis, after corneal epithelial scrape
    Exp Eye Res (2000) 71, 225-232. PubMed  Europe PubMed DOI  I
    51. 1999
  51. [YEAR:20-12-1999]Alam,A., Cohen,L.Y., Aouad,S. and Sekaly,R.P.
    Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells
    J Exp Med (20-12-1999) 190, 1879-1890. PubMed  Europe PubMed DOI  PMC  EPMC  I
  52. [YEAR:8-1-1999]Schotte,P., Declercq,W., Van Huffel,S., Vandenabeele,P. and Beyaert,R.
    Non-specific effects of methyl ketone peptide inhibitors of caspases
    FEBS Lett (8-1-1999) 442, 117-121. PubMed  Europe PubMed DOI  I
    53. 1998
  53. [YEAR:1-5-1998]Chandler,J.M., Cohen,G.M. and MacFarlane,M.
    Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver
    J Biol Chem (1-5-1998) 273, 10815-10818. PubMed  Europe PubMed DOI  I
  54. [YEAR:4-12-1998]Garcia-Calvo,M., Peterson,E.P., Leiting,B., Ruel,R., Nicholson,D.W. and Thornberry,N.A.
    Inhibition of human caspases by peptide-based and macromolecular inhibitors
    J Biol Chem (4-12-1998) 273, 32608-32613. PubMed  Europe PubMed DOI  I
  55. [YEAR:27-1-1998]Yaoita,H., Ogawa,K., Maehara,K. and Maruyama,Y.
    Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor
    Circulation (27-1-1998) 97, 276-281. PubMed  Europe PubMed  I
    56. 1997
  56. [YEAR:4-9-1997]Qi,X.M., He,H., Zhong,H. and Distelhorst,C.W.
    Baculovirus p35 and Z-VAD-fmk inhibit thapsigargin-induced apoptosis of breast cancer cells
    Oncogene (4-9-1997) 15, 1207-1212. PubMed  Europe PubMed DOI  I
    57. 1996
  57. [YEAR:17-6-1996]Loddick,S.A., Mackenzie,A. and Rothwell,N.J.
    An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat
    Neuroreport (17-6-1996) 7, 1465-1468. PubMed  Europe PubMed  I
  58. Pronk,G.J., Ramer,K., Amiri,P. and Williams,L.T.
    Requirement of an ice-like protease for induction of apoptosis and ceramide generation by reaper
    Science (1996) 271, 808-810. PubMed  Europe PubMed  I
  59. [YEAR:1-11-1996]Rodriguez,I., Matsuura,K., Ody,C., Nagata,S. and Vassalli,P.
    Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death
    J Exp Med (1-11-1996) 184, 2067-2072. PubMed  Europe PubMed  PMC  EPMC  I
  60. [YEAR:1-12-1996]Sarin,A., Wu,M.L. and Henkart,P.A.
    Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli
    J Exp Med (1-12-1996) 184, 2445-2450. PubMed  Europe PubMed DOI  PMC  EPMC  I
  61. [YEAR:1-4-1996]Slee,E.A., Zhu,H., Chow,S.C., MacFarlane,M., Nicholson,D.W. and Cohen,G.M.
    Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
    Biochem J (1-4-1996) 315, 21-24. PubMed  Europe PubMed  PMC  EPMC  I
    62. 1995
  62. Fearnhead,H.O., Dinsdale,D. and Cohen,G.M.
    An interleukin-1beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes
    FEBS Lett (1995) 375, 283-288. PubMed  Europe PubMed DOI  I

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