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Literature for CGS27023A (M10.004 inhibitor)

Summary Structure Literature Inhibits

(Topics flags: S Structure, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2015
  1. Behrends,M., Wagner,S., Kopka,K., Schober,O., Schafers,M., Kumbhar,S., Waller,M. and Haufe,G.
    New matrix metalloproteinase inhibitors based on gamma-fluorinated alpha-aminocarboxylic and alpha-aminohydroxamic acids
    Bioorg Med Chem (2015) 23, 3809-3818. PubMed  Europe PubMed DOI  I
    2. 2012
  2. Kovacs,H., Agback,T. and Isaksson,J.
    Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy
    J Biomol NMR (2012) 53, 85-92. PubMed  Europe PubMed DOI  I
    3. 2009
  3. Nishizawa,S., Yamaoka,H., Matsui,M., Hirabayashi,S., Hoshi,K., Koshima,I. and Yamaoka,K.
    Selection and effect of ointment bases for preparing collagenase inhibitor ointment using high-performance liquid chromatography and Franz cell apparatus
    Ann Plast Surg (2009) 62, 187-193. PubMed  Europe PubMed DOI  I
  4. Romero-Perez,D., Agrawal,A., Jacobsen,J., Yan,Y., Thomas,R., Cohen,S. and Villarreal,F.
    Effects of novel semiselective matrix metalloproteinase inhibitors on ex vivo cardiac structure-function
    J Cardiovasc Pharmacol (2009) 53, 452-461. PubMed  Europe PubMed DOI  PMC  EPMC  I
  5. Wagner,S., Breyholz,H.J., Holtke,C., Faust,A., Schober,O., Schafers,M. and Kopka,K.
    A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: radiosynthesis and initial small-animal PET studies
    Appl Radiat Isot (2009) 67, 606-610. PubMed  Europe PubMed DOI  I
    6. 2008
  6. Cheng,X.C., Wang,Q., Fang,H. and Xu,W.F.
    Role of sulfonamide group in matrix metalloproteinase inhibitors
    Curr Med Chem (2008) 15, 368-373. PubMed  Europe PubMed DOI  I
  7. Kasaoka,T., Nishiyama,H., Okada,M. and Nakajima,M.
    Matrix metalloproteinase inhibitor, MMI270 (CGS27023A) inhibited hematogenic metastasis of B16 melanoma cells in both experimental and spontaneous metastasis models
    Clin Exp Metastasis (2008) 25, 827-834. PubMed  Europe PubMed DOI  I
  8. Ouchi,H., Fujita,M., Ikegame,S., Ye,Q., Inoshima,I., Harada,E., Kuwano,K. and Nakanishi,Y.
    The role of collagenases in experimental pulmonary fibrosis
    Pulm Pharmacol Ther (2008) 21, 401-408. PubMed  Europe PubMed DOI  I
  9. Yang,S.M., Scannevin,R.H., Wang,B., Burke,S.L., Huang,Z., Karnachi,P., Wilson,L.J., Rhodes,K.J., Lagu,B. and Murray,W.V.
    beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents
    Bioorg Med Chem Lett (2008) 18, 1140-1145. PubMed  Europe PubMed DOI  I
  10. Yang,S.M., Scannevin,R.H., Wang,B., Burke,S.L., Wilson,L.J., Karnachi,P., Rhodes,K.J., Lagu,B. and Murray,W.V.
    beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. design, synthesis, and lead identification
    Bioorg Med Chem Lett (2008) 18, 1135-1139. PubMed  Europe PubMed DOI  I
    11. 2007
  11. Breyholz,H.J., Wagner,S., Levkau,B., Schober,O., Schafers,M. and Kopka,K.
    A 18F-radiolabeled analogue of CGS 27023A as a potential agent for assessment of matrix-metalloproteinase activity in vivo
    Q J Nucl Med Mol Imaging (2007) 51, 24-32. PubMed  Europe PubMed  I
  12. Wagner,S., Breyholz,H.J., Law,M.P., Faust,A., Holtke,C., Schroer,S., Haufe,G., Levkau,B., Schober,O., Schafers,M. and Kopka,K.
    Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET
    J Med Chem (2007) 50, 5752-5764. PubMed  Europe PubMed DOI  L  I
    13. 2006
  13. Medina,C., Santana,A., Paz,M.C., Diaz-Gonzalez,F., Farre,E., Salas,A., Radomski,M.W. and Quintero,E.
    Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis
    J Leukoc Biol (2006) 79, 954-962. PubMed  Europe PubMed DOI  I
  14. Ogata,Y., Matono,K., Nakajima,M., Sasatomi,T., Mizobe,T., Nagase,H. and Shirouzu,K.
    Efficacy of the MMP inhibitor MMI270 against lung metastasis following removal of orthotopically transplanted human colon cancer in rat
    Int J Cancer (2006) 118, 215-221. PubMed  Europe PubMed DOI  I
  15. [YEAR:14-2-2006]Tuccinardi,T., Martinelli,A., Nuti,E., Carelli,P., Balzano,F., Uccello-Barretta,G., Murphy,G. and Rossello,A.
    Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides
    Bioorg Med Chem (14-2-2006) 14, 4260-4276. PubMed  Europe PubMed DOI  I
    16. 2005
  16. Amano,S., Ogura,Y., Akutsu,N., Matsunaga,Y., Kadoya,K., Adachi,E. and Nishiyama,T.
    Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoageing process
    Br J Dermatol (2005) 153 Suppl 2, 37-46. PubMed  Europe PubMed DOI  I
  17. Eatock,M., Cassidy,J., Johnson,J., Morrison,R., Devlin,M., Blackey,R., Owen,S., Choi,L. and Twelves,C.
    A dose-finding and pharmacokinetic study of the matrix metalloproteinase inhibitor MMI270 (previously termed CGS27023A) with 5-FU and folinic acid
    Cancer Chemother Pharmacol (2005) 55, 39-46. PubMed  Europe PubMed DOI  I
  18. Mizuno,S., Matsumoto,K., Li,M.Y. and Nakamura,T.
    HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis
    FASEB J (2005) 19, 580-582. PubMed  Europe PubMed DOI  I
    19. 2004
  19. DiMicco,M.A., Patwari,P., Siparsky,P.N., Kumar,S., Pratta,M.A., Lark,M.W., Kim,Y.J. and Grodzinsky,A.J.
    Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury
    Arthritis Rheum (2004) 50, 840-848. PubMed  Europe PubMed DOI  I
  20. Kopka,K., Breyholz,H.J., Wagner,S., Law,M.P., Riemann,B., Schroer,S., Trub,M., Guilbert,B., Levkau,B., Schober,O. and Schafers,M.
    Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivo
    Nucl Med Biol (2004) 31, 257-267. PubMed  Europe PubMed DOI  I
  21. Majumdar,T.K., Vedananda,S. and Tse,F.L.
    Rapid analysis of MMI270B, an inhibitor of matrix metalloproteases in human plasma by liquid chromatography-tandem mass spectrometry: matrix interference in patient samples
    Biomed Chromatogr (2004) 18, 77-85. PubMed  Europe PubMed DOI  I
  22. [YEAR:1-5-2004]Rossello,A., Nuti,E., Orlandini,E., Carelli,P., Rapposelli,S., Macchia,M., Minutolo,F., Carbonaro,L., Albini,A., Benelli,R., Cercignani,G., Murphy,G. and Balsamo,A.
    New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)
    Bioorg Med Chem (1-5-2004) 12, 2441-2450. PubMed  Europe PubMed DOI  I
  23. Schafers,M., Riemann,B., Kopka,K., Breyholz,H.J., Wagner,S., Schafers,K.P., Law,M.P., Schober,O. and Levkau,B.
    Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivo
    Circulation (2004) 109, 2554-2559. PubMed  Europe PubMed DOI  I
    24. 2003
  24. Kawai,N., Kawanishi,M. and Nagao,S.
    Treatment of cold injury-induced brain edema with a nonspecific matrix metalloproteinase inhibitor MMI270 in rats
    Acta Neurochir Suppl (2003) 86, 291-295. PubMed  Europe PubMed  I
  25. Medina,C., Videla,S., Radomski,A., Radomski,M.W., Antolin,M., Guarner,F., Vilaseca,J., Salas,A. and Malagelada,J.R.
    Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis
    Am J Physiol Gastrointest Liver Physiol (2003) 284, G116-G122. PubMed  Europe PubMed DOI  I
  26. Nakamura,E.S., Koizumi,K., Yamaura,T. and Saiki,I.
    Anti-tumor angiogenic effect of a matrix metalloproteinase inhibitor MMI270
    Anticancer Res (2003) 23, 411-417. PubMed  Europe PubMed  I
  27. [YEAR:15-12-2003]Xue,C.B., He,X., Roderick,J., Corbett,R.L., Duan,J.J., Liu,R.Q., Covington,M.B., Newton,R.C., Trzaskos,J.M., Magolda,R.L., Wexler,R.R. and Decicco,C.P.
    Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification
    Bioorg Med Chem Lett (15-12-2003) 13, 4293-4297. PubMed  Europe PubMed DOI  I
    28. 2002
  28. Zheng,Q.H., Fei,X., Liu,X., Wang,J.Q., Bin Sun,H., Mock,B.H., Lee Stone,K., Martinez,T.D., Miller,K.D., Sledge,G.W. and Hutchins,G.D.
    Synthesis and preliminary biological evaluation of MMP inhibitor radiotracers [11C]methyl-halo-CGS 27023A analogs, new potential PET breast cancer imaging agents
    Nucl Med Biol (2002) 29, 761-770. PubMed  Europe PubMed DOI  I
    29. 2001
  29. Levitt,N.C., Eskens,F.A., O'Byrne,K.J., Propper,D.J., Denis,L.J., Owen,S.J., Choi,L., Foekens,J.A., Wilner,S., Wood,J.M., Nakajima,M., Talbot,D.C., Steward,W.P., Harris,A.L. and Verweij,J.
    Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer
    Clin Cancer Res (2001) 7, 1912-1922. PubMed  Europe PubMed  I
  30. [YEAR:28-9-2001]Nar,H., Werle,K., Bauer,M.M., Dollinger,H. and Jung,B.
    Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor
    J Mol Biol (28-9-2001) 312, 743-751. PubMed  Europe PubMed DOI  S  I
    31. 2000
  31. Eskens,F.A., Levitt,N.C., Sparreboom,A., Choi,L., Mather,R., Verweij,J. and Harris,A.L.
    Effect of food on the pharmacokinetics of oral MMI270B (CGS 27023A), a novel matrix metalloproteinase inhibitor
    Clin Cancer Res (2000) 6, 431-433. PubMed  Europe PubMed  I
  32. Lee,P.P., Hwang,J.J., Murphy,G. and Ip,M.M.
    Functional significance of MMP-9 in tumor necrosis factor-induced proliferation and branching morphogenesis of mammary epithelial cells
    Endocrinology (2000) 141, 3764-3773. PubMed  Europe PubMed DOI  I
  33. [YEAR:22-9-2000]Moy,F.J., Chanda,P.K., Chen,J.M., Cosmi,S., Edris,W., Levin,J.I. and Powers,R.
    High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor
    J Mol Biol (22-9-2000) 302, 671-689. PubMed  Europe PubMed DOI  S  I
    34. 1999

  34. CGS 27023A. CDG 27023A
    Drugs R D (1999) 1, 144-145. PubMed  Europe PubMed  I
  35. De,B., Natchus,M.G., Cheng,M., Pikul,S., Almstead,N.G., Taiwo,Y.O., Snider,C.E., Chen,L., Barnett,B., Gu,F. and Dowty,M.
    The next generation of MMP inhibitors. Design and synthesis
    Ann N Y Acad Sci (1999) 878, 40-60. PubMed  Europe PubMed DOI  I
  36. Ganu,V., Melton,R., Wang,W. and Roberts,D.
    Matrix metalloproteinase inhibitor CGS 27023A protects COMP and proteoglycan in the bovine articular cartilage but not the release of their fragments from cartilage after prolonged stimulation in vitro with IL-1 alpha
    Ann N Y Acad Sci (1999) 878, 607-611. PubMed  Europe PubMed DOI  I
  37. [YEAR:1-6-1999]Moy,F.J., Chanda,P.K., Chen,J.M., Cosmi,S., Edris,W., Skotnicki,J.S., Wilhelm,J. and Powers,R.
    NMR solution structure of the catalytic fragment of human fibroblast collagenase complexed with a sulfonamide derivative of a hydroxamic acid compound
    Biochemistry (1-6-1999) 38, 7085-7096. PubMed  Europe PubMed DOI  S  I
  38. Prescott,M.F., Sawyer,W.K., Von Linden-Reed,J., Jeune,M., Chou,M., Caplan,S.L. and Jeng,A.Y.
    Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury
    Ann N Y Acad Sci (1999) 878, 179-190. PubMed  Europe PubMed DOI  I
    39. 1998
  39. Brown,P.D.
    Matrix metalloproteinase inhibitors
    Angiogenesis (1998) 1, 142-154. PubMed  Europe PubMed DOI  I
  40. Ganu,V., Goldberg,R., Peppard,J., Rediske,J., Melton,R., Hu,S.I., Wang,W., Duvander,C. and Heinegard,D.
    Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid
    Arthritis Rheum (1998) 41, 2143-2151. PubMed  Europe PubMed DOI  I
    41. 1997
  41. Doughty,J.R., O'Byrne,E., Spirito,S., Blancuzzi,V., Singh,H.N. and Goldberg,R.L.
    The effect of CGS 27023A on the level of 3B3 (-) epitope in a rabbit meniscectomy model
    Inflamm Res (1997) 46 Suppl 2, S139-S140. PubMed  Europe PubMed  I
  42. MacPherson,L.J., Bayburt,E.K., Capparelli,M.P., Carroll,B.J., Goldstein,R., Justice,M.R., Zhu,L., Hu,S., Melton,R.A., Fryer,L., Goldberg,R.L., Doughty,J.R., Spirito,S., Blancuzzi,V., Wilson,D., O'Byrne,E.M., Ganu,V. and Parker,D.T.
    Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits
    J Med Chem (1997) 40, 2525-2532. PubMed  Europe PubMed DOI  I
    43. 1995
  43. O'Byrne,E.M., Parker,D.T., Roberts,E.D., Goldberg,R.L., MacPherson,L.J., Blancuzzi,V., Wilson,D., Singh,H.N., Ludewig,R. and Ganu,V.S.
    Oral administration of a matrix metalloproteinase inhibitor, CGS 27023A, protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits
    Inflamm Res (1995) 44 Suppl 2, S117-S118. PubMed  Europe PubMed DOI  I

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