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Literature for CA074 (C01.060 inhibitor)

Summary Structure Literature Inhibits

(Topics flags: S Structure, T Target, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Jiang,M., Meng,J., Zeng,F., Qing,H., Hook,G., Hook,V., Wu,Z. and Ni,J.
    Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling
    J Neurochem (2020) PubMed  Europe PubMed DOI  I
    2. 2018
  2. Coleman,M.D., Ha,S.D., Haeryfar,S.M.M., Barr,S.D. and Kim,S.O.
    Cathepsin B plays a key role in optimal production of the influenza A virus
    J Virol Antivir Res (2018) 2018, 1-20. PubMed  Europe PubMed DOI  PMC  EPMC  I
  3. Dietze,R., Starzinski-Powitz,A., Scheiner-Bobis,G., Tinneberg,H.R., Meinhold-Heerlein,I. and Konrad,L.
    Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells
    Biochim Biophys Acta Mol Cell Biol Lipids (2018) 1863, 1369-1377. PubMed  Europe PubMed DOI  I
  4. Gonzalez,E.A., Martins,G.R., Tavares,A.M.V., Viegas,M., Poletto,E., Giugliani,R., Matte,U. and Baldo,G.
    Cathepsin B inhibition attenuates cardiovascular pathology in mucopolysaccharidosis I mice
    Life Sci (2018) 196, 102-109. PubMed  Europe PubMed DOI  I
  5. Llorente,P., Kristen,H., Sastre,I., Toledano-Zaragoza,A., Aldudo,J., Recuero,M. and Bullido,M.J.
    A free radical-generating system regulates amyloid oligomers: involvement of cathepsin B
    J Alzheimers Dis (2018) 66, 1397-1408. PubMed  Europe PubMed DOI  I
  6. Tang,Y., Cao,G., Min,X., Wang,T., Sun,S., Du,X. and Zhang,W.
    Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation
    J Physiol Biochem (2018) 74, 503-510. PubMed  Europe PubMed DOI  I
    7. 2017
  7. Shoji,A., Suenaga,Y., Hosaka,A., Ishida,Y., Yanagida,A. and Sugawara,M.
    Inhibitory assay for degradation of collagen IV by cathepsin B with a surface plasmon resonance sensor
    J Pharm Biomed Anal (2017) 145, 79-83. PubMed  Europe PubMed DOI  I
  8. Wu,Z., Ni,J., Liu,Y., Teeling,J.L., Takayama,F., Collcutt,A., Ibbett,P. and Nakanishi,H.
    Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice
    Brain Behav Immun (2017) 65, 350-361. PubMed  Europe PubMed DOI  I
    9. 2016
  9. Xu,Y., Wang,J., Song,X., Wei,R., He,F., Peng,G. and Luo,B.
    Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats
    Brain Res Bull (2016) 120, 97-105. PubMed  Europe PubMed DOI  I
  10. Zuo,X., Hou,Q., Jin,J., Zhan,L., Li,X., Sun,W., Lin,K. and Xu,E.
    Inhibition of cathepsin B alleviates secondary degeneration in ipsilateral thalamus after focal cerebral infarction in adult rats
    J Neuropathol Exp Neurol (2016) 75, 816-826. PubMed  Europe PubMed DOI  I
    11. 2015
  11. Mashamba-Thompson,T. and Soliman,M.E.S.
    Insight into the binding theme of CA-074Me to cathepsin B: molecular dynamics simulations and scaffold hopping to identify potential analogues as anti-neurodegenerative diseases
    Med Chem Res (2015) 24, 701-713. DOI  I
  12. Patel,N., Nizami,S., Song,L., Mikami,M., Hsu,A., Hickernell,T., Chandhanayingyong,C., Rho,S., Compton,J.T., Caldwell,J.M., Kaiser,P.B., Bai,H., Lee,H.G., Fischer,C.R. and Lee,F.Y.
    CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-Fos signaling pathways
    J Orthop Res (2015) 33, 1474-1486. PubMed  Europe PubMed DOI  I
  13. Zhang,L., Fu,X.H., Yu,Y., Shui,R.H., Li,C., Zeng,H.Y., Qiao,Y.L., Ni,L.Y. and Wang,Q.
    Treatment with CA-074Me, a cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis
    Lab Invest (2015) 95, 65-77. PubMed  Europe PubMed DOI  I
    14. 2013
  14. Cho,K., Yoon,S.Y., Choi,J.E., Kang,H.J., Jang,H.Y. and Kim,D.H.
    CA-074Me, a cathepsin B inhibitor, decreases APP accumulation and protects primary rat cortical neurons treated with okadaic acid
    Neurosci Lett (2013) 548, 222-227. PubMed  Europe PubMed DOI  I
  15. Feng,Y., Ni,L. and Wang,Q.
    Administration of cathepsin B inhibitor CA-074Me reduces inflammation and apoptosis in polymyositis
    J Dermatol Sci (2013) 72, 158-167. PubMed  Europe PubMed DOI  I
  16. Liu,A., Gao,X., Zhang,Q. and Cui,L.
    Cathepsin B inhibition attenuates cardiac dysfunction and remodeling following myocardial infarction by inhibiting the NLRP3 pathway
    Mol Med Rep (2013) 8, 361-366. PubMed  Europe PubMed DOI  T  I
  17. Yan,B.Z., Chen,L.Y., Kang,L., Wang,X.R., Bi,M.R., Wang,W. and Yang,B.S.
    Hepatoprotective effects of cathepsin B inhibitor on acute hepatic failure induced by lipopolysaccharide/D-galactosamine in mice
    Hepatobiliary Pancreat Dis Int (2013) 12, 80-86. PubMed  Europe PubMed DOI  I
    18. 2012
  18. Ha,S.D., Park,S., Hattlmann,C.J., Barr,S.D. and Kim,S.O.
    Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells
    Antiviral Res (2012) 93, 175-184. PubMed  Europe PubMed DOI  I
  19. Ni,H., Yan,J.Z., Zhang,L.L., Feng,X. and Wu,X.R.
    Long-term effects of recurrent neonatal seizures on neurobehavioral function and related gene expression and its intervention by inhibitor of cathepsin B
    Neurochem Res (2012) 37, 31-39. PubMed  Europe PubMed DOI  I
  20. Withana,N.P., Blum,G., Sameni,M., Slaney,C., Anbalagan,A., Olive,M.B., Bidwell,B.N., Edgington,L., Wang,L., Moin,K., Sloane,B.F., Anderson,R.L., Bogyo,M.S. and Parker,B.S.
    Cathepsin B inhibition limits bone metastasis in breast cancer
    Cancer Res (2012) 72, 1199-1209. PubMed  Europe PubMed DOI  I
    21. 2011
  21. Jilkova,A., Rezacova,P., Lepsik,M., Horn,M., Vachova,J., Fanfrlik,J., Brynda,J., McKerrow,J.H., Caffrey,C.R. and Mares,M.
    Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni
    J Biol Chem (2011) 286, 35770-35781. PubMed  Europe PubMed DOI  S  I
  22. Steverding,D.
    The cathepsin B-selective inhibitors CA-074 and CA-074Me inactivate cathepsin L under reducing conditions
    Open Enzyme Inhib J (2011) 4, 11-16. DOI  I
  23. Victor,B.C., Anbalagan,A., Mostafa Mohamed,M., Sloane,B.F. and Cavallo-Medved,D.
    Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
    Breast Cancer Res (2011) 13, R115-R115. PubMed  Europe PubMed DOI  I
    24. 2010
  24. Bien,S., Rimmbach,C., Neumann,H., Niessen,J., Reimer,E., Ritter,C.A., Rosskopf,D., Cinatl,J., Michaelis,M., Schroeder,H.W. and Kroemer,H.K.
    Doxorubicin-induced cell death requires cathepsin B in HeLa cells
    Biochem Pharmacol (2010) 80, 1466-1477. PubMed  Europe PubMed DOI  I
  25. Eykelbosh,A.J. and Van Der Kraak,G.
    A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis
    Comp Biochem Physiol A Mol Integr Physiol (2010) 156, 218-223. PubMed  Europe PubMed DOI  I
  26. Luo,C.L., Chen,X.P., Yang,R., Sun,Y.X., Li,Q.Q., Bao,H.J., Cao,Q.Q., Ni,H., Qin,Z.H. and Tao,L.Y.
    Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway
    J Neurosci Res (2010) 88, 2847-2858. PubMed  Europe PubMed DOI  I
  27. Matarrese,P., Ascione,B., Ciarlo,L., Vona,R., Leonetti,C., Scarsella,M., Mileo,A.M., Catricala',C., Paggi,M.G. and Malorni,W.
    Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study
    Mol Cancer (2010) 9, 207-207. PubMed  Europe PubMed DOI  I
    28. 2009
  28. Yan,B.Z., Wang,W., Chen,L.Y., Bi,M.R., Lu,Y.J., Li,B.X. and Yang,B.S.
    Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice
    World J Gastroenterol (2009) 15, 1231-1236. PubMed  Europe PubMed DOI  PMC  EPMC  I
  29. Yoshii,H., Kamiyama,H., Minematsu,K., Goto,K., Mizota,T., Oishi,K., Katunuma,N., Yamamoto,N. and Kubo,Y.
    Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells
    Virology (2009) 394, 227-234. PubMed  Europe PubMed DOI  I
  30. Zhang,C., Sun,J.B., Liu,D.C., Cui,Y.Q., Liu,S. and Sun,H.C.
    Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice
    Chin Med J (Engl) (2009) 122, 2489-2496. PubMed  Europe PubMed  I
    31. 2008
  31. Hook,V.Y., Kindy,M. and Hook,G.
    Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
    J Biol Chem (2008) 283, 7745-7753. PubMed  Europe PubMed DOI  I
  32. Zhou,G.H., Yu,W.Z. and Li,X.X.
    [The experimental study of specific inhibitor-CA-074Me of cathepsin B suppressing retinal neovascularization]
    Zhonghua Yan Ke Za Zhi (2008) 44, 207-211. PubMed  Europe PubMed  I
    33. 2007
  33. Fujisawa,A., Kambe,N., Saito,M., Nishikomori,R., Tanizaki,H., Kanazawa,N., Adachi,S., Heike,T., Sagara,J., Suda,T., Nakahata,T. and Miyachi,Y.
    Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells
    Blood (2007) 109, 2903-2911. PubMed  Europe PubMed DOI  I
    34. 2003
  34. Gantt,K.R., Schultz-Cherry,S., Rodriguez,N., Jeronimo,S.M., Nascimento,E.T., Goldman,T.L., Recker,T.J., Miller,M.A. and Wilson,M.E.
    Activation of TGF-beta by Leishmania chagasi: importance for parasite survival in macrophages
    J Immunol (2003) 170, 2613-2620. PubMed  Europe PubMed  I
    35. 2002
  35. Jane,D.T., Morvay,L.C., Allen,F., Sloane,B.F. and Dufresne,M.J.
    Selective inhibition of cathepsin B with cell-permeable CA074Me negatively affects L6 rat myoblast differentiation
    Biochem Cell Biol (2002) 80, 457-465. PubMed  Europe PubMed  I
  36. Montaser,M., Lalmanach,G. and Mach,L.
    CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells
    Biol Chem (2002) 383, 1305-1308. PubMed  Europe PubMed DOI  I
  37. [YEAR:11-12-2002]Powers,J.C., Asgian,J.L., Ekici,O.D. and James,K.E.
    Irreversible inhibitors of serine, cysteine, and threonine proteases
    Chem Rev (11-12-2002) 102, 4639-4750. PubMed  Europe PubMed DOI  I
    38. 2001
  38. [YEAR:6-3-2001]Therrien,C., Lachance,P., Sulea,T., Purisima,E.O., Qi,H., Ziomek,E., Alvarez-Hernandez,A., Roush,W.R. and Menard,R.
    Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities
    Biochemistry (6-3-2001) 40, 2702-2711. PubMed  Europe PubMed DOI  I
    39. 2000
  39. Bogyo,M., Verhelst,S., Bellingard-Dubouchaud,V., Toba,S. and Greenbaum,D.
    Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
    Chem Biol (2000) 7, 27-38. PubMed  Europe PubMed DOI  I
  40. Klemencic,I., Carmona,A.K., Cezari,M.H.S., Juliano,M.A., Juliano,L., Guncar,G., Turk,D., Krizaj,I., Turk,V. and Turk,B.
    Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase
    Eur J Biochem (2000) 267, 5404-5412. PubMed  Europe PubMed DOI  I
  41. Yamamoto,A., Tomoo,K., Miyagawa,H., Takaoka,Y., Sumiya,S., Kitamura,K. and Ishida,T.
    Molecular dynamics simulations of bovine cathepsin B and its complex with CA074
    Chem Pharm Bull (Tokyo) (2000) 48, 480-485. PubMed  Europe PubMed  I
  42. Yamamoto,A., Tomoo,K., Hara,T., Murata,M., Kitamura,K. and Ishida,T.
    Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex
    J Biochem (2000) 127, 635-643. PubMed  Europe PubMed  S  I
  43. Zhang,T., Maekawa,Y., Hanba,J., Dainichi,T., Nashed,B.F., Hisaeda,H., Sakai,T., Asao,T., Himeno,K., Good,R.A. and Katunuma,N.
    Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice
    Immunology (2000) 100, 13-20. PubMed  Europe PubMed DOI  PMC  EPMC  I
    44. 1999
  44. Peppard,J.V. and Knap,A.K.
    Effect of the selective and non-selective cysteine protease inhibitors on the intracellular processing of interleukin 6 by HepG2 cells
    In Vitro Cell Dev Biol Anim (1999) 35, 459-464. PubMed  Europe PubMed  I
    45. 1998
  45. [YEAR:3-3-1998]Matsumoto,K., Murata,M., Sumiya,S., Mizoue,K., Kitamura,K. and Ishida,T.
    X-ray crystal structure of papain complexed with cathepsin B-specific covalent-type inhibitor: substrate specificity and inhibitory activity
    Biochim Biophys Acta (3-3-1998) 1383, 93-100. PubMed  Europe PubMed DOI  S  I
  46. Yamashima,T., Kohda,Y., Tsuchiya,K., Ueno,T., Yamashita,J., Yoshioka,T. and Kominami,E.
    Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'
    Eur J Neurosci (1998) 10, 1723-1733. PubMed  Europe PubMed  I
    47. 1997
  47. Yamamoto,A., Hara,T., Tomoo,K., Ishida,T., Fujii,T., Hata,Y., Murata,M. and Kitamura,K.
    Binding mode of CA074, a specific irreversible inhibitor, to bovine cathepsin B as determined by X-ray crystal analysis of the complex
    J Biochem (1997) 121, 974-977. PubMed  Europe PubMed  S  I
  48. Yee,S.T., Okada,Y., Ogasawara,K., Omura,S., Takatsuki,A., Kakiuchi,T., Muno,D., Kominami,E. and Mizuochi,T.
    MHC class I presentation of an exogenous polypeptide antigen encoded by the murine AIDS defective virus
    Microbiol Immunol (1997) 41, 563-570. PubMed  Europe PubMed  I
    49. 1996
  49. Feng,M.H., Chan,S.L., Xiang,Y., Huber,C.P. and Lim,C.
    The binding mode of an E-64 analog to the active site of cathepsin B
    Protein Eng (1996) 9, 977-986. PubMed  Europe PubMed  I
    50. 1995
  50. Turk,D., Podobnik,M., Popovic,T., Katunuma,N., Bode,W., Huber,R. and Turk,V.
    Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: a basis for the design of specific epoxysuccinyl inhibitors
    Biochemistry (1995) 34, 4791-4797. PubMed  Europe PubMed  S  I
  51. Werle,B., Ebert,W., Klein,W. and Spiess,E.
    Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue
    Biol Chem Hoppe Seyler (1995) 376, 157-164. PubMed  Europe PubMed  I
    52. 1992
  52. Buttle,D.J., Murata,M., Knight,C.G. and Barrett,A.J.
    CA074 methyl ester: a proinhibitor for intracellular cathepsin B
    Arch Biochem Biophys (1992) 299, 377-380. PubMed  Europe PubMed DOI  I
  53. Yamamoto,A., Kaji,T., Tomoo,K., Ishida,T., Inoue,M., Murata,M. and Kitamura,K.
    Crystallization and preliminary X-ray study of the cathepsin B complexed with CA074, a selective inhibitor
    J Mol Biol (1992) 227, 942-944. PubMed  Europe PubMed DOI  S  I
    54. 1991
  54. Murata,M., Miyashita,S., Yokoo,C., Tamai,M., Hanada,K., Hatayama,K., Towatari,T., Nikawa,T. and Katunuma,N.
    Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro
    FEBS Lett (1991) 280, 307-310. PubMed  Europe PubMed DOI  I
  55. Towatari,T., Nikawa,T., Murata,M., Yokoo,C., Tamai,M., Hanada,K. and Katunuma,N.
    Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo
    FEBS Lett (1991) 280, 311-315. PubMed  Europe PubMed DOI  I

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