Literature for KYP-2047 (S09.001 inhibitor)

(Topics flags: A Assay, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2020
1. Kilpelainen,T.P., Hellinen,L., Vrijdag,J., Yan,X., Svarcbahs,R., Vellonen,K.S., Lambeir,A.M., Huttunen,H., Urtti,A., Wallen,E.A.A. and Myohanen,T.T.
   The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy
   Biomed Pharmacother128, 110253-110253. PubMed  Europe PubMed DOI  I
2019
2. Natunen,T.A., Gynther,M., Rostalski,H., Jaako,K. and Jalkanen,A.J.
   Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target
   Basic Clin Pharmacol Toxicol124, 40-49. PubMed  Europe PubMed DOI  I
3. Xu,P., Bao,R., Zhang,Y., Lu,E., Feng,F., Zhang,L., Li,J., Wang,J., Tan,X., Tang,M., Hu,C., Li,G. and Zhang,C.
   Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells
   Mol Reprod Dev86, 714-726. PubMed  Europe PubMed DOI  I
2018
4. Fu,P., Sun,W., Lai,J., Shen,Y.H. and Zhang,Z.
   Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: cloning, characterization and expression analysis
   Gene667, 101-111. PubMed  Europe PubMed DOI  I
2016
5. Svarcbahs,R., Julku,U.H. and Myohanen,T.T.
   Inhibition of prolyl oligopeptidase restores spontaneous motor behavior in the alpha-synuclein virus vector-based Parkinson's disease mouse model by decreasing alpha-synuclein oligomeric species in mouse brain
   J Neurosci36, 12485-12497. PubMed  Europe PubMed DOI  I
2015
6. Savolainen,M.H., Yan,X., Myohanen,T.T. and Huttunen,H.J.
   Prolyl oligopeptidase enhances alpha-synuclein dimerization via direct protein-protein interaction
   J Biol Chem290, 5117-5126. PubMed  Europe PubMed DOI  I
2014
7. Dokleja,L., Hannula,M.J. and Myohanen,T.T.
   Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers
   Neurosci Lett583, 37-42. PubMed  Europe PubMed DOI  I
8. Jalkanen,A.J., Leikas,J.V. and Forsberg,M.M.
   KYP-2047 Penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase
   Basic Clin Pharmacol Toxicol114, 460-463. PubMed  Europe PubMed DOI  I
9. Kallinen,A., Todorov,B., Kallionpaa,R., Back,S., Sarparanta,M., Raki,M., Garcia-Horsman,J.A., Bergstrom,K.A., Wallen,E.A., Mannisto,P.T. and Airaksinen,A.J.
   Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-l-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo
   Eur J Med Chem79, 436-445. PubMed  Europe PubMed DOI  L  I
10. Savolainen,M.H., Richie,C.T., Harvey,B.K., Mannisto,P.T., Maguire-Zeiss,K.A. and Myohanen,T.T.
    The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse
    Neurobiol Dis68, 1-15. PubMed  Europe PubMed DOI  I
2012
11. Klimaviciusa,L., Jain,R.K., Jaako,K., Van Elzen,R., Gerard,M., Van der Veken,P., Lambeir,A.M. and Zharkovsky,A.
    In situ prolyl oligopeptidase activity assay in neural cell cultures
    J Neurosci Methods204, 104-110. PubMed  Europe PubMed DOI  A  I
2011
12. Myohanen,T., Tenorio-Laranga,J., Jokinen,B., Vazquez-Sanchez,R., Moreno-Baylach,M., Garcia-Horsman,J. and Mannisto,P.
    Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner
    Br J Pharmacol163, 1666-1678. PubMed  Europe PubMed DOI  I