Literature for ELND007 (XA22.001 inhibitor)

(Topics flags: I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2013
1. Probst,G., Aubele,D.L., Bowers,S., Dressen,D., Garofalo,A.W., Hom,R.K., Konradi,A.W., Marugg,J.L., Mattson,M.N., Neitzel,M.L., Semko,C.M., Sham,H.L., Smith,J., Sun,M., Truong,A.P., Ye,X.M., Xu,Y.Z., Dappen,M.S., Jagodzinski,J.J., Keim,P.S., Peterson,B., Latimer,L.H., Quincy,D., Wu,J., Goldbach,E., Ness,D.K., Quinn,K.P., Sauer,J.M., Wong,K., Zhang,H., Zmolek,W., Brigham,E.F., Kholodenko,D., Hu,K., Kwong,G.T., Lee,M., Liao,A., Motter,R.N., Sacayon,P., Santiago,P., Willits,C., Bard,F., Bova,M.P., Hemphill,S.S., Nguyen,L., Ruslim,L., Tanaka,K., Tanaka,P., Wallace,W., Yednock,T.A. and Basi,G.S.
   Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically stable gamma-secretase inhibitors that selectively inhibit the production of amyloid-beta over notch
   J Med Chem56, 5261-5274. PubMed  Europe PubMed DOI  I