Literature for MRK-560 (A22.001 inhibitor)

(Topics flags: I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2019
1. Habets,R.A., de Bock,C.E., Serneels,L., Lodewijckx,I., Verbeke,D., Nittner,D., Narlawar,R., Demeyer,S., Dooley,J., Liston,A., Taghon,T., Cools,J. and De Strooper,B.
   Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition
   Sci Transl Med11, PubMed  Europe PubMed DOI  I
2011
2. Lee,J., Song,L., Terracina,G., Bara,T., Josien,H., Asberom,T., Sasikumar,T.K., Burnett,D.A., Clader,J., Parker,E.M. and Zhang,L.
   Identification of presenilin 1-selective gamma-secretase inhibitors with reconstituted gamma-secretase complexes
   Biochemistry50, 4973-4980. PubMed  Europe PubMed DOI  I
2007
3. Best,J.D., Smith,D.W., Reilly,M.A., O'Donnell,R., Lewis,H.D., Ellis,S., Wilkie,N., Rosahl,T.W., Laroque,P.A., Boussiquet-Leroux,C., Churcher,I., Atack,J.R., Harrison,T. and Shearman,M.S.
   The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1, 1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse
   J Pharmacol Exp Ther320, 552-558. PubMed  Europe PubMed DOI  I
2006
4. [YEAR:27-1-2006]Best,J.D., Jay,M.T., Otu,F., Churcher,I., Reilly,M., Morentin-Gutierrez,P., Pattison,C., Harrison,T., Shearman,M.S. and Atack,J.R.
   In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1, 1-trifluoromethanesulfonamide (MRK-560) in the rat
   J Pharmacol Exp Ther317, 786-790. PubMed  Europe PubMed DOI  I