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Literature for bestatin (M01.014 inhibitor)

Summary Structure Literature

(Topics flags: A Assay, S Structure, I Inhibitor, E Expression, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Guo,Q., Jing,F.J., Qu,H.J., Xu,W., Han,B., Xing,X.M., Ji,H.Y. and Jing,F.B.<br>Ubenimex reverses MDR in gastric cancer cells by activating caspase-3-mediated apoptosis and suppressing the expression of membrane transport proteins<br>Biomed Res Int (2019) 2019, 4390839-4390839. PubMed  Europe PubMed DOI  PMC  EPMC  I
  2. Liu,H., Wang,X., Yang,H., Zhao,Y., Ji,S., Ma,H., Zhou,Y., Wang,Y., Zhang,H., Jiang,W., Fang,C., Feng,L. and Wang,X.<br>New method for detecting the suppressing effect of enzyme activity by aminopeptidase N inhibitor<br>Chem Pharm Bull (Tokyo) (2019) 67, 155-158. PubMed  Europe PubMed DOI  I
  3. Zhang,H.Y., Xie,Z.P., Lou,T.T. and Wang,S.Y.<br>Complete genome sequence of Streptomyces olivoreticuli ATCC 31159 which can produce anticancer bestatin and show diverse secondary metabolic potentials<br>Curr Microbiol (2019) 76, 370-375. PubMed  Europe PubMed DOI  I
    4. 2018
  4. Shang,S., Willems,A.V. and Chauhan,S.S.<br>A practical diastereoselective synthesis of (-)-bestatin<br>J Pept Sci (2018) 24 PubMed  Europe PubMed DOI  I
  5. Yang,W., Riley,B.T., Lei,X., Porebski,B.T., Kass,I., Buckle,A.M. and McGowan,S.<br>Mapping the pathway and dynamics of bestatin inhibition of the Plasmodium falciparum M1 aminopeptidase PfA-M1<br>ChemMedChem (2018) 13, 2504-2513. PubMed  Europe PubMed DOI  I
    6. 2017
  6. Correa,A.F., Bastos,I.M., Neves,D., Kipnis,A., Junqueira-Kipnis,A.P. and de Santana,J.M.<br>The activity of a hexameric M17 metallo-aminopeptidase is associated with survival of Mycobacterium tuberculosis<br>Front Microbiol (2017) 8, 504-504. PubMed  Europe PubMed DOI  PMC  EPMC  I
    7. 2016
  7. Hossain,A., Heron,D., Davenport,I., Huckaba,T., Graves,R., Mandal,T., Muniruzzaman,S., Wang,S. and Bhattacharjee,P.S.<br>Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice<br>Exp Eye Res (2016) 149, 100-106. PubMed  Europe PubMed DOI  I
  8. Zhang,Y., Feng,J., Cui,L., Zhang,Y., Li,W., Li,C., Shi,N., Chen,Y. and Kong,W.<br>Investigation into efficiency of a novel glycol chitosan-bestatin conjugate to protect thymopoietin oligopeptides from enzymatic degradation<br>J Pharm Sci (2016) 105, 828-837. PubMed  Europe PubMed DOI  I
    9. 2015
  9. Aboge,G.O., Cao,S., Terkawi,M.A., Masatani,T., Goo,Y., AbouLaila,M., Nishikawa,Y., Igarashi,I., Suzuki,H. and Xuan,X.<br>Molecular characterization of Babesia bovis M17 leucine aminopeptidase and inhibition of Babesia growth by bestatin<br>J Parasitol (2015) 101, 536-541. PubMed  Europe PubMed DOI  I
  10. Chen,H., Wang,H., Qin,X.-J., Chen,C., Feng,L., Chen,L.-Z., Du,L.-P. and Li,M.-Y.<br>A bestatin-based fluorescent probe for aminopeptidase N cell imaging<br>Chin Chem Lett (2015) 26, 513-516. DOI  L  I
  11. Li,J., Wang,X., Hou,J., Huang,Y., Zhang,Y. and Xu,W.<br>Enhanced anticancer activity of 5-FU in combination with bestatin: evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse<br>Drug Discov Ther (2015) 9, 45-52. PubMed  Europe PubMed DOI  I
  12. Seo,Y., Lee,S.B. and Kim,Y.G.<br>Stereoselective synthesis of novel bestatin analogs<br>Appl Chem Eng (2015) 26, 111-115. DOI  I
  13. Trochine,A., Creek,D.J., Faral-Tello,P., Barrett,M.P. and Robello,C.<br>Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool<br>Antimicrob Agents Chemother (2015) 59, 2921-2925. PubMed  Europe PubMed DOI  I
  14. Tykvart,J., Barinka,C., Svoboda,M., Navratil,V., Soucek,R., Hubalek,M., Hradilek,M., Sacha,P., Lubkowski,J. and Konvalinka,J.<br>Structural and biochemical characterization of a novel aminopeptidase from human intestine<br>J Biol Chem (2015) 290, 11321-11336. PubMed  Europe PubMed DOI  E  S  I
  15. Wang,X., Shi,L., Deng,Y., Qu,M., Mao,S., Xu,L., Xu,W. and Fang,C.<br>Inhibition of leucine aminopeptidase 3 suppresses invasion of ovarian cancer cells through down-regulation of fascin and MMP-2/9<br>Eur J Pharmacol (2015) 768, 116-122. PubMed  Europe PubMed DOI  I
    16. 2014
  16. Hitzerd,S.M., Verbrugge,S.E., Ossenkoppele,G., Jansen,G. and Peters,G.J.<br>Positioning of aminopeptidase inhibitors in next generation cancer therapy<br>Amino Acids (2014) 46, 793-808. PubMed  Europe PubMed DOI  I
    17. 2013
  17. Lis,M. and Obminska-Mrukowicz,B.<br>Modulatory effects of bestatin on T and B lymphocyte subsets and the concentration of cytokines released by Th1/Th2 lymphocytes in cyclophosphamide-treated mice<br>Cent -Eur J Immunol (2013) 38, 42-53. DOI  I
  18. Modak,J.K. and Roujeinikova,A.<br>Cloning, purification and preliminary crystallographic analysis of the Helicobacter pylori leucyl aminopeptidase-bestatin complex<br>Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 69, 1011-1014. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    19. 2012
  19. Ascher,D.B., Polekhina,G. and Parker,M.W.<br>Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2<br>Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 68, 468-471. PubMed  Europe PubMed DOI  PMC  EPMC  I
  20. Poloz,Y., Catalano,A. and O'Day,D.H.<br>Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum<br>Eukaryot Cell (2012) 11, 545-557. PubMed  Europe PubMed DOI  I
  21. Schreiter,A., Gore,C., Labuz,D., Fournie-Zaluski,M.C., Roques,B.P., Stein,C. and Machelska,H.<br>Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue<br>FASEB J (2012) 26, 5161-5171. PubMed  Europe PubMed DOI  I
  22. Su,L., Jia,Y., Zhang,L., Xu,Y., Fang,H. and Xu,W.<br>Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors<br>Bioorg Med Chem (2012) 20, 3807-3815. PubMed  Europe PubMed DOI  I
  23. Wong,A.H., Zhou,D. and Rini,J.M.<br>The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing<br>J Biol Chem (2012) 287, 36804-36813. PubMed  Europe PubMed DOI  S  I
  24. Zhu,Y., Meng,Q., Wang,C., Liu,Q., Sun,H., Kaku,T. and Liu,K.<br>Organic anion transporters involved in the excretion of bestatin in the kidney<br>Peptides (2012) 33, 265-271. PubMed  Europe PubMed DOI  I
    25. 2011
  25. Chen,L., Teng,Y. and Xu,W.<br>Progress in the development of bestatin analogues as aminopeptidases inhibitors<br>Curr Med Chem (2011) 18, 964-976. PubMed  Europe PubMed DOI  V  I
  26. Gao,J.J., Gao,Z.H., Zhao,C.R., Yuan,Y., Cui,S.X., Zhang,X.F., Cheng,Y.N., Xu,W.F., Tang,W. and Qu,X.J.<br>LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin<br>Invest New Drugs (2011) 29, 574-582. PubMed  Europe PubMed DOI  I
  27. Lis,M., Szczypka,M., Suszko,A. and Obminska-Mrukowicz,B.<br>Influence of bestatin, an inhibitor of aminopeptidases, on T and B lymphocyte subsets in mice<br>Pol J Vet Sci (2011) 14, 393-403. PubMed  Europe PubMed DOI  I
  28. Lis,M. and Obminska-Mrukowicz,B.<br>Effects of bestatin on phagocytic cells in cyclophosphamide-treated mice<br>Pharmacol Rep (2011) 63, 1481-1490. PubMed  Europe PubMed  I
  29. Luan,Y., Ma,C., Sui,Z., Wang,X., Feng,J., Liu,N., Jing,F., Wang,Y., Li,M., Fang,H. and Xu,W.<br>LYP3, a new bestatin derivative for aminopeptidase N inhibition<br>Med Chem (2011) 7, 32-36. PubMed  Europe PubMed  I
  30. Luan,Y., Wang,Q., Liu,N., Mou,J., Jiao,X., Fang,H., Li,M. and Xu,W.<br>Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor<br>Anticancer Drugs (2011) 22, 99-103. PubMed  Europe PubMed DOI  I
  31. Velmourougane,G., Harbut,M.B., Dalal,S., McGowan,S., Oellig,C.A., Meinhardt,N., Whisstock,J.C., Klemba,M. and Greenbaum,D.C.<br>Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase<br>J Med Chem (2011) 54, 1655-1666. PubMed  Europe PubMed DOI  I
    32. 2010
  32. Jia,M.R., Wei,T. and Xu,W.F.<br>The analgesic activity of bestatin as a potent APN inhibitor<br>Front Neurosci (2010) 4, 50-50. PubMed  Europe PubMed DOI  PMC  EPMC  I
    33. 2009
  33. Luan,Y., Wang,X., Zhu,H., Qu,X., Fang,H. and Xu,W.<br>The synthesis and activity evaluation of a bestatin derivative (LYP) as an aminopeptidase N inhibitor<br>Lett Drug Des Discov (2009) 6, 420-423. DOI  I
    34. 2008
  34. George,S., Suryavanshi,G.S. and Sudalai,A.<br>A short enantioselective synthesis of (-)-bestatin via l-proline-catalyzed alpha-amination of an aldehyde<br>Tetrahedron Lett (2008) 49, 6791-6793. DOI  I
  35. Harbut,M.B., Velmourougane,G., Reiss,G., Chandramohanadas,R. and Greenbaum,D.C.<br>Development of bestatin-based activity-based probes for metallo-aminopeptidases<br>Bioorg Med Chem Lett (2008) 18, 5932-5936. PubMed  Europe PubMed DOI  PMC  EPMC  I
  36. Luan,Y., Mu,J. and Xu,W.<br>The review of the synthesis of bestatin, an effective inhibitor of aminopeptidase N<br>Mini-Rev Org Chem (2008) 5, 134-140. DOI  V  I
    37. 2007
  37. Feske,B.D.<br>Bestatin: three decades of synthetic strategies<br>Curr Org Chem (2007) 11, 483-496. DOI  I
  38. Wang,C., Fan,G., Lin,M., Chen,Y., Zhao,W. and Wu,Y.<br>Development of a liquid chromatography/tandem mass spectrometry assay for the determination of bestatin in rat plasma and its application to a pharmacokinetic study<br>J Chromatogr B Analyt Technol Biomed Life Sci (2007) 850, 101-108. PubMed  Europe PubMed DOI  A  I
    39. 2006
  39. Addlagatta,A., Gay,L. and Matthews,B.W.<br>Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site<br>Proc Natl Acad Sci U S A (2006) 103, 13339-13344. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  40. [YEAR:23-6-2006]Zheng,W., Zhai,Q., Sun,J., Li,C.B., Zhang,L., Li,H., Zhang,X., Li,S., Xu,Y., Jiang,H., Wu,X. and Li,C.<br>Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in Arabidopsis<br>Plant Physiol (23-6-2006) 141, 1400-1413. PubMed  Europe PubMed DOI  PMC  EPMC  I
    41. 2005
  41. [YEAR:15-8-2005]Stockel-Maschek,A., Stiebitz,B., Koelsch,R. and Neubert,K.<br>Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: synthesis and kinetic characterization as aminopeptidase P inhibitors<br>Bioorg Med Chem (15-8-2005) 13, 4806-4820. PubMed  Europe PubMed DOI  I
    42. 2004
  42. [YEAR:8-12-2004]Aozuka,Y., Koizumi,K., Saitoh,Y., Ueda,Y., Sakurai,H. and Saiki,I.<br>Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice<br>Cancer Lett (8-12-2004) 216, 35-42. PubMed  Europe PubMed DOI  I
  43. Chen,X., Wang,S., Wu,N. and Yang,C.S.<br>Leukotriene A4 hydrolase as a target for cancer prevention and therapy<br>Curr Cancer Drug Targets (2004) 4, 267-283. PubMed  Europe PubMed DOI  I
  44. [YEAR:3-8-2004]Stamper,C.C., Bienvenue,D.L., Bennett,B., Ringe,D., Petsko,G.A. and Holz,R.C.<br>Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica<br>Biochemistry (3-8-2004) 43, 9620-9628. PubMed  Europe PubMed DOI  S  I
    45. 2003
  45. [YEAR:16-4-2003]Ichinose,Y., Genka,K., Koike,T., Kato,H., Watanabe,Y., Mori,T., Iioka,S., Sakuma,A. and Ohta,M.<br>Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma<br>J Natl Cancer Inst (16-4-2003) 95, 605-610. PubMed  Europe PubMed  I
    46. 2002
  46. Chandra,D., Ramana,K.V., Wang,L., Christensen,B.N., Bhatnagar,A. and Srivastava,S.K.<br>Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin<br>Invest Ophthalmol Vis Sci (2002) 43, 2285-2292. PubMed  Europe PubMed  I
    47. 2001
  47. Thunnissen,M.M., Nordlund,P. and Haeggstrom,J.Z.<br>Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation<br>Nat Struct Biol (2001) 8, 131-135. PubMed  Europe PubMed DOI  S  I
    48. 2000
  48. [YEAR:1-2-2000]Andberg,M., Wetterholm,A., Medina,J.F. and Haeggstrom,J.Z.<br>Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin<br>Biochem J (1-2-2000) 345, 621-625. PubMed  Europe PubMed DOI  PMC  EPMC  I
  49. Imamura,N. and Kimura,A.<br>Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: Up-and down-regulation of CD13/aminopeptidase N<br>Leuk Lymphoma (2000) 37, 663-667. PubMed  Europe PubMed DOI  I
    50. 1999
  50. [YEAR:16-4-1999]Bergmeier,S.C. and Stanchina,D.M.<br>Acylnitrene route to vicinal amino alcohols. Application to the synthesis of (-)-bestatin and analogues<br>J Org Chem (16-4-1999) 64, 2852-2859. PubMed  Europe PubMed  I
    51. 1998
  51. Nankya-Kitaka,M.F., Curley,G.P., Gavigan,C.S., Bell,A. and Dalton,J.P.<br>Plasmodium chabaudi chabaudi and P. falciparum: inhibition of aminopeptidase and parasite growth by bestatin and nitrobestatin<br>Parasitol Res (1998) 84, 552-558. PubMed  Europe PubMed DOI  I
    52. 1996
  52. Chung,M.C., Lee,H.J., Chun,H.K., Lee,C.H., Kim,S.I. and Kho,Y.H.<br>Bestatin analogue from Streptomyces neyagawaensis SL-387<br>Biosci Biotechnol Biochem (1996) 60, 898-900. PubMed  Europe PubMed  I
  53. Ezawa,K., Minato,K. and Dobashi,K.<br>Induction of apoptosis by ubenimex (Bestatin) in human non-small-cell lung cancer cell lines<br>Biomed Pharmacother (1996) 50, 283-289. PubMed  Europe PubMed DOI  I
  54. Koseki,K., Ebata,T. and Matsushita,H.<br>Synthesis of bestatin, a potent inhibitor of leukotriene A4 hydrolase, by an N3 nucleophile reaction to a non-protected diol<br>Biosci Biotechnol Biochem (1996) 60, 534-536. PubMed  Europe PubMed  I
    55. 1993
  55. [YEAR:5-4-1993]Kim,H., Burley,S.K. and Lipscomb,W.N.<br>Re-refinement of the X-ray crystal structure of bovine lens leucine aminopeptidase complexed with bestatin<br>J Mol Biol (5-4-1993) 230, 722-724. PubMed  Europe PubMed DOI  S  I
  56. Taylor,A., Peltier,C.Z., Torre,F.J. and Hakamian,N.<br>Inhibition of bovine lens leucine aminopeptidase by bestatin: number of binding sites and slow binding of this inhibitor<br>Biochemistry (1993) 32, 784-790. PubMed  Europe PubMed DOI  I
    57. 1992
  57. Burley,S.K., David,P.R., Sweet,R.M., Taylor,A. and Lipscomb,W.N.<br>Structure determination and refinement of bovine lens leucine aminopeptidase and its complex with bestatin<br>J Mol Biol (1992) 224, 113-140. PubMed  Europe PubMed DOI  S  I
  58. Taylor,A., Peltier,C.Z., Jahngen,E.G., Jr., Laxman,E., Szewczuk,Z. and Torre,F.J.<br>Use of azidobestatin as a photoaffinity label to identify the active site peptide of leucine aminopeptidase<br>Biochemistry (1992) 31, 4141-4150. PubMed  Europe PubMed DOI  I
    59. 1991
  59. Burley,S.K., David,P.R. and Lipscomb,W.N.<br>Leucine aminopeptidase: bestatin inhibition and a model for enzyme-catalyzed peptide hydrolysis<br>Proc Natl Acad Sci U S A (1991) 88, 6916-6920. PubMed  Europe PubMed  PMC  EPMC  S  I
  60. [YEAR:25-1-1991]Orning,L., Krivi,G. and Fitzpatrick,F.A.<br>Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes<br>J Biol Chem (25-1-1991) 266, 1375-1378. PubMed  Europe PubMed  I
    61. 1989
  61. Saiki,I., Murata,J., Watanabe,K., Fujii,H., Abe,F. and Azuma,I.<br>Inhibition of tumor cell invasion by ubenimex (bestatin) in vitro<br>Jpn J Cancer Res (1989) 80, 873-878. PubMed  Europe PubMed  I
    62. 1988
  62. Harbeson,S.L. and Rich,D.H.<br>Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases<br>Biochemistry (1988) 27, 7301-7310. PubMed  Europe PubMed  I
  63. Ocain,T.D. and Rich,D.H.<br>Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues<br>J Med Chem (1988) 31, 2193-2199. PubMed  Europe PubMed  I
  64. Peppers,S.C. and Lenney,J.F.<br>Bestatin inhibition of human tissue carnosinase, a non-specific cytosolic dipeptidase<br>Biol Chem Hoppe Seyler (1988) 369, 1281-1286. PubMed  Europe PubMed  I
    65. 1986
  65. Powers,J.C. and Harper,J.W.<br>Inhibitors of metalloproteases<br> (1986) , 219-298.  V  I
    66. 1985
  66. [YEAR:25-10-1985]Wilkes,S.H. and Prescott,J.M.<br>The slow, tight binding of bestatin and amastatin to aminopeptidases<br>J Biol Chem (25-10-1985) 260, 13154-13162. PubMed  Europe PubMed  I
    67. 1984
  67. Rich,D.H., Moon,B.J. and Harbeson,S.<br>Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes<br>J Med Chem (1984) 27, 417-422. PubMed  Europe PubMed  I
  68. Rohm,K.H.<br>Interaction of the (2S,3S)-isomer of bestatin with yeast aminopeptidase I. Kinetic and binding studies<br>Hoppe Seylers Z Physiol Chem (1984) 365, 1235-1246. PubMed  Europe PubMed  I
    69. 1983
  69. Blomgren,H.<br>Bestatin, a new immunomodulator<br>Clin Immunol Newsl (1983) 4, 15-18.  I
  70. Nishizawa,R., Saino,T., Suzuki,M., Fujii,T., Shirai,T., Aoyagi,T. and Umezawa,H.<br>A facile synthesis of bestatin<br>J Antibiot (Tokyo) (1983) 36, 695-699. PubMed  Europe PubMed  I
    71. 1982
  71. Ricci,J.S., Jr., Bousvaros,A. and Taylor,A.<br>Crystal and molecular structure of bestatin and its implications regarding substrate binding to the active site of leucine aminopeptidase<br>J Org Chem (1982) 47, 3063-3065.  I
    72. 1976
  72. Suda,H., Aoyagi,T., Takeuchi,T. and Umezawa,H.<br>Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer<br>Arch Biochem Biophys (1976) 177, 196-200. PubMed  Europe PubMed  I
  73. Suda,H., Takita,T., Aoyagi,T. and Umezawa,H.<br>The structure of bestatin<br>J Antibiot (Tokyo) (1976) 29, 100-101. PubMed  Europe PubMed  I
  74. Umezawa,H., Aoyagi,T., Suda,H., Hamada,M. and Takeuchi,T.<br>Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes<br>J Antibiot (Tokyo) (1976) 29, 97-99. PubMed  Europe PubMed  I

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