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Literature for inhibitor I42.001: chagasin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: S Structure, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Cardenas-Guerra,R.E., Montes-Flores,O., Nava-Pintor,E.E., Resendiz-Cardiel,G., Flores-Pucheta,C.I., Rodriguez-Gavaldon,Y.I., Arroyo,R., Bottazzi,M.E., Hotez,P.J. and Ortega-Lopez,J.
    Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras
    Protein Expr Purif (2024) 218, 106458-106458. PubMed  Europe PubMed DOI
    2. 2020
  2. Cerny,N., Bivona,A.E., Sanchez Alberti,A., Trinitario,S.N., Morales,C., Cardoso Landaburu,A., Cazorla,S.I. and Malchiodi,E.L.
    Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi
    Front Immunol (2020) 11, 565142-565142. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Toman,N.P., Kamenik,A.S., Santos,L.H., Hofer,F., Liedl,K.R. and Ferreira,R.S.
    Profiling selectivity of chagasin mutants towards cysteine proteases cruzain or cathepsin L through molecular dynamics simulations
    J Biomol Struct Dyn (2020) , 1-13. PubMed  Europe PubMed DOI
    4. 2019
  4. Reyes-Espinosa,F., Juarez-Saldivar,A., Palos,I., Herrera-Mayorga,V., Garcia-Perez,C. and Rivera,G.
    In silico analysis of homologous heterodimers of cruzipain-chagasin from structural models built by homology
    Int J Mol Sci (2019) 20 PubMed  Europe PubMed DOI
    5. 2016
  5. Costa,T.F. and Lima,A.P.
    Natural cysteine protease inhibitors in protozoa: fifteen years of the chagasin family
    Biochimie (2016) 122, 197-207. PubMed  Europe PubMed DOI
    6. 2014
  6. Alsford,S., Currier,R.B., Guerra-Assuncao,J.A., Clark,T.G. and Horn,D.
    Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei
    PLoS Pathog (2014) 10, e1004130-e1004130. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2012
  7. Oliveira Neto,O.B., Farias,D.F., Vasconcelos,I.M., Paes,N.S., Monteiro,A.C., Silva,M.C., Guimaraes,L.M., Carvalho,A.F. and Grossi-de-Sa,M.F.
    A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein
    An Acad Bras Cienc (2012) 84, 185-190. PubMed  Europe PubMed DOI
    8. 2011
  8. Hansen,G., Schwarzloh,B., Rennenberg,A., Heussler,V.T. and Hilgenfeld,R.
    The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis
    Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 67, 1406-1410. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2010
  9. Lima,A.P.C.A. and Mottram,J.C.
    Trypanosomatid-encoded inhibitors of peptidases: unique structural features and possible roles as virulence factors
    Open Parasitol J (2010) 4, 132-138. DOI
    10. 2009
  10. Bryson,K., Besteiro,S., McGachy,H.A., Coombs,G.H., Mottram,J.C. and Alexander,J.
    Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response
    Infect Immun (2009) 77, 2971-2978. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Jecna,L., Svarovska,A., Besteiro,S., Mottram,J.C., Coombs,G.H. and Volf,P.
    Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis
    J Med Entomol (2009) 46, 605-609. PubMed  Europe PubMed DOI
  12. Redzynia,I., Ljunggren,A., Bujacz,A., Abrahamson,M., Jaskolski,M. and Bujacz,G.
    Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases
    FEBS J (2009) 276, 793-806. PubMed  Europe PubMed DOI  S
    13. 2008
  13. dos Reis,F.C., Smith,B.O., Santos,C.C., Costa,T.F., Scharfstein,J., Coombs,G.H., Mottram,J.C. and Lima,A.P.
    The role of conserved residues of chagasin in the inhibition of cysteine peptidases
    FEBS Lett (2008) 582, 485-490. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Dos Santos Monteiro,A.C., de Oliveira Neto,O.B., Del Sarto,R.P., de Magalhaes,M.T., Lima,J.N., Lacerda,A.F., Oliveira,R.S., Scharfstein,J., da Silva,M.C., Valencia,J.W., Jimenez,A.V. and Grossi-de-Sa,M.F.
    A recombinant form of chagasin from Trypanosoma cruzi: inhibitory activity on insect cysteine proteinases
    Pest Manag Sci (2008) 64, 755-760. PubMed  Europe PubMed DOI
  15. Redzynia,I., Ljunggren,A., Abrahamson,M., Mort,J.S., Krupa,J.C., Jaskolski,M. and Bujacz,G.
    Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B
    J Biol Chem (2008) 283, 22815-22825. PubMed  Europe PubMed DOI
  16. Scharfstein,J. and Lima,A.P.
    Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi
    Subcell Biochem (2008) 47, 140-154. PubMed  Europe PubMed DOI
    17. 2007
  17. Figueiredo da Silva,A.A., de Carvalho Vieira,L., Krieger,M.A., Goldenberg,S., Zanchin,N.I. and Guimaraes,B.G.
    Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi
    J Struct Biol (2007) 157, 416-423. PubMed  Europe PubMed DOI  S
  18. Ljunggren,A., Redzynia,I., Alvarez-Fernandez,M., Abrahamson,M., Mort,J.S., Krupa,J.C., Jaskolski,M. and Bujacz,G.
    Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease
    J Mol Biol (2007) 371, 137-153. PubMed  Europe PubMed DOI  S
  19. Santos,C.C., Coombs,G.H., Lima,A.P. and Mottram,J.C.
    Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence
    Mol Microbiol (2007) 66, 991-1002. PubMed  Europe PubMed DOI  PMC  EPMC  K
  20. Wang,S.X., Pandey,K.C., Scharfstein,J., Whisstock,J., Huang,R.K., Jacobelli,J., Fletterick,R.J., Rosenthal,P.J., Abrahamson,M., Brinen,L.S., Rossi,A., Sali,A. and McKerrow,J.H.
    The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family
    Structure (2007) 15, 535-543. PubMed  Europe PubMed DOI  S
    21. 2006
  21. Aido-Machado,R., Salmon,D., Diehl,A., Leidert,M., Schmetzer,O., de Lima,A.P., Scharfstein,J., Oschkinat,H. and Pires,J.R.
    1H, 15N and 13C assignments of the cysteine protease inhibitor chagasin from Trypanosoma cruzi
    J Biomol NMR (2006) 36 Suppl 1, 30-30. PubMed  Europe PubMed DOI  S
  22. [YEAR:1-6-2006]Alphey,M.S. and Hunter,W.N.
    High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei
    Acta Crystallograph Sect F Struct Biol Cryst Commun (1-6-2006) 62, 504-508. PubMed  Europe PubMed DOI  PMC  EPMC  S
  23. [YEAR:3-2-2006]Salmon,D., do Aido-Machado,R., Diehl,A., Leidert,M., Schmetzer,O., de,A.L., Scharfstein,J., Oschkinat,H. and Pires,J.R.
    Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin
    J Mol Biol (3-2-2006) 357, 1511-1521. PubMed  Europe PubMed DOI  S
  24. [YEAR:28-12-2006]Smith,B.O., Picken,N.C., Westrop,G.D., Bromek,K., Mottram,J.C. and Coombs,G.H.
    The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors
    J Biol Chem (28-12-2006) 281, 5821-5828. PubMed  Europe PubMed DOI  PMC  EPMC  S
  25. Smith,B.O., Westrop,G.D., Mottram,J.C. and Coombs,G.H.
    Chemical shift assignments of Leishmania mexicana ICP, a novel cysteine peptidase inhibitor
    J Biomol NMR (2006) 36 Suppl 1, 7-7. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2005
  26. [YEAR:1-3-2005]Santos,C.C., Sant'Anna,C., Terres,A., Cunha-e-Silva, Scharfstein,J. and de,A.L.
    Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells
    J Cell Sci (1-3-2005) 118, 901-915. PubMed  Europe PubMed DOI
    27. 2004
  27. Besteiro,S., Coombs,G.H. and Mottram,J.C.
    A potential role for ICP, a leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite
    Mol Microbiol (2004) 54, 1224-1236. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2003
  28. [YEAR:8-5-2003]Sanderson,S.J., Westrop,G.D., Scharfstein,J., Mottram,J.C. and Coombs,G.H.
    Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens
    FEBS Lett (8-5-2003) 542, 12-16. PubMed  Europe PubMed DOI
    29. 2002
  29. Rigden,D.J., Mosolov,V.V. and Galperin,M.Y.
    Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors
    Protein Sci (2002) 11, 1971-1977. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2001
  30. Monteiro,A.C., Abrahamson,M., Lima,A.P., Vannier-Santos,M.A. and Scharfstein,J.
    Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi
    J Cell Sci (2001) 114, 3933-3942. PubMed  Europe PubMed
  31. [YEAR:24-8-2001]Rigden,D.J., Monteiro,A.C. and Grossi de Sa,M.F.
    The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer
    FEBS Lett (24-8-2001) 504, 41-44. PubMed  Europe PubMed DOI

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