Literature for inhibitor I42.001: chagasin

(Topics flags: S Structure, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

2024
1. Cardenas-Guerra,R.E., Montes-Flores,O., Nava-Pintor,E.E., Resendiz-Cardiel,G., Flores-Pucheta,C.I., Rodriguez-Gavaldon,Y.I., Arroyo,R., Bottazzi,M.E., Hotez,P.J. and Ortega-Lopez,J.
   Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras
   Protein Expr Purif218, 106458-106458. PubMed  Europe PubMed DOI
2020
2. Cerny,N., Bivona,A.E., Sanchez Alberti,A., Trinitario,S.N., Morales,C., Cardoso Landaburu,A., Cazorla,S.I. and Malchiodi,E.L.
   Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi
   Front Immunol11, 565142-565142. PubMed  Europe PubMed DOI
3. Toman,N.P., Kamenik,A.S., Santos,L.H., Hofer,F., Liedl,K.R. and Ferreira,R.S.
   Profiling selectivity of chagasin mutants towards cysteine proteases cruzain or cathepsin L through molecular dynamics simulations
   J Biomol Struct Dyn1-13. PubMed  Europe PubMed DOI
2019
4. Reyes-Espinosa,F., Juarez-Saldivar,A., Palos,I., Herrera-Mayorga,V., Garcia-Perez,C. and Rivera,G.
   In silico analysis of homologous heterodimers of cruzipain-chagasin from structural models built by homology
   Int J Mol Sci20, PubMed  Europe PubMed DOI
2016
5. Costa,T.F. and Lima,A.P.
   Natural cysteine protease inhibitors in protozoa: fifteen years of the chagasin family
   Biochimie122, 197-207. PubMed  Europe PubMed DOI
2014
6. Alsford,S., Currier,R.B., Guerra-Assuncao,J.A., Clark,T.G. and Horn,D.
   Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei
   PLoS Pathog10, e1004130-e1004130. PubMed  Europe PubMed DOI
2012
7. Oliveira Neto,O.B., Farias,D.F., Vasconcelos,I.M., Paes,N.S., Monteiro,A.C., Silva,M.C., Guimaraes,L.M., Carvalho,A.F. and Grossi-de-Sa,M.F.
   A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein
   An Acad Bras Cienc84, 185-190. PubMed  Europe PubMed DOI
2011
8. Hansen,G., Schwarzloh,B., Rennenberg,A., Heussler,V.T. and Hilgenfeld,R.
   The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis
   Acta Crystallogr Sect F Struct Biol Cryst Commun67, 1406-1410. PubMed  Europe PubMed DOI
2010
9. Lima,A.P.C.A. and Mottram,J.C.
   Trypanosomatid-encoded inhibitors of peptidases: unique structural features and possible roles as virulence factors
   Open Parasitol J4, 132-138. DOI
2009
10. Bryson,K., Besteiro,S., McGachy,H.A., Coombs,G.H., Mottram,J.C. and Alexander,J.
    Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response
    Infect Immun77, 2971-2978. PubMed  Europe PubMed DOI
11. Jecna,L., Svarovska,A., Besteiro,S., Mottram,J.C., Coombs,G.H. and Volf,P.
    Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis
    J Med Entomol46, 605-609. PubMed  Europe PubMed DOI
12. Redzynia,I., Ljunggren,A., Bujacz,A., Abrahamson,M., Jaskolski,M. and Bujacz,G.
    Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases
    FEBS J276, 793-806. PubMed  Europe PubMed DOI  S
2008
13. dos Reis,F.C., Smith,B.O., Santos,C.C., Costa,T.F., Scharfstein,J., Coombs,G.H., Mottram,J.C. and Lima,A.P.
    The role of conserved residues of chagasin in the inhibition of cysteine peptidases
    FEBS Lett582, 485-490. PubMed  Europe PubMed DOI
14. Dos Santos Monteiro,A.C., de Oliveira Neto,O.B., Del Sarto,R.P., de Magalhaes,M.T., Lima,J.N., Lacerda,A.F., Oliveira,R.S., Scharfstein,J., da Silva,M.C., Valencia,J.W., Jimenez,A.V. and Grossi-de-Sa,M.F.
    A recombinant form of chagasin from Trypanosoma cruzi: inhibitory activity on insect cysteine proteinases
    Pest Manag Sci64, 755-760. PubMed  Europe PubMed DOI
15. Redzynia,I., Ljunggren,A., Abrahamson,M., Mort,J.S., Krupa,J.C., Jaskolski,M. and Bujacz,G.
    Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B
    J Biol Chem283, 22815-22825. PubMed  Europe PubMed DOI
16. Scharfstein,J. and Lima,A.P.
    Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi
    Subcell Biochem47, 140-154. PubMed  Europe PubMed DOI
2007
17. Figueiredo da Silva,A.A., de Carvalho Vieira,L., Krieger,M.A., Goldenberg,S., Zanchin,N.I. and Guimaraes,B.G.
    Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi
    J Struct Biol157, 416-423. PubMed  Europe PubMed DOI  S
18. Ljunggren,A., Redzynia,I., Alvarez-Fernandez,M., Abrahamson,M., Mort,J.S., Krupa,J.C., Jaskolski,M. and Bujacz,G.
    Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease
    J Mol Biol371, 137-153. PubMed  Europe PubMed DOI  S
19. Santos,C.C., Coombs,G.H., Lima,A.P. and Mottram,J.C.
    Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence
    Mol Microbiol66, 991-1002. PubMed  Europe PubMed DOI  K
20. Wang,S.X., Pandey,K.C., Scharfstein,J., Whisstock,J., Huang,R.K., Jacobelli,J., Fletterick,R.J., Rosenthal,P.J., Abrahamson,M., Brinen,L.S., Rossi,A., Sali,A. and McKerrow,J.H.
    The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family
    Structure15, 535-543. PubMed  Europe PubMed DOI  S
2006
21. Aido-Machado,R., Salmon,D., Diehl,A., Leidert,M., Schmetzer,O., de Lima,A.P., Scharfstein,J., Oschkinat,H. and Pires,J.R.
    1H, 15N and 13C assignments of the cysteine protease inhibitor chagasin from Trypanosoma cruzi
    J Biomol NMR36 Suppl 1, 30-30. PubMed  Europe PubMed DOI  S
22. [YEAR:1-6-2006]Alphey,M.S. and Hunter,W.N.
    High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei
    Acta Crystallograph Sect F Struct Biol Cryst Commun62, 504-508. PubMed  Europe PubMed DOI  S
23. [YEAR:3-2-2006]Salmon,D., do Aido-Machado,R., Diehl,A., Leidert,M., Schmetzer,O., de,A.L., Scharfstein,J., Oschkinat,H. and Pires,J.R.
    Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin
    J Mol Biol357, 1511-1521. PubMed  Europe PubMed DOI  S
24. Smith,B.O., Westrop,G.D., Mottram,J.C. and Coombs,G.H.
    Chemical shift assignments of Leishmania mexicana ICP, a novel cysteine peptidase inhibitor
    J Biomol NMR36 Suppl 1, 7-7. PubMed  Europe PubMed DOI
25. [YEAR:28-12-2006]Smith,B.O., Picken,N.C., Westrop,G.D., Bromek,K., Mottram,J.C. and Coombs,G.H.
    The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors
    J Biol Chem281, 5821-5828. PubMed  Europe PubMed DOI  S
2005
26. [YEAR:1-3-2005]Santos,C.C., Sant'Anna,C., Terres,A., Cunha-e-Silva, Scharfstein,J. and de,A.L.
    Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells
    J Cell Sci118, 901-915. PubMed  Europe PubMed DOI
2004
27. Besteiro,S., Coombs,G.H. and Mottram,J.C.
    A potential role for ICP, a leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite
    Mol Microbiol54, 1224-1236. PubMed  Europe PubMed DOI
2003
28. [YEAR:8-5-2003]Sanderson,S.J., Westrop,G.D., Scharfstein,J., Mottram,J.C. and Coombs,G.H.
    Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens
    FEBS Lett542, 12-16. PubMed  Europe PubMed DOI
2002
29. Rigden,D.J., Mosolov,V.V. and Galperin,M.Y.
    Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors
    Protein Sci11, 1971-1977. PubMed  Europe PubMed DOI
2001
30. Monteiro,A.C., Abrahamson,M., Lima,A.P., Vannier-Santos,M.A. and Scharfstein,J.
    Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi
    J Cell Sci114, 3933-3942. PubMed  Europe PubMed
31. [YEAR:24-8-2001]Rigden,D.J., Monteiro,A.C. and Grossi de Sa,M.F.
    The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer
    FEBS Lett504, 41-44. PubMed  Europe PubMed DOI