Merops Switch to
Peptidases

Inhibitor

Family Clan Small-molecule
inhibitor SEARCHES BLAST
MEROPS

Other
information

Literature for inhibitor I35.003: timp-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits Pharma

(Topics flags: S Structure, T Target, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Betts,J.H.J. and Troeberg,L.
    Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy
    Mol Vis (2024) 30, 74-91. PubMed  Europe PubMed  PMC  EPMC  V
  2. Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E.
    Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target
    Basic Clin Pharmacol Toxicol (2024) 134, 727-736. PubMed  Europe PubMed DOI  L
  3. Lee,W.T., Wu,P.Y., Cheng,Y.M. and Huang,Y.F.
    Tissue Inhibitor of Metalloproteinase 3: Unravelling Its Biological Function and Significance in Oncology
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2023
  4. Bhattacharjee,A., Singh,N., Kumar,P. and Katti,D.S.
    Sulfated carboxymethylcellulose mediated enhancement of Timp3 efficacy synergistically attenuates osteoarthritis through inhibition of NFkappaB and JNK
    Carbohydr Polym (2023) 316, 121061-121061. PubMed  Europe PubMed DOI
  5. Coates-Park,S., Lazaroff,C., Gurung,S., Rich,J., Colladay,A., O'Neill,M., Butler,G.S., Overall,C.M., Stetler-Stevenson,W.G. and Peeney,D.
    Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9
    Matrix Biol (2023) 123, 59-70. PubMed  Europe PubMed DOI
    6. 2022
  6. Spano,D.P. and Scilabra,S.D.
    Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding
    Membranes (Basel) (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
  7. Tayman,M.A. and Koyuncu,I.
    Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis
    Biotech Histochem (2022) , 1-6. PubMed  Europe PubMed DOI
  8. Yang,C.Y., Bonelli,S., Calligaris,M., Carreca,A.P., Muller,S.A., Lichtenthaler,S.F., Troeberg,L. and Scilabra,S.D.
    Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State
    Membranes (Basel) (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2021
  9. Aldughaim,M.S., Alsaffar,F. and Barker,M.D.
    Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site
    Molecules (2021) 26, 625-625. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2020
  10. Carreca,A.P., Pravata,V.M., Markham,M., Bonelli,S., Murphy,G., Nagase,H., Troeberg,L. and Scilabra,S.D.
    TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1
    Sci Rep (2020) 10, 12067-12067. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Chang,J.H., Lai,T.C., Yang,P.J., Shih,P.C., Yang,Y.C., Lee,K.L., Liu,T.C., Tsao,T.C., Yang,S.F. and Chien,M.H.
    Associations of TIMP-3 Genetic Polymorphisms with EGFR Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Er,A., Coskun,D., Bahcivan,E. and Dik,B.
    Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain
    Iran J Basic Med Sci (2020) 23, 1328-1334. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. Fan,D. and Kassiri,Z.
    Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology
    Front Physiol (2020) 11, 661-661. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Fan,H. and Zhang,W.
    Overexpression of Linc 4930556M19Rik Suppresses High Glucose-Triggered Podocyte Apoptosis, Fibrosis and Inflammation via the miR-27a-3p/Metalloproteinase 3 (TIMP3) Axis in Diabetic Nephropathy
    Med Sci Monit (2020) 26, e925361-e925361. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Fujii,T., Duarte,S., Lee,E., Ke,B., Busuttil,R.W. and Coito,A.J.
    Tissue inhibitor of metalloproteinase 3 deficiency disrupts the hepatocyte E-cadherin/beta-catenin complex and induces cell death in liver ischemia/reperfusion injury
    Liver Transpl (2020) 26, 113-126. PubMed  Europe PubMed DOI  K
  16. Gu,C., Luo,Y., Zhang,S., Xu,J., Zhang,J., Ju,H., Liu,J., Zhang,L., Zhang,Y., Wu,L., Xie,E., Xu,T. and Pan,S.
    MAb NJ001 inhibits lung adenocarcinoma invasiveness by directly regulating TIMP-3 promoter activity via FOXP1 binding sites
    Thorac Cancer (2020) PubMed  Europe PubMed DOI  K
  17. Qiu,Y., Maione,F., Capano,S., Meda,C., Picconi,O., Brundu,S., Pisacane,A., Sapino,A., Palladino,C., Barillari,G., Monini,P., Bussolino,F., Ensoli,B., Sgadari,C. and Giraudo,E.
    HIV-protease inhibitors block HPV16-induced murine cervical carcinoma and promote vessel normalization in association with MMP-9 inhibition and TIMP-3 induction
    Mol Cancer Ther (2020) PubMed  Europe PubMed DOI  I
  18. Rai,G.P. and Baird,S.K.
    Tissue inhibitor of matrix metalloproteinase-3 has both anti-metastatic and anti-tumourigenic properties
    Clin Exp Metastasis (2020) 37, 69-76. PubMed  Europe PubMed DOI
    19. 2019
  19. Dewing,J.M., Carare,R.O., Lotery,A.J. and Ratnayaka,J.A.
    The diverse roles of TIMP-3: insights into degenerative diseases of the senescent retina and brain
    Cells (2019) 9 PubMed  Europe PubMed DOI
  20. Qi,J.H., Bell,B., Singh,R., Batoki,J., Wolk,A., Cutler,A., Prayson,N., Ali,M., Stoehr,H. and Anand-Apte,B.
    Sorsby fundus dystrophy mutation in tissue inhibitor of metalloproteinase 3 (TIMP3) promotes choroidal neovascularization via a fibroblast growth factor-dependent mechanism
    Sci Rep (2019) 9, 17429-17429. PubMed  Europe PubMed DOI  M
  21. Su,C.W., Lin,C.W., Yang,W.E. and Yang,S.F.
    TIMP-3 as a therapeutic target for cancer
    Ther Adv Med Oncol (2019) 11, 1758835919864247-1758835919864247. PubMed  Europe PubMed DOI  PMC  EPMC  T
    22. 2017
  22. Miller,B., Spevak,L., Lukashova,L., Javaheri,B., Pitsillides,A.A., Boskey,A., Bou-Gharios,G. and Carriero,A.
    Altered bone mechanics, architecture and composition in the skeleton of TIMP-3-deficient mice
    Calcif Tissue Int (2017) 100, 631-640. PubMed  Europe PubMed DOI  K
    23. 2016
  23. Guo,C., Tsigkou,A. and Lee,M.H.
    ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4
    Biomed Rep (2016) 4, 73-78. PubMed  Europe PubMed DOI  PMC  EPMC  I
    24. 2014
  24. Tsai,H.T., Hsieh,M.J., Chiou,H.L., Lee,H.L., Hsin,M.C., Liou,Y.S., Yang,C.C., Yang,S.F. and Kuo,W.H.
    TIMP-3 -1296 T>C and TIMP-4 -55 T>C gene polymorphisms play a role in the susceptibility of hepatocellular carcinoma among women
    Tumour Biol (2014) 35, 8999-9007. PubMed  Europe PubMed DOI  M
    25. 2013
  25. Basu,R., Lee,J., Morton,J.S., Takawale,A., Fan,D., Kandalam,V., Wang,X., Davidge,S.T. and Kassiri,Z.
    TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension
    Cardiovasc Res (2013) 98, 360-371. PubMed  Europe PubMed DOI
  26. Kobayashi,N., Hanaoka,M., Droma,Y., Ito,M., Katsuyama,Y., Kubo,K. and Ota,M.
    Polymorphisms of the tissue inhibitor of metalloproteinase 3 gene are associated with resistance to high-altitude pulmonary edema (HAPE) in a Japanese population: a case control study using polymorphic microsatellite markers
    PLoS ONE (2013) 8, e71993-e71993. PubMed  Europe PubMed DOI  PMC  EPMC  M
    27. 2012
  27. Basu,R., Lee,J., Wang,Z., Patel,V.B., Fan,D., Das,S.K., Liu,G.C., John,R., Scholey,J.W., Oudit,G.Y. and Kassiri,Z.
    Loss of TIMP3 selectively exacerbates diabetic nephropathy
    Am J Physiol Renal Physiol (2012) 303, F1341-F1352. PubMed  Europe PubMed DOI  K
  28. Basu,R., Fan,D., Kandalam,V., Lee,J., Das,S.K., Wang,X.H., Baldwin,T.A., Oudit,G.Y. and Kassiri,Z.
    Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II
    J Biol Chem (2012) 287, 44083-44096. PubMed  Europe PubMed DOI  K  U
  29. Nieuwesteeg,M.A., Walsh,L.A., Fox,M.A. and Damjanovski,S.
    Domain specific overexpression of TIMP-2 and TIMP-3 reveals MMP-independent functions of TIMPs during Xenopus laevis development
    Biochem Cell Biol (2012) 90, 585-595. PubMed  Europe PubMed DOI
  30. Tian,H., Huang,M.L., Liu,K.Y., Jia,Z.B., Sun,L., Jiang,S.L., Liu,W., Kinkaid,H.Y., Wu,J. and Li,R.K.
    Inhibiting matrix metalloproteinase by cell-based TIMP-3 gene transfer effectively treats acute and chronic ischemic cardiomyopathy
    Cell Transplant (2012) 21, 1039-1053. PubMed  Europe PubMed DOI  U
  31. Troeberg,L., Mulloy,B., Ghosh,P., Lee,M.H., Murphy,G. and Nagase,H.
    Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex
    Biochem J (2012) 443, 307-315. PubMed  Europe PubMed DOI
    32. 2011
  32. George,S.J., Wan,S., Hu,J., Macdonald,R., Johnson,J.L. and Baker,A.H.
    Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy
    Circulation (2011) 124, S135-S142. PubMed  Europe PubMed DOI  U
  33. Kallio,J.P., Hopkins-Donaldson,S., Baker,A.H. and Kahari,V.M.
    TIMP-3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway
    Int J Cancer (2011) 128, 991-996. PubMed  Europe PubMed DOI
  34. Lianxin,D., Xin,S., Yan,W., Dan,X., Xingang,G. and Di,Z.
    Construction of prokaryotic vector of Timp-3
    Proc Int Conf Hum Health Biomed Eng , HHBE (2011) 2011, 565-568. DOI  E
  35. Nunes,G.L., Simoes,A., Dyszy,F.H., Shida,C.S., Juliano,M.A., Juliano,L., Gesteira,T.F., Nader,H.B., Murphy,G., Chaffotte,A.F., Goldberg,M.E., Tersariol,I.L. and Almeida,P.C.
    Mechanism of heparin acceleration of tissue inhibitor of metalloproteases-1 (TIMP-1) degradation by the human neutrophil elastase
    PLoS ONE (2011) 6, e21525-e21525. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2010
  36. Bernot,D., Barruet,E., Poggi,M., Bonardo,B., Alessi,M.C. and Peiretti,F.
    Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation
    J Biol Chem (2010) 285, 6508-6514. PubMed  Europe PubMed DOI
  37. Lim,N.H., Kashiwagi,M., Visse,R., Jones,J., Enghild,J.J., Brew,K. and Nagase,H.
    Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
    Biochem J (2010) 431, 113-122. PubMed  Europe PubMed DOI
  38. Murthy,A., Defamie,V., Smookler,D.S., Di Grappa,M.A., Horiuchi,K., Federici,M., Sibilia,M., Blobel,C.P. and Khokha,R.
    Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice
    J Clin Invest (2010) 120, 2731-2744. PubMed  Europe PubMed DOI  PMC  EPMC
    39. 2009
  39. Baba,Y., Yasuda,O., Takemura,Y., Ishikawa,Y., Ohishi,M., Iwanami,J., Mogi,M., Doe,N., Horiuchi,M., Maeda,N., Fukuo,K. and Rakugi,H.
    Timp-3 deficiency impairs cognitive function in mice
    Lab Invest (2009) 89, 1340-1347. PubMed  Europe PubMed DOI  K
  40. Hartmann,C., El-Gindi,J., Lohmann,C., Lischper,M., Zeni,P. and Galla,H.J.
    TIMP-3: a novel target for glucocorticoid signaling at the blood-brain barrier
    Biochem Biophys Res Commun (2009) 390, 182-186. PubMed  Europe PubMed DOI
  41. Kassiri,Z., Defamie,V., Hariri,M., Oudit,G.Y., Anthwal,S., Dawood,F., Liu,P. and Khokha,R.
    Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart
    J Biol Chem (2009) 284, 29893-29904. PubMed  Europe PubMed DOI
  42. Troeberg,L., Fushimi,K., Scilabra,S.D., Nakamura,H., Dive,V., Thogersen,I.B., Enghild,J.J. and Nagase,H.
    The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
    Matrix Biol (2009) 28, 463-469. PubMed  Europe PubMed DOI
    43. 2008
  43. Chetty,C., Lakka,S.S., Bhoopathi,P., Kunigal,S., Geiss,R. and Rao,J.S.
    Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer
    Cancer Res (2008) 68, 4736-4745. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Gu,P., Xing,X., Tanzer,M., Rocken,C., Weichert,W., Ivanauskas,A., Pross,M., Peitz,U., Malfertheiner,P., Schmid,R.M. and Ebert,M.P.
    Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas
    Neoplasia (2008) 10, 563-572. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Hoe,H.S., Cooper,M. and Burns,M.
    The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis
    Chemtracts (2008) 21, 233-235.
  46. Rapti,M., Atkinson,S.J., Lee,M.H., Trim,A., Moss,M. and Murphy,G.
    The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition
    Biochem J (2008) 411, 433-439. PubMed  Europe PubMed DOI
  47. Wisniewska,M., Goettig,P., Maskos,K., Belouski,E., Winters,D., Hecht,R., Black,R. and Bode,W.
    Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex
    J Mol Biol (2008) 381, 1307-1319. PubMed  Europe PubMed DOI  S
  48. Zhang,Y., Qian,H., Lin,C., Lang,J., Xiang,Y., Fu,M., Zhang,X. and Liang,X.
    Adenovirus carrying TIMP-3: a potential tool for cervical cancer treatment
    Gynecol Oncol (2008) 108, 234-240. PubMed  Europe PubMed DOI  U
    49. 2007
  49. Hoe,H.S., Cooper,M.J., Burns,M.P., Lewis,P.A., van der Brug,M., Chakraborty,G., Cartagena,C.M., Pak,D.T., Cookson,M.R. and Rebeck,G.W.
    The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis
    J Neurosci (2007) 27, 10895-10905. PubMed  Europe PubMed DOI
  50. Lee,M.H., Atkinson,S. and Murphy,G.
    Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1
    J Biol Chem (2007) 282, 6887-6898. PubMed  Europe PubMed DOI
  51. Martin,E.L., Sheikh,T.A., Leco,K.J., Lewis,J.F. and Veldhuizen,R.A.
    Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult
    Am J Physiol Lung Cell Mol Physiol (2007) 293, L779-L789. PubMed  Europe PubMed DOI  K
  52. Tian,H., Cimini,M., Fedak,P.W., Altamentova,S., Fazel,S., Huang,M.L., Weisel,R.D. and Li,R.K.
    TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction
    J Mol Cell Cardiol (2007) 43, 733-743. PubMed  Europe PubMed DOI  K
  53. Wayne,G.J., Deng,S.J., Amour,A., Borman,S., Matico,R., Carter,H.L. and Murphy,G.
    TIMP-3 inhibition of ADAMTS-4 (aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4
    J Biol Chem (2007) 282, 20991-20998. PubMed  Europe PubMed DOI
  54. Zhang,H., Wang,Y.S., Han,G. and Shi,Y.
    TIMP-3 gene transfection suppresses invasive and metastatic capacity of human hepatocarcinoma cell line HCC-7721
    Hepatobiliary Pancreat Dis Int (2007) 6, 487-491. PubMed  Europe PubMed
    55. 2006
  55. [YEAR:26-9-2006]Cruz-Munoz,W., Kim,I. and Khokha,R.
    TIMP-3 deficiency in the host, but not in the tumor, enhances tumor growth and angiogenesis
    Oncogene (26-9-2006) 25, 650-655. PubMed  Europe PubMed DOI
  56. [YEAR:1-9-2006]Pinto,A.F., Terra,R.M., Guimaraes,J.A., Kashiwagi,M., Nagase,H., Serrano,S.M. and Fox,J.W.
    Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction
    Biochem Biophys Res Commun (1-9-2006) 347, 641-648. PubMed  Europe PubMed DOI
  57. [YEAR:14-6-2006]Wang,W.M., Ge,G., Lim,N.H., Nagase,H. and Greenspan,D.S.
    TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2
    Biochem J (14-6-2006) 398, 515-519. PubMed  Europe PubMed DOI  PMC  EPMC
    58. 2005
  58. [YEAR:14-4-2005]Akowuah,E.F., Gray,C., Lawrie,A., Sheridan,P.J., Su,C.H., Bettinger,T., Brisken,A.F., Gunn,J., Crossman,D.C., Francis,S.E., Baker,A.H. and Newman,C.M.
    Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model
    Gene Ther (14-4-2005) 12, 1154-1157. PubMed  Europe PubMed DOI
  59. [YEAR:1-6-2005]Brueckl,W.M., Grombach,J., Wein,A., Ruckert,S., Porzner,M., Dietmaier,W., Rummele,P., Croner,R.S., Boxberger,F., Kirchner,T., Hohenberger,W., Hahn,E.G. and Jung,A.
    Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) are found frequently in human colorectal tumours displaying either microsatellite stability (MSS) or instability (MSI)
    Cancer Lett (1-6-2005) 223, 137-142. PubMed  Europe PubMed DOI
  60. Fendrich,V., Slater,E.P., Heinmoller,E., Ramaswamy,A., Celik,I., Nowak,O., Chaloupka,B., Gerdes,B. and Bartsch,D.K.
    Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas
    Pancreas (2005) 30, e40-e45. PubMed  Europe PubMed
  61. Johnson,T.W., Wu,Y.X., Herdeg,C., Baumbach,A., Newby,A.C., Karsch,K.R. and Oberhoff,M.
    Stent-based delivery of tissue inhibitor of metalloproteinase-3 adenovirus inhibits neointimal formation in porcine coronary arteries
    Arterioscler Thromb Vasc Biol (2005) 25, 754-759. PubMed  Europe PubMed DOI
  62. Lai,H.J. and Lo,S.J.
    Epigenetic methylation of TIMP-3 may play a role in HBV-associated hepatocellular carcinoma
    Chang Gung Med J (2005) 28, 453-455. PubMed  Europe PubMed
  63. [YEAR:13-10-2005]Langton,K.P., McKie,N., Smith,B.M., Brown,N.J. and Barker,M.D.
    Sorsby's fundus dystrophy mutations impair turnover of TIMP-3 by retinal pigment epithelial cells
    Hum Mol Genet (13-10-2005) 14, 3579-3586. PubMed  Europe PubMed DOI  M
  64. [YEAR:1-4-2005]Martin,E.L., McCaig,L.A., Moyer,B.Z., Pape,M.C., Leco,K.J., Lewis,J.F. and Veldhuizen,R.A.
    Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia
    Am J Physiol Lung Cell Mol Physiol (1-4-2005) 289, L244-L251. PubMed  Europe PubMed DOI  K
  65. [YEAR:3-8-2005]Wei,S., Kashiwagi,M., Kota,S., Xie,Z., Nagase,H. and Brew,K.
    Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme
    J Biol Chem (3-8-2005) 280, 32877-32882. PubMed  Europe PubMed DOI
    66. 2004
  66. Edwards,D.R.
    TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges
    J Pathol (2004) 202, 391-394. PubMed  Europe PubMed DOI
  67. [YEAR:19-7-2004]Fedak,P.W., Smookler,D.S., Kassiri,Z., Ohno,N., Leco,K.J., Verma,S., Mickle,D.A., Watson,K.L., Hojilla,C.V., Cruz,W., Weisel,R.D., Li,R.K. and Khokha,R.
    TIMP-3 deficiency leads to dilated cardiomyopathy
    Circulation (19-7-2004) 110, 2401-2409. PubMed  Europe PubMed DOI  K
  68. Han,X., Zhang,H., Jia,M., Han,G. and Jiang,W.
    Expression of TIMP-3 gene by construction of a eukaryotic cell expression vector and its role in reduction of metastasis in a human breast cancer cell line
    Cell Mol Immunol (2004) 1, 308-310. PubMed  Europe PubMed
  69. [YEAR:16-7-2004]Klenotic,P.A., Munier,F.L., Marmorstein,L.Y. and Anand-Apte,B.
    Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations
    J Biol Chem (16-7-2004) 279, 30469-30473. PubMed  Europe PubMed DOI
  70. [YEAR:12-8-2004]Lee,M.H., Rapti,M. and Murphy,G.
    Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme
    J Biol Chem (12-8-2004) 279, 45121-45129. PubMed  Europe PubMed DOI
  71. Span,P.N., Lindberg,R.L., Manders,P., Tjan-Heijnen,V.C., Heuvel,J.J., Beex,L.V. and Sweep,C.G.
    Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success
    J Pathol (2004) 202, 395-402. PubMed  Europe PubMed DOI
  72. [YEAR:16-12-2004]Zhao,H., Bernardo,M.M., Osenkowski,P., Sohail,A., Pei,D., Nagase,H., Kashiwagi,M., Soloway,P.D., DeClerck,Y.A. and Fridman,R.
    Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation
    J Biol Chem (16-12-2004) 279, 8592-8601. PubMed  Europe PubMed DOI  I
    73. 2003
  73. [YEAR:20-5-2003]Arris,C.E., Bevitt,D.J., Mohamed,J., Li,Z., Langton,K.P., Barker,M.D., Clarke,M.P. and McKie,N.
    Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients
    Biochim Biophys Acta (20-5-2003) 1638, 20-28. PubMed  Europe PubMed DOI  M
  74. [YEAR:15-9-2003]Gill,S.E., Pape,M.C., Khokha,R., Watson,A.J. and Leco,K.J.
    A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis
    Dev Biol (15-9-2003) 261, 313-323. PubMed  Europe PubMed DOI  K
  75. [YEAR:15-4-2003]Lee,M.H., Dodds,P., Verma,V., Maskos,K., Knauper,V. and Murphy,G.
    Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme
    Biochem J (15-4-2003) 371, 369-376. PubMed  Europe PubMed DOI  PMC  EPMC
  76. Martin,E.L., Moyer,B.Z., Pape,M.C., Starcher,B., Leco,K.J. and Veldhuizen,R.A.
    Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
    Am J Physiol Lung Cell Mol Physiol (2003) 285, L1222-L1232. PubMed  Europe PubMed DOI
  77. Qi,J.H., Ebrahem,Q., Moore,N., Murphy,G., Claesson-Welsh,L., Bond,M., Baker,A. and Anand-Apte,B.
    A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
    Nat Med (2003) 9, 407-415. PubMed  Europe PubMed DOI
  78. Soboleva,G., Geis,B., Schrewe,H. and Weber,B.H.
    Sorsby fundus dystrophy mutation Timp3(S156C) affects the morphological and biochemical phenotype but not metalloproteinase homeostasis
    J Cell Physiol (2003) 197, 149-156. PubMed  Europe PubMed DOI
  79. Suzuki,H., Nezaki,Y., Kuno,E., Sugiyama,I., Mizutani,A. and Tsukagoshi,N.
    Functional roles of the tissue inhibitor of metalloproteinase 3 (TIMP-3) during ascorbate-induced differentiation of osteoblastic MC3T3-E1 cells
    Biosci Biotechnol Biochem (2003) 67, 1737-1743. PubMed  Europe PubMed DOI
    80. 2002
  80. [YEAR:19-4-2002]Bond,M., Murphy,G., Bennett,M.R., Newby,A.C. and Baker,A.H.
    Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway
    J Biol Chem (19-4-2002) 277, 13787-13795. PubMed  Europe PubMed DOI
  81. [YEAR:5-6-2002]Lee,M.H., Verma,V., Maskos,K., Becherer,J.D., Knauper,V., Dodds,P., Amour,A. and Murphy,G.
    The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3
    FEBS Lett (5-6-2002) 520, 102-106. PubMed  Europe PubMed DOI
  82. [YEAR:15-5-2002]Lee,M.H., Verma,V., Maskos,K., Nath,D., Knauper,V., Dodds,P., Amour,A. and Murphy,G.
    Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme
    Biochem J (15-5-2002) 364, 227-234. PubMed  Europe PubMed  PMC  EPMC
  83. Lee,M.H., Maskos,K., Knauper,V., Dodds,P. and Murphy,G.
    Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering
    Protein Sci (2002) 11, 2493-2503. PubMed  Europe PubMed DOI  PMC  EPMC
  84. [YEAR:9-10-2002]Majid,M.A., Smith,V.A., Easty,D.L., Baker,A.H. and Newby,A.C.
    Sorsby's fundus dystrophy mutant tissue inhibitors of metalloproteinase-3 induce apoptosis of retinal pigment epithelial and MCF-7 cells
    FEBS Lett (9-10-2002) 529, 281-285. PubMed  Europe PubMed DOI
  85. Wallace,J.A., Alexander,S., Estrada,E.Y., Hines,C., Cunningham,L.A. and Rosenberg,G.A.
    Tissue inhibitor of metalloproteinase-3 is associated with neuronal death in reperfusion injury
    J Cereb Blood Flow Metab (2002) 22, 1303-1310. PubMed  Europe PubMed DOI
    86. 2001
  86. [YEAR:13-4-2001]Hashimoto,G., Aoki,T., Nakamura,H., Tanzawa,K. and Okada,Y.
    Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)
    FEBS Lett (13-4-2001) 494, 192-195. PubMed  Europe PubMed DOI
  87. [YEAR:8-4-2001]Hung,C.C., Chen,Y.H., Tsai,M.T. and Chen,C.H.
    Systematic search for mutations in the human tissue inhibitor of metalloproteinases-3 (TIMP-3) gene on chromosome 22 and association study with schizophrenia
    Am J Med Genet (8-4-2001) 105, 275-278. PubMed  Europe PubMed DOI
  88. [YEAR:20-4-2001]Kashiwagi,M., Tortorella,M., Nagase,H. and Brew,K.
    TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)
    J Biol Chem (20-4-2001) 276, 12501-12504. PubMed  Europe PubMed DOI
  89. [YEAR:26-1-2001]Lee,M.H., Knauper,V., Becherer,J.D. and Murphy,G.
    Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase
    Biochem Biophys Res Commun (26-1-2001) 280, 945-950. PubMed  Europe PubMed DOI
  90. Whiteside,E.J., Jackson,M.M., Herington,A.C., Edwards,D.R. and Harvey,M.B.
    Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos
    Biol Reprod (2001) 64, 1331-1337. PubMed  Europe PubMed
    91. 1999
  91. [YEAR:16-4-1999]Butler,G.S., Apte,S.S., Willenbrock,F. and Murphy,G.
    Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions
    J Biol Chem (16-4-1999) 274, 10846-10851. PubMed  Europe PubMed DOI
    92. 1998
  92. [YEAR:11-9-1998]Amour,A., Slocombe,P.M., Webster,A., Butler,M., Knight,C.G., Smith,B.J., Stephens,P.E., Shelley,C., Hutton,M., Knauper,V., Docherty,A.J. and Murphy,G.
    TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3
    FEBS Lett (11-9-1998) 435, 39-44. PubMed  Europe PubMed DOI
    93. 1997
  93. Gomez,D.E., Alonso,D.F., Yoshiji,H. and Thorgeirsson,U.P.
    Tissue inhibitors of metalloproteinases: structure, regulation and biological functions
    Eur J Cell Biol (1997) 74, 111-122. PubMed  Europe PubMed
    94. 1995
  94. Apte,S.S., Olsen,B.R. and Murphy,G.
    The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family
    J Biol Chem (1995) 270, 14313-14318. PubMed  Europe PubMed DOI
    95. 1994
  95. Apte,S.S., Mattei,M.G. and Olsen,B.R.
    Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22
    Genomics (1994) 19, 86-90. PubMed  Europe PubMed DOI
  96. Leco,K.J., Khokha,R., Pavloff,N., Hawkes,S.P. and Edwards,D.R.
    Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues
    J Biol Chem (1994) 269, 9352-9360. PubMed  Europe PubMed
    97. 1992
  97. Pavloff,N., Staskus,P.W., Kishnani,N.S. and Hawkes,S.P.
    A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family
    J Biol Chem (1992) 267, 17321-17326. PubMed  Europe PubMed
  98. Yang,T.T. and Hawkes,S.P.
    Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts
    Proc Natl Acad Sci U S A (1992) 89, 10676-10680. PubMed  Europe PubMed DOI  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use