Literature for inhibitor I35.003: timp-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, T Target, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Betts,J.H.J. and Troeberg,L. Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy Mol Vis (2024) 30, 74-91. PubMed Europe PubMed PMC EPMC V
Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E. Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target Basic Clin Pharmacol Toxicol (2024) 134, 727-736. PubMed Europe PubMed DOI L
Lee,W.T., Wu,P.Y., Cheng,Y.M. and Huang,Y.F. Tissue Inhibitor of Metalloproteinase 3: Unravelling Its Biological Function and Significance in Oncology Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC V

2023

Bhattacharjee,A., Singh,N., Kumar,P. and Katti,D.S. Sulfated carboxymethylcellulose mediated enhancement of Timp3 efficacy synergistically attenuates osteoarthritis through inhibition of NFkappaB and JNK Carbohydr Polym (2023) 316, 121061-121061. PubMed Europe PubMed DOI
Coates-Park,S., Lazaroff,C., Gurung,S., Rich,J., Colladay,A., O'Neill,M., Butler,G.S., Overall,C.M., Stetler-Stevenson,W.G. and Peeney,D. Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9 Matrix Biol (2023) 123, 59-70. PubMed Europe PubMed DOI

2022

Spano,D.P. and Scilabra,S.D. Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding Membranes (Basel) (2022) 12 PubMed Europe PubMed DOI PMC EPMC V
Tayman,M.A. and Koyuncu,I. Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis Biotech Histochem (2022) , 1-6. PubMed Europe PubMed DOI
Yang,C.Y., Bonelli,S., Calligaris,M., Carreca,A.P., Muller,S.A., Lichtenthaler,S.F., Troeberg,L. and Scilabra,S.D. Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State Membranes (Basel) (2022) 12 PubMed Europe PubMed DOI PMC EPMC

2021

Aldughaim,M.S., Alsaffar,F. and Barker,M.D. Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site Molecules (2021) 26, 625-625. PubMed Europe PubMed DOI PMC EPMC

2020

Carreca,A.P., Pravata,V.M., Markham,M., Bonelli,S., Murphy,G., Nagase,H., Troeberg,L. and Scilabra,S.D. TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1 Sci Rep (2020) 10, 12067-12067. PubMed Europe PubMed DOI PMC EPMC
Chang,J.H., Lai,T.C., Yang,P.J., Shih,P.C., Yang,Y.C., Lee,K.L., Liu,T.C., Tsao,T.C., Yang,S.F. and Chien,M.H. Associations of TIMP-3 Genetic Polymorphisms with EGFR Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Er,A., Coskun,D., Bahcivan,E. and Dik,B. Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain Iran J Basic Med Sci (2020) 23, 1328-1334. PubMed Europe PubMed DOI PMC EPMC I
Fan,D. and Kassiri,Z. Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology Front Physiol (2020) 11, 661-661. PubMed Europe PubMed DOI PMC EPMC
Fan,H. and Zhang,W. Overexpression of Linc 4930556M19Rik Suppresses High Glucose-Triggered Podocyte Apoptosis, Fibrosis and Inflammation via the miR-27a-3p/Metalloproteinase 3 (TIMP3) Axis in Diabetic Nephropathy Med Sci Monit (2020) 26, e925361-e925361. PubMed Europe PubMed DOI PMC EPMC
Fujii,T., Duarte,S., Lee,E., Ke,B., Busuttil,R.W. and Coito,A.J. Tissue inhibitor of metalloproteinase 3 deficiency disrupts the hepatocyte E-cadherin/beta-catenin complex and induces cell death in liver ischemia/reperfusion injury Liver Transpl (2020) 26, 113-126. PubMed Europe PubMed DOI K
Gu,C., Luo,Y., Zhang,S., Xu,J., Zhang,J., Ju,H., Liu,J., Zhang,L., Zhang,Y., Wu,L., Xie,E., Xu,T. and Pan,S. MAb NJ001 inhibits lung adenocarcinoma invasiveness by directly regulating TIMP-3 promoter activity via FOXP1 binding sites Thorac Cancer (2020) PubMed Europe PubMed DOI K
Qiu,Y., Maione,F., Capano,S., Meda,C., Picconi,O., Brundu,S., Pisacane,A., Sapino,A., Palladino,C., Barillari,G., Monini,P., Bussolino,F., Ensoli,B., Sgadari,C. and Giraudo,E. HIV-protease inhibitors block HPV16-induced murine cervical carcinoma and promote vessel normalization in association with MMP-9 inhibition and TIMP-3 induction Mol Cancer Ther (2020) PubMed Europe PubMed DOI I
Rai,G.P. and Baird,S.K. Tissue inhibitor of matrix metalloproteinase-3 has both anti-metastatic and anti-tumourigenic properties Clin Exp Metastasis (2020) 37, 69-76. PubMed Europe PubMed DOI

2019

Dewing,J.M., Carare,R.O., Lotery,A.J. and Ratnayaka,J.A. The diverse roles of TIMP-3: insights into degenerative diseases of the senescent retina and brain Cells (2019) 9 PubMed Europe PubMed DOI
Qi,J.H., Bell,B., Singh,R., Batoki,J., Wolk,A., Cutler,A., Prayson,N., Ali,M., Stoehr,H. and Anand-Apte,B. Sorsby fundus dystrophy mutation in tissue inhibitor of metalloproteinase 3 (TIMP3) promotes choroidal neovascularization via a fibroblast growth factor-dependent mechanism Sci Rep (2019) 9, 17429-17429. PubMed Europe PubMed DOI M
Su,C.W., Lin,C.W., Yang,W.E. and Yang,S.F. TIMP-3 as a therapeutic target for cancer Ther Adv Med Oncol (2019) 11, 1758835919864247-1758835919864247. PubMed Europe PubMed DOI PMC EPMC T

2017

Miller,B., Spevak,L., Lukashova,L., Javaheri,B., Pitsillides,A.A., Boskey,A., Bou-Gharios,G. and Carriero,A. Altered bone mechanics, architecture and composition in the skeleton of TIMP-3-deficient mice Calcif Tissue Int (2017) 100, 631-640. PubMed Europe PubMed DOI K

2016

Guo,C., Tsigkou,A. and Lee,M.H. ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4 Biomed Rep (2016) 4, 73-78. PubMed Europe PubMed DOI PMC EPMC I

2014

Tsai,H.T., Hsieh,M.J., Chiou,H.L., Lee,H.L., Hsin,M.C., Liou,Y.S., Yang,C.C., Yang,S.F. and Kuo,W.H. TIMP-3 -1296 T>C and TIMP-4 -55 T>C gene polymorphisms play a role in the susceptibility of hepatocellular carcinoma among women Tumour Biol (2014) 35, 8999-9007. PubMed Europe PubMed DOI M

2013

Basu,R., Lee,J., Morton,J.S., Takawale,A., Fan,D., Kandalam,V., Wang,X., Davidge,S.T. and Kassiri,Z. TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension Cardiovasc Res (2013) 98, 360-371. PubMed Europe PubMed DOI
Kobayashi,N., Hanaoka,M., Droma,Y., Ito,M., Katsuyama,Y., Kubo,K. and Ota,M. Polymorphisms of the tissue inhibitor of metalloproteinase 3 gene are associated with resistance to high-altitude pulmonary edema (HAPE) in a Japanese population: a case control study using polymorphic microsatellite markers PLoS ONE (2013) 8, e71993-e71993. PubMed Europe PubMed DOI PMC EPMC M

2012

Basu,R., Lee,J., Wang,Z., Patel,V.B., Fan,D., Das,S.K., Liu,G.C., John,R., Scholey,J.W., Oudit,G.Y. and Kassiri,Z. Loss of TIMP3 selectively exacerbates diabetic nephropathy Am J Physiol Renal Physiol (2012) 303, F1341-F1352. PubMed Europe PubMed DOI K
Basu,R., Fan,D., Kandalam,V., Lee,J., Das,S.K., Wang,X.H., Baldwin,T.A., Oudit,G.Y. and Kassiri,Z. Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II J Biol Chem (2012) 287, 44083-44096. PubMed Europe PubMed DOI K U
Nieuwesteeg,M.A., Walsh,L.A., Fox,M.A. and Damjanovski,S. Domain specific overexpression of TIMP-2 and TIMP-3 reveals MMP-independent functions of TIMPs during Xenopus laevis development Biochem Cell Biol (2012) 90, 585-595. PubMed Europe PubMed DOI
Tian,H., Huang,M.L., Liu,K.Y., Jia,Z.B., Sun,L., Jiang,S.L., Liu,W., Kinkaid,H.Y., Wu,J. and Li,R.K. Inhibiting matrix metalloproteinase by cell-based TIMP-3 gene transfer effectively treats acute and chronic ischemic cardiomyopathy Cell Transplant (2012) 21, 1039-1053. PubMed Europe PubMed DOI U
Troeberg,L., Mulloy,B., Ghosh,P., Lee,M.H., Murphy,G. and Nagase,H. Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex Biochem J (2012) 443, 307-315. PubMed Europe PubMed DOI

2011

George,S.J., Wan,S., Hu,J., Macdonald,R., Johnson,J.L. and Baker,A.H. Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy Circulation (2011) 124, S135-S142. PubMed Europe PubMed DOI U
Kallio,J.P., Hopkins-Donaldson,S., Baker,A.H. and Kahari,V.M. TIMP-3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway Int J Cancer (2011) 128, 991-996. PubMed Europe PubMed DOI
Lianxin,D., Xin,S., Yan,W., Dan,X., Xingang,G. and Di,Z. Construction of prokaryotic vector of Timp-3 Proc Int Conf Hum Health Biomed Eng , HHBE (2011) 2011, 565-568. DOI E
Nunes,G.L., Simoes,A., Dyszy,F.H., Shida,C.S., Juliano,M.A., Juliano,L., Gesteira,T.F., Nader,H.B., Murphy,G., Chaffotte,A.F., Goldberg,M.E., Tersariol,I.L. and Almeida,P.C. Mechanism of heparin acceleration of tissue inhibitor of metalloproteases-1 (TIMP-1) degradation by the human neutrophil elastase PLoS ONE (2011) 6, e21525-e21525. PubMed Europe PubMed DOI PMC EPMC

2010

Bernot,D., Barruet,E., Poggi,M., Bonardo,B., Alessi,M.C. and Peiretti,F. Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation J Biol Chem (2010) 285, 6508-6514. PubMed Europe PubMed DOI
Lim,N.H., Kashiwagi,M., Visse,R., Jones,J., Enghild,J.J., Brew,K. and Nagase,H. Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications Biochem J (2010) 431, 113-122. PubMed Europe PubMed DOI
Murthy,A., Defamie,V., Smookler,D.S., Di Grappa,M.A., Horiuchi,K., Federici,M., Sibilia,M., Blobel,C.P. and Khokha,R. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice J Clin Invest (2010) 120, 2731-2744. PubMed Europe PubMed DOI PMC EPMC

2009

Baba,Y., Yasuda,O., Takemura,Y., Ishikawa,Y., Ohishi,M., Iwanami,J., Mogi,M., Doe,N., Horiuchi,M., Maeda,N., Fukuo,K. and Rakugi,H. Timp-3 deficiency impairs cognitive function in mice Lab Invest (2009) 89, 1340-1347. PubMed Europe PubMed DOI K
Hartmann,C., El-Gindi,J., Lohmann,C., Lischper,M., Zeni,P. and Galla,H.J. TIMP-3: a novel target for glucocorticoid signaling at the blood-brain barrier Biochem Biophys Res Commun (2009) 390, 182-186. PubMed Europe PubMed DOI
Kassiri,Z., Defamie,V., Hariri,M., Oudit,G.Y., Anthwal,S., Dawood,F., Liu,P. and Khokha,R. Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart J Biol Chem (2009) 284, 29893-29904. PubMed Europe PubMed DOI
Troeberg,L., Fushimi,K., Scilabra,S.D., Nakamura,H., Dive,V., Thogersen,I.B., Enghild,J.J. and Nagase,H. The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3 Matrix Biol (2009) 28, 463-469. PubMed Europe PubMed DOI

2008

Chetty,C., Lakka,S.S., Bhoopathi,P., Kunigal,S., Geiss,R. and Rao,J.S. Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer Cancer Res (2008) 68, 4736-4745. PubMed Europe PubMed DOI PMC EPMC
Gu,P., Xing,X., Tanzer,M., Rocken,C., Weichert,W., Ivanauskas,A., Pross,M., Peitz,U., Malfertheiner,P., Schmid,R.M. and Ebert,M.P. Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas Neoplasia (2008) 10, 563-572. PubMed Europe PubMed DOI PMC EPMC
Hoe,H.S., Cooper,M. and Burns,M. The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis Chemtracts (2008) 21, 233-235.
Rapti,M., Atkinson,S.J., Lee,M.H., Trim,A., Moss,M. and Murphy,G. The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition Biochem J (2008) 411, 433-439. PubMed Europe PubMed DOI
Wisniewska,M., Goettig,P., Maskos,K., Belouski,E., Winters,D., Hecht,R., Black,R. and Bode,W. Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex J Mol Biol (2008) 381, 1307-1319. PubMed Europe PubMed DOI S
Zhang,Y., Qian,H., Lin,C., Lang,J., Xiang,Y., Fu,M., Zhang,X. and Liang,X. Adenovirus carrying TIMP-3: a potential tool for cervical cancer treatment Gynecol Oncol (2008) 108, 234-240. PubMed Europe PubMed DOI U

2007

Hoe,H.S., Cooper,M.J., Burns,M.P., Lewis,P.A., van der Brug,M., Chakraborty,G., Cartagena,C.M., Pak,D.T., Cookson,M.R. and Rebeck,G.W. The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis J Neurosci (2007) 27, 10895-10905. PubMed Europe PubMed DOI
Lee,M.H., Atkinson,S. and Murphy,G. Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1 J Biol Chem (2007) 282, 6887-6898. PubMed Europe PubMed DOI
Martin,E.L., Sheikh,T.A., Leco,K.J., Lewis,J.F. and Veldhuizen,R.A. Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult Am J Physiol Lung Cell Mol Physiol (2007) 293, L779-L789. PubMed Europe PubMed DOI K
Tian,H., Cimini,M., Fedak,P.W., Altamentova,S., Fazel,S., Huang,M.L., Weisel,R.D. and Li,R.K. TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction J Mol Cell Cardiol (2007) 43, 733-743. PubMed Europe PubMed DOI K
Wayne,G.J., Deng,S.J., Amour,A., Borman,S., Matico,R., Carter,H.L. and Murphy,G. TIMP-3 inhibition of ADAMTS-4 (aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4 J Biol Chem (2007) 282, 20991-20998. PubMed Europe PubMed DOI
Zhang,H., Wang,Y.S., Han,G. and Shi,Y. TIMP-3 gene transfection suppresses invasive and metastatic capacity of human hepatocarcinoma cell line HCC-7721 Hepatobiliary Pancreat Dis Int (2007) 6, 487-491. PubMed Europe PubMed

2006

[YEAR:26-9-2006]Cruz-Munoz,W., Kim,I. and Khokha,R. TIMP-3 deficiency in the host, but not in the tumor, enhances tumor growth and angiogenesis Oncogene (26-9-2006) 25, 650-655. PubMed Europe PubMed DOI
[YEAR:1-9-2006]Pinto,A.F., Terra,R.M., Guimaraes,J.A., Kashiwagi,M., Nagase,H., Serrano,S.M. and Fox,J.W. Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction Biochem Biophys Res Commun (1-9-2006) 347, 641-648. PubMed Europe PubMed DOI
[YEAR:14-6-2006]Wang,W.M., Ge,G., Lim,N.H., Nagase,H. and Greenspan,D.S. TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2 Biochem J (14-6-2006) 398, 515-519. PubMed Europe PubMed DOI PMC EPMC

2005

[YEAR:14-4-2005]Akowuah,E.F., Gray,C., Lawrie,A., Sheridan,P.J., Su,C.H., Bettinger,T., Brisken,A.F., Gunn,J., Crossman,D.C., Francis,S.E., Baker,A.H. and Newman,C.M. Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model Gene Ther (14-4-2005) 12, 1154-1157. PubMed Europe PubMed DOI
[YEAR:1-6-2005]Brueckl,W.M., Grombach,J., Wein,A., Ruckert,S., Porzner,M., Dietmaier,W., Rummele,P., Croner,R.S., Boxberger,F., Kirchner,T., Hohenberger,W., Hahn,E.G. and Jung,A. Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) are found frequently in human colorectal tumours displaying either microsatellite stability (MSS) or instability (MSI) Cancer Lett (1-6-2005) 223, 137-142. PubMed Europe PubMed DOI
Fendrich,V., Slater,E.P., Heinmoller,E., Ramaswamy,A., Celik,I., Nowak,O., Chaloupka,B., Gerdes,B. and Bartsch,D.K. Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas Pancreas (2005) 30, e40-e45. PubMed Europe PubMed
Johnson,T.W., Wu,Y.X., Herdeg,C., Baumbach,A., Newby,A.C., Karsch,K.R. and Oberhoff,M. Stent-based delivery of tissue inhibitor of metalloproteinase-3 adenovirus inhibits neointimal formation in porcine coronary arteries Arterioscler Thromb Vasc Biol (2005) 25, 754-759. PubMed Europe PubMed DOI
Lai,H.J. and Lo,S.J. Epigenetic methylation of TIMP-3 may play a role in HBV-associated hepatocellular carcinoma Chang Gung Med J (2005) 28, 453-455. PubMed Europe PubMed
[YEAR:13-10-2005]Langton,K.P., McKie,N., Smith,B.M., Brown,N.J. and Barker,M.D. Sorsby's fundus dystrophy mutations impair turnover of TIMP-3 by retinal pigment epithelial cells Hum Mol Genet (13-10-2005) 14, 3579-3586. PubMed Europe PubMed DOI M
[YEAR:1-4-2005]Martin,E.L., McCaig,L.A., Moyer,B.Z., Pape,M.C., Leco,K.J., Lewis,J.F. and Veldhuizen,R.A. Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia Am J Physiol Lung Cell Mol Physiol (1-4-2005) 289, L244-L251. PubMed Europe PubMed DOI K
[YEAR:3-8-2005]Wei,S., Kashiwagi,M., Kota,S., Xie,Z., Nagase,H. and Brew,K. Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme J Biol Chem (3-8-2005) 280, 32877-32882. PubMed Europe PubMed DOI

2004

Edwards,D.R. TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges J Pathol (2004) 202, 391-394. PubMed Europe PubMed DOI
[YEAR:19-7-2004]Fedak,P.W., Smookler,D.S., Kassiri,Z., Ohno,N., Leco,K.J., Verma,S., Mickle,D.A., Watson,K.L., Hojilla,C.V., Cruz,W., Weisel,R.D., Li,R.K. and Khokha,R. TIMP-3 deficiency leads to dilated cardiomyopathy Circulation (19-7-2004) 110, 2401-2409. PubMed Europe PubMed DOI K
Han,X., Zhang,H., Jia,M., Han,G. and Jiang,W. Expression of TIMP-3 gene by construction of a eukaryotic cell expression vector and its role in reduction of metastasis in a human breast cancer cell line Cell Mol Immunol (2004) 1, 308-310. PubMed Europe PubMed
[YEAR:16-7-2004]Klenotic,P.A., Munier,F.L., Marmorstein,L.Y. and Anand-Apte,B. Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations J Biol Chem (16-7-2004) 279, 30469-30473. PubMed Europe PubMed DOI
[YEAR:12-8-2004]Lee,M.H., Rapti,M. and Murphy,G. Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme J Biol Chem (12-8-2004) 279, 45121-45129. PubMed Europe PubMed DOI
Span,P.N., Lindberg,R.L., Manders,P., Tjan-Heijnen,V.C., Heuvel,J.J., Beex,L.V. and Sweep,C.G. Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success J Pathol (2004) 202, 395-402. PubMed Europe PubMed DOI
[YEAR:16-12-2004]Zhao,H., Bernardo,M.M., Osenkowski,P., Sohail,A., Pei,D., Nagase,H., Kashiwagi,M., Soloway,P.D., DeClerck,Y.A. and Fridman,R. Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation J Biol Chem (16-12-2004) 279, 8592-8601. PubMed Europe PubMed DOI I

2003

[YEAR:20-5-2003]Arris,C.E., Bevitt,D.J., Mohamed,J., Li,Z., Langton,K.P., Barker,M.D., Clarke,M.P. and McKie,N. Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients Biochim Biophys Acta (20-5-2003) 1638, 20-28. PubMed Europe PubMed DOI M
[YEAR:15-9-2003]Gill,S.E., Pape,M.C., Khokha,R., Watson,A.J. and Leco,K.J. A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis Dev Biol (15-9-2003) 261, 313-323. PubMed Europe PubMed DOI K
[YEAR:15-4-2003]Lee,M.H., Dodds,P., Verma,V., Maskos,K., Knauper,V. and Murphy,G. Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme Biochem J (15-4-2003) 371, 369-376. PubMed Europe PubMed DOI PMC EPMC
Martin,E.L., Moyer,B.Z., Pape,M.C., Starcher,B., Leco,K.J. and Veldhuizen,R.A. Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis Am J Physiol Lung Cell Mol Physiol (2003) 285, L1222-L1232. PubMed Europe PubMed DOI
Qi,J.H., Ebrahem,Q., Moore,N., Murphy,G., Claesson-Welsh,L., Bond,M., Baker,A. and Anand-Apte,B. A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2 Nat Med (2003) 9, 407-415. PubMed Europe PubMed DOI
Soboleva,G., Geis,B., Schrewe,H. and Weber,B.H. Sorsby fundus dystrophy mutation Timp3(S156C) affects the morphological and biochemical phenotype but not metalloproteinase homeostasis J Cell Physiol (2003) 197, 149-156. PubMed Europe PubMed DOI
Suzuki,H., Nezaki,Y., Kuno,E., Sugiyama,I., Mizutani,A. and Tsukagoshi,N. Functional roles of the tissue inhibitor of metalloproteinase 3 (TIMP-3) during ascorbate-induced differentiation of osteoblastic MC3T3-E1 cells Biosci Biotechnol Biochem (2003) 67, 1737-1743. PubMed Europe PubMed DOI

2002

[YEAR:19-4-2002]Bond,M., Murphy,G., Bennett,M.R., Newby,A.C. and Baker,A.H. Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway J Biol Chem (19-4-2002) 277, 13787-13795. PubMed Europe PubMed DOI
[YEAR:5-6-2002]Lee,M.H., Verma,V., Maskos,K., Becherer,J.D., Knauper,V., Dodds,P., Amour,A. and Murphy,G. The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3 FEBS Lett (5-6-2002) 520, 102-106. PubMed Europe PubMed DOI
[YEAR:15-5-2002]Lee,M.H., Verma,V., Maskos,K., Nath,D., Knauper,V., Dodds,P., Amour,A. and Murphy,G. Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme Biochem J (15-5-2002) 364, 227-234. PubMed Europe PubMed PMC EPMC
Lee,M.H., Maskos,K., Knauper,V., Dodds,P. and Murphy,G. Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering Protein Sci (2002) 11, 2493-2503. PubMed Europe PubMed DOI PMC EPMC
[YEAR:9-10-2002]Majid,M.A., Smith,V.A., Easty,D.L., Baker,A.H. and Newby,A.C. Sorsby's fundus dystrophy mutant tissue inhibitors of metalloproteinase-3 induce apoptosis of retinal pigment epithelial and MCF-7 cells FEBS Lett (9-10-2002) 529, 281-285. PubMed Europe PubMed DOI
Wallace,J.A., Alexander,S., Estrada,E.Y., Hines,C., Cunningham,L.A. and Rosenberg,G.A. Tissue inhibitor of metalloproteinase-3 is associated with neuronal death in reperfusion injury J Cereb Blood Flow Metab (2002) 22, 1303-1310. PubMed Europe PubMed DOI

2001

[YEAR:13-4-2001]Hashimoto,G., Aoki,T., Nakamura,H., Tanzawa,K. and Okada,Y. Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4) FEBS Lett (13-4-2001) 494, 192-195. PubMed Europe PubMed DOI
[YEAR:8-4-2001]Hung,C.C., Chen,Y.H., Tsai,M.T. and Chen,C.H. Systematic search for mutations in the human tissue inhibitor of metalloproteinases-3 (TIMP-3) gene on chromosome 22 and association study with schizophrenia Am J Med Genet (8-4-2001) 105, 275-278. PubMed Europe PubMed DOI
[YEAR:20-4-2001]Kashiwagi,M., Tortorella,M., Nagase,H. and Brew,K. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5) J Biol Chem (20-4-2001) 276, 12501-12504. PubMed Europe PubMed DOI
[YEAR:26-1-2001]Lee,M.H., Knauper,V., Becherer,J.D. and Murphy,G. Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase Biochem Biophys Res Commun (26-1-2001) 280, 945-950. PubMed Europe PubMed DOI
Whiteside,E.J., Jackson,M.M., Herington,A.C., Edwards,D.R. and Harvey,M.B. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos Biol Reprod (2001) 64, 1331-1337. PubMed Europe PubMed

1999

[YEAR:16-4-1999]Butler,G.S., Apte,S.S., Willenbrock,F. and Murphy,G. Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions J Biol Chem (16-4-1999) 274, 10846-10851. PubMed Europe PubMed DOI

1998

[YEAR:11-9-1998]Amour,A., Slocombe,P.M., Webster,A., Butler,M., Knight,C.G., Smith,B.J., Stephens,P.E., Shelley,C., Hutton,M., Knauper,V., Docherty,A.J. and Murphy,G. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3 FEBS Lett (11-9-1998) 435, 39-44. PubMed Europe PubMed DOI

1997

Gomez,D.E., Alonso,D.F., Yoshiji,H. and Thorgeirsson,U.P. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions Eur J Cell Biol (1997) 74, 111-122. PubMed Europe PubMed

1995

Apte,S.S., Olsen,B.R. and Murphy,G. The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family J Biol Chem (1995) 270, 14313-14318. PubMed Europe PubMed DOI

1994

Apte,S.S., Mattei,M.G. and Olsen,B.R. Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22 Genomics (1994) 19, 86-90. PubMed Europe PubMed DOI
Leco,K.J., Khokha,R., Pavloff,N., Hawkes,S.P. and Edwards,D.R. Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues J Biol Chem (1994) 269, 9352-9360. PubMed Europe PubMed

1992

Pavloff,N., Staskus,P.W., Kishnani,N.S. and Hawkes,S.P. A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family J Biol Chem (1992) 267, 17321-17326. PubMed Europe PubMed
Yang,T.T. and Hawkes,S.P. Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts Proc Natl Acad Sci U S A (1992) 89, 10676-10680. PubMed Europe PubMed DOI PMC EPMC