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Literature for inhibitor I35.002: timp-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: S Structure, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Lin,X., Chen,Y., Zhong,B. and Yu,H.
    Cathepsin K and glycosaminoglycans differentially regulate matrix metalloproteinase activity in dentin under various pH conditions
    Int J Biol Macromol (2025) 327, 147486-147486. PubMed  Europe PubMed DOI  L
    2. 2024
  2. Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E.
    Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target
    Basic Clin Pharmacol Toxicol (2024) 134, 727-736. PubMed  Europe PubMed DOI  L
  3. Delrue,C. and Speeckaert,M.M.
    Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) as a Prognostic Biomarker in Acute Kidney Injury: A Narrative Review
    Diagnostics (Basel) (2024) 14 PubMed  Europe PubMed DOI  PMC  EPMC  V
  4. Gowtham,P., Girigoswami,K., Thirumalai,A., Harini,K., Pallavi,P. and Girigoswami,A.
    Association of TIMP2 418 G/C and MMP Gene Polymorphism with Risk of Urinary Cancers: Systematic Review and Meta-analysis
    Genet Test Mol Biomarkers (2024) 28, 83-90. PubMed  Europe PubMed DOI
  5. Leng,J., Li,L., Tu,H., Luo,Y., Cao,Z., Zhou,K., Rizvi,S.M.M., Tie,H. and Jiang,Y.
    Mechanism and clinical role of TIMP-2 and IGFBP-7 in cardiac surgery-associated acute kidney injury: A review
    Medicine (Baltimore) (2024) 103, e38124-e38124. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Rotenberg,N., Feldman,M., Shirian,J., Hockla,A., Radisky,E.S. and Shifman,J.M.
    Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple negative breast cancer cells
    J Biol Chem (2024) , 107867-107867. PubMed  Europe PubMed DOI
    7. 2023
  7. Abouhadid,M.A., Gawad,T.A.A., Gebaly,H.H.E., Abdallah,A.A., Refay,A.S.E., Helmy,N.M. and Allam,A.M.
    Urinary tissue inhibitor of metalloproteinase-2 as an early predictor for acute kidney injury in critically ill children
    Int J Health Sci (Qassim) (2023) 17, 22-28. PubMed  Europe PubMed  PMC  EPMC
  8. Barreto,J.N., Barreto,E.F., Mara,K.C., Rule,A.D., Lieske,J.C., Giesen,C.D., Thompson,C.A., Leung,N., Witzig,T.E. and Kashani,K.B.
    Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate
    Kidney360 (2023) 4, 673-679. PubMed  Europe PubMed DOI
  9. Bonadio,A., Wenig,B.L., Hockla,A., Radisky,E.S. and Shifman,J.M.
    Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor
    J Mol Biol (2023) 435, 168095-168095. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Coates-Park,S., Lazaroff,C., Gurung,S., Rich,J., Colladay,A., O'Neill,M., Butler,G.S., Overall,C.M., Stetler-Stevenson,W.G. and Peeney,D.
    Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9
    Matrix Biol (2023) 123, 59-70. PubMed  Europe PubMed DOI
  11. Da Silva,J., Freitas,J.R., do Carmo,E.R. and Gomes,J.R.
    MT1-MMP and TIMP-2 are first expressed in the colon glands after a single dose of azoxymethane (AOM)
    Anat Rec (Hoboken) (2023) PubMed  Europe PubMed DOI
  12. Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N.
    Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
    Res Sq (2023) PubMed  Europe PubMed DOI  PMC  EPMC
  13. Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N.
    Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
    Sci Rep (2023) 13, 5186-5186. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Sangwan,P., Quasimi,H., Sharma,J.G., Habib,M.A. and Alam,M.I.
    Role of Oxidative Stress and Genetic Polymorphism of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in COPD
    Chronic Obstr Pulm Dis (2023) PubMed  Europe PubMed DOI  V
  15. Stetler-Stevenson,W.G.
    The Continuing Saga of Tissue Inhibitor of Metalloproteinase 2: Emerging Roles in Tissue Homeostasis and Cancer Progression
    Am J Pathol (2023) 193, 1336-1352. PubMed  Europe PubMed DOI  PMC  EPMC  V
    16. 2022
  16. Li,N., Geng,F., Liang,S.M. and Qin,X.
    USP7 inhibits TIMP2 by up-regulating the expression of EZH2 to activate the NF-kappaB/PD-L1 axis to promote the development of cervical cancer
    Cell Signal (2022) 96, 110351-110351. PubMed  Europe PubMed DOI
  17. Peeney,D., Liu,Y., Lazaroff,C., Gurung,S. and Stetler-Stevenson,W.G.
    Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer
    Carcinogenesis (2022) 43, 405-418. PubMed  Europe PubMed DOI  PMC  EPMC  V
    18. 2021
  18. Dusanovic Pjevic,M., Jekic,B., Beslac Bumbasirevic,L., Vojvodic,L., Damnjanovic,T., Grk,M., Maksimovic,N., Pesic,M., Gulic,M., Trickovic,J. and Kacar,K.
    TT genotype of the MMP-9-1562C/T polymorphism may be a risk factor for thrombolytic therapy-induced hemorrhagic complications after acute ischemic stroke
    Pharmacotherapy (2021) PubMed  Europe PubMed DOI
  19. Esmeijer,K., Schoe,A., Ruhaak,L.R., Hoogeveen,E.K., Soonawala,D., Romijn,F.P.H.T., Shirzada,M.R., van Dissel,J.T., Cobbaert,C.M. and de Fijter,J.W.
    The predictive value of TIMP-2 and IGFBP7 for kidney failure and 30-day mortality after elective cardiac surgery
    Sci Rep (2021) 11, 1071-1071. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Nakagawa,M., Shirasugi,M., Yamamoto,T., Nakaya,T. and Kanamura,N.
    Long-term exposure to butyric acid induces excessive production of matrix metalloproteases in human gingival fibroblasts
    Arch Oral Biol (2021) 123, 105035-105035. PubMed  Europe PubMed DOI  L
  21. Nissi,R., Santala,M. and Talvensaari-Mattila,A.
    The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study
    BMC Res Notes (2021) 14, 31-31. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Sakyi,S.A., Ephraim,R.K.D., Adoba,P., Amoani,B., Buckman,T., Mantey,R. and Eghan,B.A.
    Tissue inhibitor metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) best predicts the development of acute kidney injury
    Heliyon (2021) 7, e07960-e07960. PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2020
  23. Azevedo Martins,J.M., Rabelo-Santos,S.H., do Amaral Westin,M.C. and Zeferino,L.C.
    Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis
    BMC Cancer (2020) 20, 660-660. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Carreca,A.P., Pravata,V.M., Markham,M., Bonelli,S., Murphy,G., Nagase,H., Troeberg,L. and Scilabra,S.D.
    TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1
    Sci Rep (2020) 10, 12067-12067. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Drishya,G., Nambiar,J., Shaji,S.K., Vanuopadath,M., Achuthan,A., Kumar,A., Alias,A., Sherif,A., Joseph,C., Divya,P., Kumar,D.S., Bose,C., Nair,S.V., Sudarslal,S., Kumar,G.B., Lakshmi,S. and Nair,B.G.
    RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata
    J Biosci (2020) 45 PubMed  Europe PubMed
  26. Guo,W., Zhang,B., Sun,C., Duan,H.Q., Liu,W.X., Mu,K., Zhao,L., Li,H.R., Dong,Z.Y. and Cui,Q.
    Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR1855p and matrix metalloproteinase 2
    Int J Mol Med (2020) 46, 621-632. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Han,Z.L., Wang,H.Q., Zhang,T.S., He,Y.X. and Zhou,H.
    Up-regulation of exosomal miR-106a may play a significant role in abdominal aortic aneurysm by inducing vascular smooth muscle cell apoptosis and targeting TIMP-2, an inhibitor of metallopeptidases that suppresses extracellular matrix degradation
    Eur Rev Med Pharmacol Sci (2020) 24, 8087-8095. PubMed  Europe PubMed DOI
  28. Ji,J.J., Qian,L.L., Zhu,Y., Wu,Y.P., Guo,J.Q., Ma,G.S. and Yao,Y.Y.
    Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway
    Cell Signal (2020) 75, 109745-109745. PubMed  Europe PubMed DOI
  29. Kaczorowska,A., Miekus,N., Stefanowicz,J. and Adamkiewicz-Drozynska,E.
    Selected Matrix Metalloproteinases (MMP-2, MMP-7) and Their Inhibitor (TIMP-2) in Adult and Pediatric Cancer
    Diagnostics (Basel) (2020) 10 PubMed  Europe PubMed DOI  V
  30. Ke,X., Zhou,Q., Li,B., Shao,X., Hong,G., Zou,H. and Ling,Y.
    Tissue Inhibitor of Matrix Metalloproteinase 2-Loaded Polylactic Acid-Polyethylene Glycol Nanoparticles Directly Regulates Renal Tubular Epithelial Cell Proliferation via Protein Tyrosine Kinase KIT
    J Nanosci Nanotechnol (2020) 20, 7425-7432. PubMed  Europe PubMed DOI
  31. Vira,H.J., Pradhan,V.D., Umare,V.D., Chaudhary,A.K., Rajadhyksha,A.G., Nadkar,M.Y., Ghosh,K. and Nadkarni,A.H.
    Expression of the matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in systemic lupus erythematosus patients
    Neth J Med (2020) 78, 261-268. PubMed  Europe PubMed
  32. Voitiv,Y., Usenko,O., Dosenko,V., Dyadyk,O. and Dzhemiliev,A.
    ANALYSIS OF POLYMORPHISM OF MATRIX METALLOPROTEINASE-2 (C-1306
    Georgian Med News (2020) , 7-12. PubMed  Europe PubMed
  33. Wang,H., Huang,L., Wu,L., Lan,J., Feng,X., Li,P. and Peng,Y.
    The MMP-2/TIMP-2 system in Alzheimer disease
    CNS Neurol Disord Drug Targets (2020) 19, 402-416. PubMed  Europe PubMed DOI  V
  34. Xue,A., Feng,G., Zhu,C. and Fan,S.
    [Prokaryotic expression, purification and characterization of tissue inhibitor of metalloproteinase-2]
    Sheng Wu Gong Cheng Xue Bao (2020) 36, 2868-2876. PubMed  Europe PubMed DOI  L
  35. Yang,B., Zhang,D., Qian,J. and Cheng,Y.
    Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system
    Mol Cell Biochem (2020) 474, 199-208. PubMed  Europe PubMed DOI
  36. Zhang,Y., Liu,H., Chen,Z., Yu,M., Li,J., Dong,H., Li,N., Ding,X., Ge,Y., Liu,C., Ma,T. and Gui,B.
    TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice
    Neurochem Int (2020) 140, 104818-104818. PubMed  Europe PubMed DOI
    37. 2019
  37. Zhong,C., Cao,M.J., Shu,M., Sun,L.C., Yang,H.H. and Wu,G.P.
    Tissue inhibitor of metalloproteinase-2 (TIMP-2) from red seabream (Pagrus major): molecular cloning and biochemical characterization of highly expressed recombinant protein
    Fish Shellfish Immunol (2019) 95, 556-563. PubMed  Europe PubMed DOI
    38. 2018
  38. Arkadash,V., Radisky,E.S. and Papo,N.
    Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell
    Oncotarget (2018) 9, 32036-32053. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Shirian,J., Arkadash,V., Cohen,I., Sapir,T., Radisky,E.S., Papo,N. and Shifman,J.M.
    Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14
    FEBS Lett (2018) 592, 1122-1134. PubMed  Europe PubMed DOI
    40. 2017
  40. Arkadash,V., Yosef,G., Shirian,J., Cohen,I., Horev,Y., Grossman,M., Sagi,I., Radisky,E.S., Shifman,J.M. and Papo,N.
    Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution
    J Biol Chem (2017) 292, 3481-3495. PubMed  Europe PubMed DOI
  41. Jiang,B., Zhang,Y., Liu,J., Tsigkou,A., Rapti,M. and Lee,M.H.
    Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition
    Oncotarget (2017) 8, 22685-22699. PubMed  Europe PubMed DOI
  42. Xu,P., Guo,W., Jin,T., Wang,J., Fan,D., Hao,Z., Jing,S., Han,C., Du,J., Jiang,D., Wen,S. and Wang,J.
    TIMP-2 SNPs rs7342880 and rs4789936 are linked to risk of knee osteoarthritis in the Chinese Han Population
    Oncotarget (2017) 8, 1166-1176. PubMed  Europe PubMed DOI  M
    43. 2016
  43. Guo,C., Tsigkou,A. and Lee,M.H.
    ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4
    Biomed Rep (2016) 4, 73-78. PubMed  Europe PubMed DOI  PMC  EPMC  I
    44. 2014
  44. Koppisetti,R.K., Fulcher,Y.G., Jurkevich,A., Prior,S.H., Xu,J., Lenoir,M., Overduin,M. and Van Doren,S.R.
    Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12
    Nat Commun (2014) 5, 5552-5552. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Sharabi,O., Shirian,J., Grossman,M., Lebendiker,M., Sagi,I. and Shifman,J.
    Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs
    PLoS ONE (2014) 9, e93712-e93712. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Stetler-Stevenson,W.G. and Gavil,N.V.
    Normalization of the tumor microenvironment: evidence for tissue inhibitor of metalloproteinase-2 as a cancer therapeutic
    Connect Tissue Res (2014) 55, 13-19. PubMed  Europe PubMed DOI  U
  47. Ukaji,T., Sasazawa,Y., Umezawa,K. and Simizu,S.
    Involvement of conserved tryptophan residues for secretion of TIMP-2
    Oncol Lett (2014) 7, 631-634. PubMed  Europe PubMed DOI  PMC  EPMC
    48. 2013
  48. Givvimani,S., Kundu,S., Narayanan,N., Armaghan,F., Qipshidze,N., Pushpakumar,S., Vacek,T.P. and Tyagi,S.C.
    TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV dysfunction and heart failure
    Arch Physiol Biochem (2013) 119, 65-74. PubMed  Europe PubMed DOI  K
  49. Higashi,S., Hirose,T., Takeuchi,T. and Miyazaki,K.
    Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2)
    J Biol Chem (2013) 288, 9066-9076. PubMed  Europe PubMed DOI
  50. Pushpakumar,S., Kundu,S., Pryor,T., Givvimani,S., Lederer,E., Tyagi,S.C. and Sen,U.
    Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice
    J Hypertens (2013) 31, 2270-2281. PubMed  Europe PubMed DOI  K
  51. Takahashi,T., Fujimori,C., Hagiwara,A. and Ogiwara,K.
    Recent advances in the understanding of teleost medaka ovulation: the roles of proteases and prostaglandins
    Zoolog Sci (2013) 30, 239-247. PubMed  Europe PubMed DOI
    52. 2012
  52. Batra,J., Robinson,J., Soares,A.S., Fields,A.P., Radisky,D.C. and Radisky,E.S.
    Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure
    J Biol Chem (2012) 287, 15935-15946. PubMed  Europe PubMed DOI  S
  53. Fu,L., Sun,G., Fiorentino,M. and Shi,Y.B.
    Characterization of Xenopus tissue inhibitor of metalloproteinases-2: a role in regulating matrix metalloproteinase activity during development
    PLoS ONE (2012) 7, e36707-e36707. PubMed  Europe PubMed DOI  PMC  EPMC
  54. Jiang,J., Qian,B., Mao,S., Zhao,Q., Qiu,X., Liu,Z. and Qiu,Y.
    A promoter polymorphism of tissue inhibitor of metalloproteinase-2 gene is associated with severity of thoracic adolescent idiopathic scoliosis
    Spine (Phila Pa 1976) (2012) 37, 41-47. PubMed  Europe PubMed DOI  M
  55. Nieuwesteeg,M.A., Walsh,L.A., Fox,M.A. and Damjanovski,S.
    Domain specific overexpression of TIMP-2 and TIMP-3 reveals MMP-independent functions of TIMPs during Xenopus laevis development
    Biochem Cell Biol (2012) 90, 585-595. PubMed  Europe PubMed DOI
    56. 2011
  56. Bahudhanapati,H., Zhang,Y., Sidhu,S.S. and Brew,K.
    Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): Identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1))
    J Biol Chem (2011) 286, 31761-31770. PubMed  Europe PubMed DOI
  57. Ramani,R., Nilles,K., Gibson,G., Burkhead,B., Mathier,M., McNamara,D. and McTiernan,C.F.
    Tissue inhibitor of metalloproteinase-2 gene delivery ameliorates postinfarction cardiac remodeling
    Clin Transl Sci (2011) 4, 24-31. PubMed  Europe PubMed DOI  U
  58. Xu,X., Mikhailova,M., Chen,Z., Pal,S., Robichaud,T.K., Lafer,E.M., Baber,S. and Steffensen,B.
    Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2)
    Matrix Biol (2011) 30, 404-412. PubMed  Europe PubMed DOI
  59. Xu,X.Y., Shen,Y.B., Yang,X.M. and Li,J.L.
    Cloning and characterization of TIMP-2b gene in grass carp
    Comp Biochem Physiol B Biochem Mol Biol (2011) 159, 115-121. PubMed  Europe PubMed DOI
    60. 2010
  60. Kveiborg,M., Jacobsen,J., Lee,M.H., Nagase,H., Wewer,U.M. and Murphy,G.
    Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)
    Biochem J (2010) 430, 79-86. PubMed  Europe PubMed DOI
  61. Sato,H. and Takino,T.
    Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion
    Cancer Sci (2010) 101, 843-847. PubMed  Europe PubMed DOI  V
  62. Williamson,R.A.
    Refolding of TIMP-2 from Escherichia coli Inclusion Bodies
    Methods Mol Biol (2010) 622, 111-121. PubMed  Europe PubMed DOI  E
    63. 2009
  63. Ledgard,A.M., Lee,R.S. and Peterson,A.J.
    Bovine endometrial legumain and TIMP-2 regulation in response to presence of a conceptus
    Mol Reprod Dev (2009) 76, 65-74. PubMed  Europe PubMed DOI
  64. McNally,L.R., Rosenthal,E.L., Zhang,W. and Buchsbaum,D.J.
    Therapy of head and neck squamous cell carcinoma with replicative adenovirus expressing tissue inhibitor of metalloproteinase-2 and chemoradiation
    Cancer Gene Ther (2009) 16, 246-255. PubMed  Europe PubMed DOI  PMC  EPMC  U
  65. Reuter,B., Bugert,P., Stroick,M., Bukow,S., Griebe,M., Hennerici,M.G. and Fatar,M.
    TIMP-2 gene polymorphism is associated with intracerebral hemorrhage
    Cerebrovasc Dis (2009) 28, 558-563. PubMed  Europe PubMed DOI  M
    66. 2008
  66. D'Alessio,S., Ferrari,G., Cinnante,K., Scheerer,W., Galloway,A.C., Roses,D.F., Rozanov,D.V., Remacle,A.G., Oh,E.S., Shiryaev,S.A., Strongin,A.Y., Pintucci,G. and Mignatti,P.
    Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism
    J Biol Chem (2008) 283, 87-99. PubMed  Europe PubMed DOI
  67. Deng,X., He,G., Levine,A., Cao,Y. and Mullins,C.
    Adenovirus-mediated expression of TIMP-1 and TIMP-2 in bone inhibits osteolytic degradation by human prostate cancer
    Int J Cancer (2008) 122, 209-218. PubMed  Europe PubMed DOI  U
  68. Simeone,A.M., McMurtry,V., Nieves-Alicea,R., Saavedra,J.E., Keefer,L.K., Johnson,M.M. and Tari,A.M.
    TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells
    Breast Cancer Res (2008) 10, R44-R44. PubMed  Europe PubMed DOI  PMC  EPMC
  69. Zhao,X., Li,H., Ji,W., Shi,X. and Dong,J.
    Construction of an adenovirus vector carrying the human tissue inhibitor of metalloproteinase 2 gene
    Biosci Trends (2008) 2, 245-249. PubMed  Europe PubMed  U
    70. 2007
  70. Maskos,K., Lang,R., Tschesche,H. and Bode,W.
    Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2
    J Mol Biol (2007) 366, 1222-1231. PubMed  Europe PubMed DOI  S
  71. Yan,X., Zhao,H., Zhang,W., Xue,C. and Liu,Z.
    Cloning and expressing a recombinant human tissue inhibitor of metalloproteinase-2 (TIMP-2) in methylotrophic yeast Pichia pastoris and its characterizations
    Front Biol China (2007) 2, 170-175. DOI  E
    72. 2006
  72. [YEAR:7-10-2006]Jaworski,D.M., Soloway,P., Caterina,J. and Falls,W.A.
    Tissue inhibitor of metalloproteinase-2(TIMP-2)-deficient mice display motor deficits
    J Neurobiol (7-10-2006) 66, 82-94. PubMed  Europe PubMed DOI  PMC  EPMC  K
  73. [YEAR:11-9-2006]Lluri,G., Langlois,G.D., McClellan,B., Soloway,P.D. and Jaworski,D.M.
    Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism
    J Neurobiol (11-9-2006) 66, 1365-1377. PubMed  Europe PubMed DOI
  74. [YEAR:1-9-2006]Pinto,A.F., Terra,R.M., Guimaraes,J.A., Kashiwagi,M., Nagase,H., Serrano,S.M. and Fox,J.W.
    Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction
    Biochem Biophys Res Commun (1-9-2006) 347, 641-648. PubMed  Europe PubMed DOI
  75. [YEAR:15-6-2006]Rapti,M., Knauper,V., Murphy,G. and Williamson,R.A.
    Characterization of the AB loop region of TIMP-2. Involvement in pro-MMP-2 activation
    J Biol Chem (15-6-2006) 281, 23386-23394. PubMed  Europe PubMed DOI
    76. 2005
  76. [YEAR:23-6-2005]Jaworski,D.M., Boone,J., Caterina,J., Soloway,P. and Falls,W.A.
    Prepulse inhibition and fear-potentiated startle are altered in tissue inhibitor of metalloproteinase-2 (TIMP-2) knockout mice
    Brain Res (23-6-2005) 1051, 81-89. PubMed  Europe PubMed DOI  K
  77. [YEAR:15-11-2005]Lee,Y.K., So,I.S., Lee,S.C., Lee,J.H., Lee,C.W., Kim,W.M., Park,M.K., Lee,S.T., Park,D.Y., Shin,D.Y., Park,C.U. and Kim,Y.S.
    Suppression of distant pulmonary metastasis of MDA-MB 435 human breast carcinoma established in mammary fat pads of nude mice by retroviral-mediated TIMP-2 gene transfer
    J Gene Med (15-11-2005) 7, 145-157. PubMed  Europe PubMed DOI
  78. Miyoshi,H., Kanekura,T., Aoki,T. and Kanzaki,T.
    Beneficial effects of tissue inhibitor of metalloproteinases-2 (TIMP-2) on chronic dermatitis
    J Dermatol (2005) 32, 346-353. PubMed  Europe PubMed
  79. Stetler-Stevenson,W.G. and Seo,D.W.
    TIMP-2: an endogenous inhibitor of angiogenesis
    Trends Mol Med (2005) 11, 97-103. PubMed  Europe PubMed DOI
    80. 2004
  80. [YEAR:12-8-2004]Lee,M.H., Rapti,M. and Murphy,G.
    Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme
    J Biol Chem (12-8-2004) 279, 45121-45129. PubMed  Europe PubMed DOI
  81. Lodemel,J.B., Egge-Jacobsen,W. and Olsen,R.L.
    Detection of TIMP-2-like protein in Atlantic cod (Gadus morhua) muscle using two-dimensional real-time reverse zymography
    Comp Biochem Physiol B Biochem Mol Biol (2004) 139, 253-259. PubMed  Europe PubMed DOI
  82. [YEAR:16-12-2004]Zhao,H., Bernardo,M.M., Osenkowski,P., Sohail,A., Pei,D., Nagase,H., Kashiwagi,M., Soloway,P.D., DeClerck,Y.A. and Fridman,R.
    Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation
    J Biol Chem (16-12-2004) 279, 8592-8601. PubMed  Europe PubMed DOI  I
    83. 2003
  83. [YEAR:1-10-2003]Kubota,S., Kinoshita,M., Uji,S., Yokoyama,Y., Yamamoto,E., Hirono,I., Aoki,T., Sakaguchi,M., Morioka,K., Itoh,Y. and Toyohara,H.
    Occurrence of two distinct types of tissue inhibitor of metalloproteinases-2 in teleost fish
    Biochim Biophys Acta (1-10-2003) 1629, 102-108. PubMed  Europe PubMed DOI
  84. [YEAR:23-10-2003]Lafleur,M.A., Tester,A.M. and Thompson,E.W.
    Selective involvement of TIMP-2 in the second activational cleavage of pro-MMP-2: refinement of the pro-MMP-2 activation mechanism
    FEBS Lett (23-10-2003) 553, 457-463. PubMed  Europe PubMed DOI
  85. [YEAR:15-6-2003]Worley,J.R., Thompkins,P.B., Lee,M.H., Hutton,M., Soloway,P., Edwards,D.R., Murphy,G. and Knauper,V.
    Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP)
    Biochem J (15-6-2003) 372, 799-809. PubMed  Europe PubMed DOI  PMC  EPMC
  86. Zhang,J., Bai,S., Tanase,C., Nagase,H. and Sarras,M.P., Jr.
    The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos
    Dev Genes Evol (2003) 213, 382-389. PubMed  Europe PubMed DOI
    87. 2002
  87. [YEAR:28-5-2002]Morgunova,E., Tuuttila,A., Bergmann,U. and Tryggvason,K.
    Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
    Proc Natl Acad Sci U S A (28-5-2002) 99, 7414-7419. PubMed  Europe PubMed DOI  PMC  EPMC  S
    88. 2001
  88. [YEAR:13-4-2001]Hashimoto,G., Aoki,T., Nakamura,H., Tanzawa,K. and Okada,Y.
    Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)
    FEBS Lett (13-4-2001) 494, 192-195. PubMed  Europe PubMed DOI
  89. [YEAR:31-8-2001]Williamson,R.A., Hutton,M., Vogt,G., Rapti,M., Knauper,V., Carr,M.D. and Murphy,G.
    Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14
    J Biol Chem (31-8-2001) 276, 32966-32970. PubMed  Europe PubMed DOI
    90. 2000
  90. [YEAR:25-8-2000]Caterina,J.J., Yamada,S., Caterina,N.C., Longenecker,G., Holmback,K., Shi,J., Yermovsky,A.E., Engler,J.A. and Birkedal-Hansen,H.
    Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2 (Timp-2) gene alters proMMP-2 activation
    J Biol Chem (25-8-2000) 275, 26416-26422. PubMed  Europe PubMed DOI
  91. [YEAR:29-12-2000]Toth,M., Bernardo,M.M., Gervasi,D.C., Soloway,P.D., Wang,Z., Bigg,H.F., Overall,C.M., DeClerck,Y.A., Tschesche,H., Cher,M.L., Brown,S., Mobashery,S. and Fridman,R.
    Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2
    J Biol Chem (29-12-2000) 275, 41415-41423. PubMed  Europe PubMed DOI
    92. 1999
  92. [YEAR:16-7-1999]Butler,G.S., Hutton,M., Wattam,B.A., Williamson,R.A., Knauper,V., Willenbrock,F. and Murphy,G.
    The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations
    J Biol Chem (16-7-1999) 274, 20391-20396. PubMed  Europe PubMed DOI
  93. [YEAR:12-2-1999]Overall,C.M., King,A.E., Sam,D.K., Ong,A.D., Lau,T.T., Wallon,U.M., DeClerck,Y.A. and Atherstone,J.
    Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin modules III and IV
    J Biol Chem (12-2-1999) 274, 4421-4429. PubMed  Europe PubMed DOI
    94. 1998
  94. [YEAR:9-1-1998]Butler,G.S., Butler,M.J., Atkinson,S.J., Will,H., Tamura,T., Schade van Westrum,S., Crabbe,T., Clements,J., d'Ortho,M.P. and Murphy,G.
    The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study
    J Biol Chem (9-1-1998) 273, 871-880. PubMed  Europe PubMed DOI
  95. [YEAR:15-7-1998]Farina,A.R., Tacconelli,A., Teti,A., Gulino,A. and Mackay,A.R.
    Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate
    Cancer Res (15-7-1998) 58, 2957-2960. PubMed  Europe PubMed
  96. [YEAR:1-9-1998]Fernandez-Catalan,C., Bode,W., Huber,R., Turk,D., Calvete,J.J., Lichte,A., Tschesche,H. and Maskos,K.
    Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor
    EMBO J (1-9-1998) 17, 5238-5248. PubMed  Europe PubMed DOI  PMC  EPMC  S
  97. [YEAR:14-7-1998]Hutton,M., Willenbrock,F., Brocklehurst,K. and Murphy,G.
    Kinetic analysis of the mechanism of interaction of full-length TIMP-2 and gelatinase A: Evidence for the existence of a low-affinity intermediate
    Biochemistry (14-7-1998) 37, 10094-10098. PubMed  Europe PubMed DOI
  98. [YEAR:18-9-1998]Itoh,Y., Ito,A., Iwata,K., Tanzawa,K., Mori,Y. and Nagase,H.
    Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface
    J Biol Chem (18-9-1998) 273, 24360-24367. PubMed  Europe PubMed DOI
  99. Muskett,F.W., Frenkiel,T.A., Feeney,J., Freedman,R.B., Carr,M.D. and Williamson,R.A.
    High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3
    J Biol Chem (1998) 273, 21736-21743. PubMed  Europe PubMed DOI  S
  100. [YEAR:11-12-1998]Tuuttila,A., Morgunova,E., Bergmann,U., Lindqvist,Y., Maskos,K., Fernandez-Catalan,C., Bode,W., Tryggvason,K. and Schneider,G.
    Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution
    J Mol Biol (11-12-1998) 284, 1133-1140. PubMed  Europe PubMed DOI  S
    101. 1997
  101. Gomez,D.E., Alonso,D.F., Yoshiji,H. and Thorgeirsson,U.P.
    Tissue inhibitors of metalloproteinases: structure, regulation and biological functions
    Eur J Cell Biol (1997) 74, 111-122. PubMed  Europe PubMed
    102. 1996
  102. [YEAR:9-9-1996]Sato,H., Kinoshita,T., Takino,T., Nakayama,K. and Seiki,M.
    Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2
    FEBS Lett (9-9-1996) 393, 101-104. PubMed  Europe PubMed DOI
    103. 1995
  103. [YEAR:1-6-1995]Itoh,Y., Binner,S. and Nagase,H.
    Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate
    Biochem J (1-6-1995) 308, 645-651. PubMed  Europe PubMed  PMC  EPMC
  104. Murphy,G. and Willenbrock,F.
    Tissue inhibitors of matrix metalloendopeptidases
    Methods Enzymol (1995) 248, 496-510. PubMed  Europe PubMed DOI  V
    105. 1994
  105. De Clerck,Y.A., Darville,M.I., Eeckhout,Y. and Rousseau,G.G.
    Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2)
    Gene (1994) 139, 185-191. PubMed  Europe PubMed DOI
  106. Williamson,R.A., Bartels,H., Murphy,G. and Freedman,R.B.
    Folding and stability of the active N-terminal domain of tissue inhibitor of metalloproteinases-1 and -2
    Protein Eng (1994) 7, 1035-1040. PubMed  Europe PubMed
  107. [YEAR:4-10-1994]Williamson,R.A., Martorell,G., Carr,M.D., Murphy,G., Docherty,A.J., Freedman,R.B. and Feeney,J.
    Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family
    Biochemistry (4-10-1994) 33, 11745-11759. PubMed  Europe PubMed DOI  S
    108. 1993
  108. Fridman,R., Bird,R.E., Hoyhtya,M., Oelkuct,M., Komarek,D., Liang,C.M., Berman,M.L., Liotta,L.A., Stetler-Stevenson,W.G. and Fuerst,T.R.
    Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme
    Biochem J (1993) 289, 411-416. PubMed  Europe PubMed  PMC  EPMC  E
  109. Hill,P.A., Reynolds,J.J. and Meikle,M.C.
    Inhibition of stimulated bone resorption in vitro by TIMP- 1 and TIMP-2
    Biochim Biophys Acta (1993) 1177, 71-74. PubMed  Europe PubMed DOI
  110. [YEAR:27-4-1993]Willenbrock,F., Crabbe,T., Slocombe,P.M., Sutton,C.W., Docherty,A.J., Cockett,M.I., O'Shea,M., Brocklehurst,K., Phillips,I.R. and Murphy,G.
    The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A
    Biochemistry (27-4-1993) 32, 4330-4337. PubMed  Europe PubMed
    111. 1992
  111. Kleiner,D.E., Jr., Unsworth,E.J., Krutzsch,H.C. and Stetler-Stevenson,W.G.
    Higher-order complex formation between the 72-kilodalton type IV collagenase and tissue inhibitor of metalloproteinases- 2
    Biochemistry (1992) 31, 1665-1672. PubMed  Europe PubMed
  112. Roswit,W.T., McCourt,D.W., Partridge,N.C. and Jeffrey,J.J.
    Purification and sequence analysis of two rat tissue inhibitors of metalloproteinases
    Arch Biochem Biophys (1992) 292, 402-410. PubMed  Europe PubMed DOI
    113. 1991
  113. Howard,E.W. and Banda,M.J.
    Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site
    J Biol Chem (1991) 266, 17972-17977. PubMed  Europe PubMed
  114. Kolkenbrock,H., Orgel,D., Hecker-Kia,A., Noack,W. and Ulbrich,N.
    The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor
    Eur J Biochem (1991) 198, 775-781. PubMed  Europe PubMed
  115. Ward,R.V., Hembry,R.M., Reynolds,J.J. and Murphy,G.
    The purification of tissue inhibitor of metalloproteinases- 2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases- 2 and tissue inhibitor of metalloproteinases-1
    Biochem J (1991) 278, 179-187. PubMed  Europe PubMed  PMC  EPMC
    116. 1989
  116. [YEAR:15-10-1989]Stetler-Stevenson,W.G., Krutzsch,H.C. and Liotta,L.A.
    Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family
    J Biol Chem (15-10-1989) 264, 17374-17378. PubMed  Europe PubMed

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