Literature for inhibitor I35.002: timp-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Lin,X., Chen,Y., Zhong,B. and Yu,H. Cathepsin K and glycosaminoglycans differentially regulate matrix metalloproteinase activity in dentin under various pH conditions Int J Biol Macromol (2025) 327, 147486-147486. PubMed Europe PubMed DOI L

2024

Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E. Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target Basic Clin Pharmacol Toxicol (2024) 134, 727-736. PubMed Europe PubMed DOI L
Delrue,C. and Speeckaert,M.M. Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) as a Prognostic Biomarker in Acute Kidney Injury: A Narrative Review Diagnostics (Basel) (2024) 14 PubMed Europe PubMed DOI PMC EPMC V
Gowtham,P., Girigoswami,K., Thirumalai,A., Harini,K., Pallavi,P. and Girigoswami,A. Association of TIMP2 418 G/C and MMP Gene Polymorphism with Risk of Urinary Cancers: Systematic Review and Meta-analysis Genet Test Mol Biomarkers (2024) 28, 83-90. PubMed Europe PubMed DOI
Leng,J., Li,L., Tu,H., Luo,Y., Cao,Z., Zhou,K., Rizvi,S.M.M., Tie,H. and Jiang,Y. Mechanism and clinical role of TIMP-2 and IGFBP-7 in cardiac surgery-associated acute kidney injury: A review Medicine (Baltimore) (2024) 103, e38124-e38124. PubMed Europe PubMed DOI PMC EPMC
Rotenberg,N., Feldman,M., Shirian,J., Hockla,A., Radisky,E.S. and Shifman,J.M. Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple negative breast cancer cells J Biol Chem (2024) , 107867-107867. PubMed Europe PubMed DOI

2023

Abouhadid,M.A., Gawad,T.A.A., Gebaly,H.H.E., Abdallah,A.A., Refay,A.S.E., Helmy,N.M. and Allam,A.M. Urinary tissue inhibitor of metalloproteinase-2 as an early predictor for acute kidney injury in critically ill children Int J Health Sci (Qassim) (2023) 17, 22-28. PubMed Europe PubMed PMC EPMC
Barreto,J.N., Barreto,E.F., Mara,K.C., Rule,A.D., Lieske,J.C., Giesen,C.D., Thompson,C.A., Leung,N., Witzig,T.E. and Kashani,K.B. Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate Kidney360 (2023) 4, 673-679. PubMed Europe PubMed DOI
Bonadio,A., Wenig,B.L., Hockla,A., Radisky,E.S. and Shifman,J.M. Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor J Mol Biol (2023) 435, 168095-168095. PubMed Europe PubMed DOI PMC EPMC
Coates-Park,S., Lazaroff,C., Gurung,S., Rich,J., Colladay,A., O'Neill,M., Butler,G.S., Overall,C.M., Stetler-Stevenson,W.G. and Peeney,D. Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9 Matrix Biol (2023) 123, 59-70. PubMed Europe PubMed DOI
Da Silva,J., Freitas,J.R., do Carmo,E.R. and Gomes,J.R. MT1-MMP and TIMP-2 are first expressed in the colon glands after a single dose of azoxymethane (AOM) Anat Rec (Hoboken) (2023) PubMed Europe PubMed DOI
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N. Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14 Res Sq (2023) PubMed Europe PubMed DOI PMC EPMC
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N. Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14 Sci Rep (2023) 13, 5186-5186. PubMed Europe PubMed DOI PMC EPMC
Sangwan,P., Quasimi,H., Sharma,J.G., Habib,M.A. and Alam,M.I. Role of Oxidative Stress and Genetic Polymorphism of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in COPD Chronic Obstr Pulm Dis (2023) PubMed Europe PubMed DOI V
Stetler-Stevenson,W.G. The Continuing Saga of Tissue Inhibitor of Metalloproteinase 2: Emerging Roles in Tissue Homeostasis and Cancer Progression Am J Pathol (2023) 193, 1336-1352. PubMed Europe PubMed DOI PMC EPMC V

2022

Li,N., Geng,F., Liang,S.M. and Qin,X. USP7 inhibits TIMP2 by up-regulating the expression of EZH2 to activate the NF-kappaB/PD-L1 axis to promote the development of cervical cancer Cell Signal (2022) 96, 110351-110351. PubMed Europe PubMed DOI
Peeney,D., Liu,Y., Lazaroff,C., Gurung,S. and Stetler-Stevenson,W.G. Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer Carcinogenesis (2022) 43, 405-418. PubMed Europe PubMed DOI PMC EPMC V

2021

Dusanovic Pjevic,M., Jekic,B., Beslac Bumbasirevic,L., Vojvodic,L., Damnjanovic,T., Grk,M., Maksimovic,N., Pesic,M., Gulic,M., Trickovic,J. and Kacar,K. TT genotype of the MMP-9-1562C/T polymorphism may be a risk factor for thrombolytic therapy-induced hemorrhagic complications after acute ischemic stroke Pharmacotherapy (2021) PubMed Europe PubMed DOI
Esmeijer,K., Schoe,A., Ruhaak,L.R., Hoogeveen,E.K., Soonawala,D., Romijn,F.P.H.T., Shirzada,M.R., van Dissel,J.T., Cobbaert,C.M. and de Fijter,J.W. The predictive value of TIMP-2 and IGFBP7 for kidney failure and 30-day mortality after elective cardiac surgery Sci Rep (2021) 11, 1071-1071. PubMed Europe PubMed DOI PMC EPMC
Nakagawa,M., Shirasugi,M., Yamamoto,T., Nakaya,T. and Kanamura,N. Long-term exposure to butyric acid induces excessive production of matrix metalloproteases in human gingival fibroblasts Arch Oral Biol (2021) 123, 105035-105035. PubMed Europe PubMed DOI L
Nissi,R., Santala,M. and Talvensaari-Mattila,A. The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study BMC Res Notes (2021) 14, 31-31. PubMed Europe PubMed DOI PMC EPMC
Sakyi,S.A., Ephraim,R.K.D., Adoba,P., Amoani,B., Buckman,T., Mantey,R. and Eghan,B.A. Tissue inhibitor metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) best predicts the development of acute kidney injury Heliyon (2021) 7, e07960-e07960. PubMed Europe PubMed DOI PMC EPMC

2020

Azevedo Martins,J.M., Rabelo-Santos,S.H., do Amaral Westin,M.C. and Zeferino,L.C. Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis BMC Cancer (2020) 20, 660-660. PubMed Europe PubMed DOI PMC EPMC
Carreca,A.P., Pravata,V.M., Markham,M., Bonelli,S., Murphy,G., Nagase,H., Troeberg,L. and Scilabra,S.D. TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1 Sci Rep (2020) 10, 12067-12067. PubMed Europe PubMed DOI PMC EPMC
Drishya,G., Nambiar,J., Shaji,S.K., Vanuopadath,M., Achuthan,A., Kumar,A., Alias,A., Sherif,A., Joseph,C., Divya,P., Kumar,D.S., Bose,C., Nair,S.V., Sudarslal,S., Kumar,G.B., Lakshmi,S. and Nair,B.G. RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata J Biosci (2020) 45 PubMed Europe PubMed
Guo,W., Zhang,B., Sun,C., Duan,H.Q., Liu,W.X., Mu,K., Zhao,L., Li,H.R., Dong,Z.Y. and Cui,Q. Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR1855p and matrix metalloproteinase 2 Int J Mol Med (2020) 46, 621-632. PubMed Europe PubMed DOI PMC EPMC
Han,Z.L., Wang,H.Q., Zhang,T.S., He,Y.X. and Zhou,H. Up-regulation of exosomal miR-106a may play a significant role in abdominal aortic aneurysm by inducing vascular smooth muscle cell apoptosis and targeting TIMP-2, an inhibitor of metallopeptidases that suppresses extracellular matrix degradation Eur Rev Med Pharmacol Sci (2020) 24, 8087-8095. PubMed Europe PubMed DOI
Ji,J.J., Qian,L.L., Zhu,Y., Wu,Y.P., Guo,J.Q., Ma,G.S. and Yao,Y.Y. Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway Cell Signal (2020) 75, 109745-109745. PubMed Europe PubMed DOI
Kaczorowska,A., Miekus,N., Stefanowicz,J. and Adamkiewicz-Drozynska,E. Selected Matrix Metalloproteinases (MMP-2, MMP-7) and Their Inhibitor (TIMP-2) in Adult and Pediatric Cancer Diagnostics (Basel) (2020) 10 PubMed Europe PubMed DOI V
Ke,X., Zhou,Q., Li,B., Shao,X., Hong,G., Zou,H. and Ling,Y. Tissue Inhibitor of Matrix Metalloproteinase 2-Loaded Polylactic Acid-Polyethylene Glycol Nanoparticles Directly Regulates Renal Tubular Epithelial Cell Proliferation via Protein Tyrosine Kinase KIT J Nanosci Nanotechnol (2020) 20, 7425-7432. PubMed Europe PubMed DOI
Vira,H.J., Pradhan,V.D., Umare,V.D., Chaudhary,A.K., Rajadhyksha,A.G., Nadkar,M.Y., Ghosh,K. and Nadkarni,A.H. Expression of the matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in systemic lupus erythematosus patients Neth J Med (2020) 78, 261-268. PubMed Europe PubMed
Voitiv,Y., Usenko,O., Dosenko,V., Dyadyk,O. and Dzhemiliev,A. ANALYSIS OF POLYMORPHISM OF MATRIX METALLOPROTEINASE-2 (C-1306 Georgian Med News (2020) , 7-12. PubMed Europe PubMed
Wang,H., Huang,L., Wu,L., Lan,J., Feng,X., Li,P. and Peng,Y. The MMP-2/TIMP-2 system in Alzheimer disease CNS Neurol Disord Drug Targets (2020) 19, 402-416. PubMed Europe PubMed DOI V
Xue,A., Feng,G., Zhu,C. and Fan,S. [Prokaryotic expression, purification and characterization of tissue inhibitor of metalloproteinase-2] Sheng Wu Gong Cheng Xue Bao (2020) 36, 2868-2876. PubMed Europe PubMed DOI L
Yang,B., Zhang,D., Qian,J. and Cheng,Y. Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system Mol Cell Biochem (2020) 474, 199-208. PubMed Europe PubMed DOI
Zhang,Y., Liu,H., Chen,Z., Yu,M., Li,J., Dong,H., Li,N., Ding,X., Ge,Y., Liu,C., Ma,T. and Gui,B. TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice Neurochem Int (2020) 140, 104818-104818. PubMed Europe PubMed DOI

2019

Zhong,C., Cao,M.J., Shu,M., Sun,L.C., Yang,H.H. and Wu,G.P. Tissue inhibitor of metalloproteinase-2 (TIMP-2) from red seabream (Pagrus major): molecular cloning and biochemical characterization of highly expressed recombinant protein Fish Shellfish Immunol (2019) 95, 556-563. PubMed Europe PubMed DOI

2018

Arkadash,V., Radisky,E.S. and Papo,N. Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell Oncotarget (2018) 9, 32036-32053. PubMed Europe PubMed DOI PMC EPMC
Shirian,J., Arkadash,V., Cohen,I., Sapir,T., Radisky,E.S., Papo,N. and Shifman,J.M. Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14 FEBS Lett (2018) 592, 1122-1134. PubMed Europe PubMed DOI

2017

Arkadash,V., Yosef,G., Shirian,J., Cohen,I., Horev,Y., Grossman,M., Sagi,I., Radisky,E.S., Shifman,J.M. and Papo,N. Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution J Biol Chem (2017) 292, 3481-3495. PubMed Europe PubMed DOI
Jiang,B., Zhang,Y., Liu,J., Tsigkou,A., Rapti,M. and Lee,M.H. Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition Oncotarget (2017) 8, 22685-22699. PubMed Europe PubMed DOI
Xu,P., Guo,W., Jin,T., Wang,J., Fan,D., Hao,Z., Jing,S., Han,C., Du,J., Jiang,D., Wen,S. and Wang,J. TIMP-2 SNPs rs7342880 and rs4789936 are linked to risk of knee osteoarthritis in the Chinese Han Population Oncotarget (2017) 8, 1166-1176. PubMed Europe PubMed DOI M

2016

Guo,C., Tsigkou,A. and Lee,M.H. ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4 Biomed Rep (2016) 4, 73-78. PubMed Europe PubMed DOI PMC EPMC I

2014

Koppisetti,R.K., Fulcher,Y.G., Jurkevich,A., Prior,S.H., Xu,J., Lenoir,M., Overduin,M. and Van Doren,S.R. Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12 Nat Commun (2014) 5, 5552-5552. PubMed Europe PubMed DOI PMC EPMC
Sharabi,O., Shirian,J., Grossman,M., Lebendiker,M., Sagi,I. and Shifman,J. Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs PLoS ONE (2014) 9, e93712-e93712. PubMed Europe PubMed DOI PMC EPMC
Stetler-Stevenson,W.G. and Gavil,N.V. Normalization of the tumor microenvironment: evidence for tissue inhibitor of metalloproteinase-2 as a cancer therapeutic Connect Tissue Res (2014) 55, 13-19. PubMed Europe PubMed DOI U
Ukaji,T., Sasazawa,Y., Umezawa,K. and Simizu,S. Involvement of conserved tryptophan residues for secretion of TIMP-2 Oncol Lett (2014) 7, 631-634. PubMed Europe PubMed DOI PMC EPMC

2013

Givvimani,S., Kundu,S., Narayanan,N., Armaghan,F., Qipshidze,N., Pushpakumar,S., Vacek,T.P. and Tyagi,S.C. TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV dysfunction and heart failure Arch Physiol Biochem (2013) 119, 65-74. PubMed Europe PubMed DOI K
Higashi,S., Hirose,T., Takeuchi,T. and Miyazaki,K. Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2) J Biol Chem (2013) 288, 9066-9076. PubMed Europe PubMed DOI
Pushpakumar,S., Kundu,S., Pryor,T., Givvimani,S., Lederer,E., Tyagi,S.C. and Sen,U. Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice J Hypertens (2013) 31, 2270-2281. PubMed Europe PubMed DOI K
Takahashi,T., Fujimori,C., Hagiwara,A. and Ogiwara,K. Recent advances in the understanding of teleost medaka ovulation: the roles of proteases and prostaglandins Zoolog Sci (2013) 30, 239-247. PubMed Europe PubMed DOI

2012

Batra,J., Robinson,J., Soares,A.S., Fields,A.P., Radisky,D.C. and Radisky,E.S. Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure J Biol Chem (2012) 287, 15935-15946. PubMed Europe PubMed DOI S
Fu,L., Sun,G., Fiorentino,M. and Shi,Y.B. Characterization of Xenopus tissue inhibitor of metalloproteinases-2: a role in regulating matrix metalloproteinase activity during development PLoS ONE (2012) 7, e36707-e36707. PubMed Europe PubMed DOI PMC EPMC
Jiang,J., Qian,B., Mao,S., Zhao,Q., Qiu,X., Liu,Z. and Qiu,Y. A promoter polymorphism of tissue inhibitor of metalloproteinase-2 gene is associated with severity of thoracic adolescent idiopathic scoliosis Spine (Phila Pa 1976) (2012) 37, 41-47. PubMed Europe PubMed DOI M
Nieuwesteeg,M.A., Walsh,L.A., Fox,M.A. and Damjanovski,S. Domain specific overexpression of TIMP-2 and TIMP-3 reveals MMP-independent functions of TIMPs during Xenopus laevis development Biochem Cell Biol (2012) 90, 585-595. PubMed Europe PubMed DOI

2011

Bahudhanapati,H., Zhang,Y., Sidhu,S.S. and Brew,K. Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): Identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1)) J Biol Chem (2011) 286, 31761-31770. PubMed Europe PubMed DOI
Ramani,R., Nilles,K., Gibson,G., Burkhead,B., Mathier,M., McNamara,D. and McTiernan,C.F. Tissue inhibitor of metalloproteinase-2 gene delivery ameliorates postinfarction cardiac remodeling Clin Transl Sci (2011) 4, 24-31. PubMed Europe PubMed DOI U
Xu,X., Mikhailova,M., Chen,Z., Pal,S., Robichaud,T.K., Lafer,E.M., Baber,S. and Steffensen,B. Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2) Matrix Biol (2011) 30, 404-412. PubMed Europe PubMed DOI
Xu,X.Y., Shen,Y.B., Yang,X.M. and Li,J.L. Cloning and characterization of TIMP-2b gene in grass carp Comp Biochem Physiol B Biochem Mol Biol (2011) 159, 115-121. PubMed Europe PubMed DOI

2010

Kveiborg,M., Jacobsen,J., Lee,M.H., Nagase,H., Wewer,U.M. and Murphy,G. Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2) Biochem J (2010) 430, 79-86. PubMed Europe PubMed DOI
Sato,H. and Takino,T. Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion Cancer Sci (2010) 101, 843-847. PubMed Europe PubMed DOI V
Williamson,R.A. Refolding of TIMP-2 from Escherichia coli Inclusion Bodies Methods Mol Biol (2010) 622, 111-121. PubMed Europe PubMed DOI E

2009

Ledgard,A.M., Lee,R.S. and Peterson,A.J. Bovine endometrial legumain and TIMP-2 regulation in response to presence of a conceptus Mol Reprod Dev (2009) 76, 65-74. PubMed Europe PubMed DOI
McNally,L.R., Rosenthal,E.L., Zhang,W. and Buchsbaum,D.J. Therapy of head and neck squamous cell carcinoma with replicative adenovirus expressing tissue inhibitor of metalloproteinase-2 and chemoradiation Cancer Gene Ther (2009) 16, 246-255. PubMed Europe PubMed DOI PMC EPMC U
Reuter,B., Bugert,P., Stroick,M., Bukow,S., Griebe,M., Hennerici,M.G. and Fatar,M. TIMP-2 gene polymorphism is associated with intracerebral hemorrhage Cerebrovasc Dis (2009) 28, 558-563. PubMed Europe PubMed DOI M

2008

D'Alessio,S., Ferrari,G., Cinnante,K., Scheerer,W., Galloway,A.C., Roses,D.F., Rozanov,D.V., Remacle,A.G., Oh,E.S., Shiryaev,S.A., Strongin,A.Y., Pintucci,G. and Mignatti,P. Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism J Biol Chem (2008) 283, 87-99. PubMed Europe PubMed DOI
Deng,X., He,G., Levine,A., Cao,Y. and Mullins,C. Adenovirus-mediated expression of TIMP-1 and TIMP-2 in bone inhibits osteolytic degradation by human prostate cancer Int J Cancer (2008) 122, 209-218. PubMed Europe PubMed DOI U
Simeone,A.M., McMurtry,V., Nieves-Alicea,R., Saavedra,J.E., Keefer,L.K., Johnson,M.M. and Tari,A.M. TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells Breast Cancer Res (2008) 10, R44-R44. PubMed Europe PubMed DOI PMC EPMC
Zhao,X., Li,H., Ji,W., Shi,X. and Dong,J. Construction of an adenovirus vector carrying the human tissue inhibitor of metalloproteinase 2 gene Biosci Trends (2008) 2, 245-249. PubMed Europe PubMed U

2007

Maskos,K., Lang,R., Tschesche,H. and Bode,W. Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2 J Mol Biol (2007) 366, 1222-1231. PubMed Europe PubMed DOI S
Yan,X., Zhao,H., Zhang,W., Xue,C. and Liu,Z. Cloning and expressing a recombinant human tissue inhibitor of metalloproteinase-2 (TIMP-2) in methylotrophic yeast Pichia pastoris and its characterizations Front Biol China (2007) 2, 170-175. DOI E

2006

[YEAR:7-10-2006]Jaworski,D.M., Soloway,P., Caterina,J. and Falls,W.A. Tissue inhibitor of metalloproteinase-2(TIMP-2)-deficient mice display motor deficits J Neurobiol (7-10-2006) 66, 82-94. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:11-9-2006]Lluri,G., Langlois,G.D., McClellan,B., Soloway,P.D. and Jaworski,D.M. Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism J Neurobiol (11-9-2006) 66, 1365-1377. PubMed Europe PubMed DOI
[YEAR:1-9-2006]Pinto,A.F., Terra,R.M., Guimaraes,J.A., Kashiwagi,M., Nagase,H., Serrano,S.M. and Fox,J.W. Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction Biochem Biophys Res Commun (1-9-2006) 347, 641-648. PubMed Europe PubMed DOI
[YEAR:15-6-2006]Rapti,M., Knauper,V., Murphy,G. and Williamson,R.A. Characterization of the AB loop region of TIMP-2. Involvement in pro-MMP-2 activation J Biol Chem (15-6-2006) 281, 23386-23394. PubMed Europe PubMed DOI

2005

[YEAR:23-6-2005]Jaworski,D.M., Boone,J., Caterina,J., Soloway,P. and Falls,W.A. Prepulse inhibition and fear-potentiated startle are altered in tissue inhibitor of metalloproteinase-2 (TIMP-2) knockout mice Brain Res (23-6-2005) 1051, 81-89. PubMed Europe PubMed DOI K
[YEAR:15-11-2005]Lee,Y.K., So,I.S., Lee,S.C., Lee,J.H., Lee,C.W., Kim,W.M., Park,M.K., Lee,S.T., Park,D.Y., Shin,D.Y., Park,C.U. and Kim,Y.S. Suppression of distant pulmonary metastasis of MDA-MB 435 human breast carcinoma established in mammary fat pads of nude mice by retroviral-mediated TIMP-2 gene transfer J Gene Med (15-11-2005) 7, 145-157. PubMed Europe PubMed DOI
Miyoshi,H., Kanekura,T., Aoki,T. and Kanzaki,T. Beneficial effects of tissue inhibitor of metalloproteinases-2 (TIMP-2) on chronic dermatitis J Dermatol (2005) 32, 346-353. PubMed Europe PubMed
Stetler-Stevenson,W.G. and Seo,D.W. TIMP-2: an endogenous inhibitor of angiogenesis Trends Mol Med (2005) 11, 97-103. PubMed Europe PubMed DOI

2004

[YEAR:12-8-2004]Lee,M.H., Rapti,M. and Murphy,G. Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme J Biol Chem (12-8-2004) 279, 45121-45129. PubMed Europe PubMed DOI
Lodemel,J.B., Egge-Jacobsen,W. and Olsen,R.L. Detection of TIMP-2-like protein in Atlantic cod (Gadus morhua) muscle using two-dimensional real-time reverse zymography Comp Biochem Physiol B Biochem Mol Biol (2004) 139, 253-259. PubMed Europe PubMed DOI
[YEAR:16-12-2004]Zhao,H., Bernardo,M.M., Osenkowski,P., Sohail,A., Pei,D., Nagase,H., Kashiwagi,M., Soloway,P.D., DeClerck,Y.A. and Fridman,R. Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation J Biol Chem (16-12-2004) 279, 8592-8601. PubMed Europe PubMed DOI I

2003

[YEAR:1-10-2003]Kubota,S., Kinoshita,M., Uji,S., Yokoyama,Y., Yamamoto,E., Hirono,I., Aoki,T., Sakaguchi,M., Morioka,K., Itoh,Y. and Toyohara,H. Occurrence of two distinct types of tissue inhibitor of metalloproteinases-2 in teleost fish Biochim Biophys Acta (1-10-2003) 1629, 102-108. PubMed Europe PubMed DOI
[YEAR:23-10-2003]Lafleur,M.A., Tester,A.M. and Thompson,E.W. Selective involvement of TIMP-2 in the second activational cleavage of pro-MMP-2: refinement of the pro-MMP-2 activation mechanism FEBS Lett (23-10-2003) 553, 457-463. PubMed Europe PubMed DOI
[YEAR:15-6-2003]Worley,J.R., Thompkins,P.B., Lee,M.H., Hutton,M., Soloway,P., Edwards,D.R., Murphy,G. and Knauper,V. Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP) Biochem J (15-6-2003) 372, 799-809. PubMed Europe PubMed DOI PMC EPMC
Zhang,J., Bai,S., Tanase,C., Nagase,H. and Sarras,M.P., Jr. The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos Dev Genes Evol (2003) 213, 382-389. PubMed Europe PubMed DOI

2002

[YEAR:28-5-2002]Morgunova,E., Tuuttila,A., Bergmann,U. and Tryggvason,K. Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2 Proc Natl Acad Sci U S A (28-5-2002) 99, 7414-7419. PubMed Europe PubMed DOI PMC EPMC S

2001

[YEAR:13-4-2001]Hashimoto,G., Aoki,T., Nakamura,H., Tanzawa,K. and Okada,Y. Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4) FEBS Lett (13-4-2001) 494, 192-195. PubMed Europe PubMed DOI
[YEAR:31-8-2001]Williamson,R.A., Hutton,M., Vogt,G., Rapti,M., Knauper,V., Carr,M.D. and Murphy,G. Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14 J Biol Chem (31-8-2001) 276, 32966-32970. PubMed Europe PubMed DOI

2000

[YEAR:25-8-2000]Caterina,J.J., Yamada,S., Caterina,N.C., Longenecker,G., Holmback,K., Shi,J., Yermovsky,A.E., Engler,J.A. and Birkedal-Hansen,H. Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2 (Timp-2) gene alters proMMP-2 activation J Biol Chem (25-8-2000) 275, 26416-26422. PubMed Europe PubMed DOI
[YEAR:29-12-2000]Toth,M., Bernardo,M.M., Gervasi,D.C., Soloway,P.D., Wang,Z., Bigg,H.F., Overall,C.M., DeClerck,Y.A., Tschesche,H., Cher,M.L., Brown,S., Mobashery,S. and Fridman,R. Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2 J Biol Chem (29-12-2000) 275, 41415-41423. PubMed Europe PubMed DOI

1999

[YEAR:16-7-1999]Butler,G.S., Hutton,M., Wattam,B.A., Williamson,R.A., Knauper,V., Willenbrock,F. and Murphy,G. The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations J Biol Chem (16-7-1999) 274, 20391-20396. PubMed Europe PubMed DOI
[YEAR:12-2-1999]Overall,C.M., King,A.E., Sam,D.K., Ong,A.D., Lau,T.T., Wallon,U.M., DeClerck,Y.A. and Atherstone,J. Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin modules III and IV J Biol Chem (12-2-1999) 274, 4421-4429. PubMed Europe PubMed DOI

1998

[YEAR:9-1-1998]Butler,G.S., Butler,M.J., Atkinson,S.J., Will,H., Tamura,T., Schade van Westrum,S., Crabbe,T., Clements,J., d'Ortho,M.P. and Murphy,G. The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study J Biol Chem (9-1-1998) 273, 871-880. PubMed Europe PubMed DOI
[YEAR:15-7-1998]Farina,A.R., Tacconelli,A., Teti,A., Gulino,A. and Mackay,A.R. Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate Cancer Res (15-7-1998) 58, 2957-2960. PubMed Europe PubMed
[YEAR:1-9-1998]Fernandez-Catalan,C., Bode,W., Huber,R., Turk,D., Calvete,J.J., Lichte,A., Tschesche,H. and Maskos,K. Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor EMBO J (1-9-1998) 17, 5238-5248. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:14-7-1998]Hutton,M., Willenbrock,F., Brocklehurst,K. and Murphy,G. Kinetic analysis of the mechanism of interaction of full-length TIMP-2 and gelatinase A: Evidence for the existence of a low-affinity intermediate Biochemistry (14-7-1998) 37, 10094-10098. PubMed Europe PubMed DOI
[YEAR:18-9-1998]Itoh,Y., Ito,A., Iwata,K., Tanzawa,K., Mori,Y. and Nagase,H. Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface J Biol Chem (18-9-1998) 273, 24360-24367. PubMed Europe PubMed DOI
Muskett,F.W., Frenkiel,T.A., Feeney,J., Freedman,R.B., Carr,M.D. and Williamson,R.A. High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3 J Biol Chem (1998) 273, 21736-21743. PubMed Europe PubMed DOI S
[YEAR:11-12-1998]Tuuttila,A., Morgunova,E., Bergmann,U., Lindqvist,Y., Maskos,K., Fernandez-Catalan,C., Bode,W., Tryggvason,K. and Schneider,G. Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution J Mol Biol (11-12-1998) 284, 1133-1140. PubMed Europe PubMed DOI S

1997

Gomez,D.E., Alonso,D.F., Yoshiji,H. and Thorgeirsson,U.P. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions Eur J Cell Biol (1997) 74, 111-122. PubMed Europe PubMed

1996

[YEAR:9-9-1996]Sato,H., Kinoshita,T., Takino,T., Nakayama,K. and Seiki,M. Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2 FEBS Lett (9-9-1996) 393, 101-104. PubMed Europe PubMed DOI

1995

[YEAR:1-6-1995]Itoh,Y., Binner,S. and Nagase,H. Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate Biochem J (1-6-1995) 308, 645-651. PubMed Europe PubMed PMC EPMC
Murphy,G. and Willenbrock,F. Tissue inhibitors of matrix metalloendopeptidases Methods Enzymol (1995) 248, 496-510. PubMed Europe PubMed DOI V

1994

De Clerck,Y.A., Darville,M.I., Eeckhout,Y. and Rousseau,G.G. Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2) Gene (1994) 139, 185-191. PubMed Europe PubMed DOI
Williamson,R.A., Bartels,H., Murphy,G. and Freedman,R.B. Folding and stability of the active N-terminal domain of tissue inhibitor of metalloproteinases-1 and -2 Protein Eng (1994) 7, 1035-1040. PubMed Europe PubMed
[YEAR:4-10-1994]Williamson,R.A., Martorell,G., Carr,M.D., Murphy,G., Docherty,A.J., Freedman,R.B. and Feeney,J. Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family Biochemistry (4-10-1994) 33, 11745-11759. PubMed Europe PubMed DOI S

1993

Fridman,R., Bird,R.E., Hoyhtya,M., Oelkuct,M., Komarek,D., Liang,C.M., Berman,M.L., Liotta,L.A., Stetler-Stevenson,W.G. and Fuerst,T.R. Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme Biochem J (1993) 289, 411-416. PubMed Europe PubMed PMC EPMC E
Hill,P.A., Reynolds,J.J. and Meikle,M.C. Inhibition of stimulated bone resorption in vitro by TIMP- 1 and TIMP-2 Biochim Biophys Acta (1993) 1177, 71-74. PubMed Europe PubMed DOI
[YEAR:27-4-1993]Willenbrock,F., Crabbe,T., Slocombe,P.M., Sutton,C.W., Docherty,A.J., Cockett,M.I., O'Shea,M., Brocklehurst,K., Phillips,I.R. and Murphy,G. The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A Biochemistry (27-4-1993) 32, 4330-4337. PubMed Europe PubMed

1992

Kleiner,D.E., Jr., Unsworth,E.J., Krutzsch,H.C. and Stetler-Stevenson,W.G. Higher-order complex formation between the 72-kilodalton type IV collagenase and tissue inhibitor of metalloproteinases- 2 Biochemistry (1992) 31, 1665-1672. PubMed Europe PubMed
Roswit,W.T., McCourt,D.W., Partridge,N.C. and Jeffrey,J.J. Purification and sequence analysis of two rat tissue inhibitors of metalloproteinases Arch Biochem Biophys (1992) 292, 402-410. PubMed Europe PubMed DOI

1991

Howard,E.W. and Banda,M.J. Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site J Biol Chem (1991) 266, 17972-17977. PubMed Europe PubMed
Kolkenbrock,H., Orgel,D., Hecker-Kia,A., Noack,W. and Ulbrich,N. The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor Eur J Biochem (1991) 198, 775-781. PubMed Europe PubMed
Ward,R.V., Hembry,R.M., Reynolds,J.J. and Murphy,G. The purification of tissue inhibitor of metalloproteinases- 2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases- 2 and tissue inhibitor of metalloproteinases-1 Biochem J (1991) 278, 179-187. PubMed Europe PubMed PMC EPMC

1989

[YEAR:15-10-1989]Stetler-Stevenson,W.G., Krutzsch,H.C. and Liotta,L.A. Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family J Biol Chem (15-10-1989) 264, 17374-17378. PubMed Europe PubMed