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Literature for inhibitor I35.001: timp-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: A Assay, S Structure, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Li,C., Lu,G., Chen,H., Wang,C., Wang,Z., Ming,R., Liu,S. and Huang,L.
    A nanosystem targeting tissue inhibitor of metalloproteinase-1 for continuous spatiotemporal idiopathic pulmonary fibrosis therapy
    Nat Commun (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Bhattacharjee,S. and Rasool,M.
    Harnessing the therapeutic potential of TIMP-1 in autoimmune inflammation: A prospective insight
    Pathol Res Pract (2025) 278, 156334-156334. PubMed  Europe PubMed DOI
  3. Haussler,D., Manevski,D., Fradrich,J., Brunner,V., Prokopchuk,O., Sommer,A., Toledo,B., Knolle,P., Martignoni,M.E., Friess,H., Waterhouse,P. and Kruger,A.
    Extent of N-glycosylation of the metalloproteinase inhibitor and cytokine TIMP-1 determines pancreatic cancer cell proliferation and survival via CD63
    J Biol Chem (2025) , 110211-110211. PubMed  Europe PubMed DOI
  4. Lin,X., Chen,Y., Zhong,B. and Yu,H.
    Cathepsin K and glycosaminoglycans differentially regulate matrix metalloproteinase activity in dentin under various pH conditions
    Int J Biol Macromol (2025) 327, 147486-147486. PubMed  Europe PubMed DOI  L
  5. Rao,Y., Pan,Q., Liu,S., Yao,S., Li,L., Yan,J., Chen,L., Xu,L., Yan,H., Ma,A., Wang,F., Mao,X., Wang,Z., Zhang,J., Guo,J. and Sun,Z.
    Tissue Inhibitor of Metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis
    J Biol Chem (2025) , 108473-108473. PubMed  Europe PubMed DOI  K
    6. 2024
  6. Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E.
    Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target
    Basic Clin Pharmacol Toxicol (2024) 134, 727-736. PubMed  Europe PubMed DOI  L
  7. Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J.
    Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Golombek,S., Doll,I., Kaufmann,L., Lescan,M., Schlensak,C. and Avci-Adali,M.
    A Novel Strategy for the Treatment of Aneurysms: Inhibition of MMP-9 Activity through the Delivery of TIMP-1 Encoding Synthetic mRNA into Arteries
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  L
  9. Nakamura,K., Tsukasaki,M., Tsunematsu,T., Yan,M., Ando,Y., Huynh,N.C., Hashimoto,K., Gou,Q., Muro,R., Itabashi,A., Iguchi,T., Okamoto,K., Nakamura,T., Nakano,K., Okamura,T., Ueno,T., Ito,K., Ishimaru,N., Hoshi,K. and Takayanagi,H.
    The periosteum provides a stromal defence against cancer invasion into the bone
    Nature (2024) 634, 474-481. PubMed  Europe PubMed DOI
  10. Ranta,J., Havulinna,A.S., Tervahartiala,T., Niemi,K., Aarabi,G., Vihervaara,T., Salomaa,V., Sorsa,T., Pussinen,P.J. and Salminen,A.
    Serum MMP-8 and TIMP-1 concentrations in a population-based cohort: effects of age, gender, and health status
    Front Dent Med (2024) 5, 1315596-1315596. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Sutter,P.A., Willis,C.M., Menoret,A., Nicaise,A.M., Sacino,A., Sikkema,A.H., Jellison,E.R., Win,K.K., Han,D.K., Church,W., Baron,W., Vella,A.T. and Crocker,S.J.
    Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses
    Proc Natl Acad Sci U S A (2024) 121, e2306816121-e2306816121. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2023
  12. Almuntashiri,S., Alhumaid,A., Zhu,Y., Han,Y., Dutta,S., Khilji,O., Zhang,D. and Wang,X.
    TIMP-1 and its potential diagnostic and prognostic value in pulmonary diseases
    Chin Med J Pulm Crit Care Med (2023) 1, 67-76. PubMed  Europe PubMed DOI  PMC  EPMC  V
  13. Cao,T.B.T., Quoc,Q.L., Yang,E.M., Moon,J.Y., Shin,Y.S., Ryu,M.S., Choi,Y. and Park,H.S.
    Tissue Inhibitor of Metalloproteinase-1 Enhances Eosinophilic Airway Inflammation in Severe Asthma
    Allergy Asthma Immunol Res (2023) 15, 451-472. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Dimic-Janjic,S., Hoda,M.A., Milenkovic,B., Kotur-Stevuljevic,J., Stjepanovic,M., Gompelmann,D., Jankovic,J., Miljkovic,M., Milin-Lazovic,J., Djurdjevic,N., Maric,D., Milivojevic,I. and Popevic,S.
    The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
    Eur J Med Res (2023) 28, 127-127. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Kim,S.H.
    Roles of Tissue Inhibitor of Metalloproteinase-1 in Severe Asthma
    Allergy Asthma Immunol Res (2023) 15, 416-418. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Sharifi,M.A., Wierer,M., Dang,T.A., Milic,J., Moggio,A., Sachs,N., von Scheidt,M., Hinterdobler,J., Muller,P., Werner,J., Stiller,B., Aherrahrou,Z., Erdmann,J., Zaliani,A., Graettinger,M., Reinshagen,J., Gul,S., Gribbon,P., Maegdefessel,L., Bernhagen,J., Sager,H.B., Mann,M., Schunkert,H. and Kessler,T.
    ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1
    Circ Res (2023) 133, 674-686. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2022
  17. Raeeszadeh-Sarmazdeh,M., Coban,M., Mahajan,S., Hockla,A., Sankaran,B., Downey,G.P., Radisky,D.C. and Radisky,E.S.
    Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10
    J Biol Chem (2022) 298, 101654-101654. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2021
  18. Huang,S., Chen,M., Yu,H., Lin,K., Guo,Y. and Zhu,P.
    Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemiareperfusion injury by promoting angiogenesis and inhibiting oxidative stress
    Mol Med Rep (2021) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Nissi,R., Santala,M. and Talvensaari-Mattila,A.
    The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study
    BMC Res Notes (2021) 14, 31-31. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Schoeps,B., Eckfeld,C., Fluter,L., Keppler,S., Mishra,R., Knolle,P., Bayerl,F., Bottcher,J., Hermann,C.D., Haussler,D. and Kruger,A.
    Identification of invariant chain CD74 as a functional receptor of tissue inhibitor of metalloproteinases-1 (TIMP-1)
    J Biol Chem (2021) , 101072-101072. PubMed  Europe PubMed DOI
  21. Vashum,Y., Premsingh,R., Kottaiswamy,A., Soma,M., Padmanaban,A., Kalaiselvan,P. and Samuel,S.
    Inhibitory effect of cathepsin K inhibitor (ODN-MK-0822) on invasion, migration and adhesion of human breast cancer cells in vitro
    Mol Biol Rep (2021) 48, 105-116. PubMed  Europe PubMed DOI  I
  22. Wang,X., Zhang,D., Fucci,Q.A., Dollery,C.M. and Owen,C.A.
    Surface-bound matrix metalloproteinase-8 on macrophages: Contributions to macrophage pericellular proteolysis and migration through tissue barriers
    Physiol Rep (2021) 9, e14778-e14778. PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2020
  23. Abd-Elhakim,Y.M., Mohamed,W.A.M., El Bohi,K.M., Ali,H.A., Mahmoud,F.A. and Saber,T.M.
    Prevention of melamine-induced hepatorenal impairment by an ethanolic extract of Moringa oleifera: Changes in KIM-1, TIMP-1, oxidative stress, apoptosis, and inflammation-related genes
    Gene (2020) 764, 145083-145083. PubMed  Europe PubMed DOI
  24. Abety,A.N., Pach,E., Giebeler,N., Fromme,J.E., Aramadhaka,L.R., Mauch,C., Fox,J.W. and Zigrino,P.
    Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth
    Biomolecules (2020) 10 PubMed  Europe PubMed DOI
  25. Aoki,M., Matsumoto,N.M., Dohi,T., Kuwahawa,H., Akaishi,S., Okubo,Y., Ogawa,R., Yamamoto,H. and Takabe,K.
    Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars
    Mol Ther Nucleic Acids (2020) 22, 50-61. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Arai,A.L., Migliorini,M., Au,D.T., Hahn-Dantona,E., Peeney,D., Stetler-Stevenson,W.G., Muratoglu,S.C. and Strickland,D.K.
    High-Affinity Binding of LDL Receptor-Related Protein 1 to Matrix Metalloprotease 1 Requires Protease:Inhibitor Complex Formation
    Biochemistry (2020) 59, 2922-2933. PubMed  Europe PubMed DOI
  27. Azevedo Martins,J.M., Rabelo-Santos,S.H., do Amaral Westin,M.C. and Zeferino,L.C.
    Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis
    BMC Cancer (2020) 20, 660-660. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Carreca,A.P., Pravata,V.M., Markham,M., Bonelli,S., Murphy,G., Nagase,H., Troeberg,L. and Scilabra,S.D.
    TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1
    Sci Rep (2020) 10, 12067-12067. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Dias,F., Teixeira,A.L., Nogueira,I., Morais,M., Maia,J., Bodo,C., Ferreira,M., Vieira,I., Silva,J., Lobo,J., Sequeira,J.P., Mauricio,J., Oliveira,J., Palmeira,C., Martins,G., Kok,K., Costa-Silva,B. and Medeiros,R.
    Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  30. Glogowska-Ligus,J., Dabek,J., Piechota,M., Gallert-Kopyto,W., Lepich,T., Korzen,D. and Gasior,Z.
    Can the expression of the metalloproteinase 9 gene and its inhibitor be considered as markers of heart failure?
    Minerva Cardioangiol (2020) PubMed  Europe PubMed DOI
  31. Kim,J. and Kim,M.M.
    Effect of Lapachol on the Inhibition of Matrix Metalloproteinase Related to the Invasion of Human Fibrosarcoma Cells
    Curr Mol Pharmacol (2020) PubMed  Europe PubMed DOI
  32. Malik,A., Pal,R. and Gupta,S.K.
    EGF-mediated reduced miR-92a-1-5p controls HTR-8/SVneo cell invasion through activation of MAPK8 and FAS which in turn increase MMP-2/-9 expression
    Sci Rep (2020) 10, 12274-12274. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Rethnam,M., Tan,D.Q. and Suda,T.
    Myeloma cells self-promote migration by regulating TAB1-driven TIMP-1 expression in mesenchymal stem cells
    Biochem Biophys Res Commun (2020) PubMed  Europe PubMed DOI
  34. Salah,N.Y.
    Vascular endothelial growth factor (VEGF), tissue inhibitors of metalloproteinase-1 (TIMP-1) and nail fold capillaroscopy changes in children and adolescents with Gaucher disease; relation to residual disease severity
    Cytokine (2020) 133, 155120-155120. PubMed  Europe PubMed DOI
  35. Shabani Sadr,N.K., Shafiei,M., Galehdari,H. and Khirolah,A.
    The Effect of Sialic Acid on the Expression of miR-218, NF-kB, MMP-9, and TIMP-1
    Biochem Genet (2020) 58, 883-900. PubMed  Europe PubMed DOI
  36. Vira,H.J., Pradhan,V.D., Umare,V.D., Chaudhary,A.K., Rajadhyksha,A.G., Nadkar,M.Y., Ghosh,K. and Nadkarni,A.H.
    Expression of the matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in systemic lupus erythematosus patients
    Neth J Med (2020) 78, 261-268. PubMed  Europe PubMed
  37. Wang,L., Zhang,C.G., Jia,Y.L. and Hu,L.
    Tissue Inhibitor of Metalloprotease-1 (TIMP-1) Regulates Adipogenesis of Adipose-derived Stem Cells (ASCs) via the Wnt Signaling Pathway in an MMP-independent Manner
    Curr Med Sci (2020) 40, 989-996. PubMed  Europe PubMed DOI  K
  38. Yang,B., Zhang,D., Qian,J. and Cheng,Y.
    Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system
    Mol Cell Biochem (2020) 474, 199-208. PubMed  Europe PubMed DOI
  39. Yari,D., Ehsanbakhsh,Z., Validad,M.H. and Langroudi,F.H.
    Association of TIMP-1 and COL4A4 Gene Polymorphisms with Keratoconus in an Iranian Population
    J Ophthalmic Vis Res (2020) 15, 299-307. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Yue,Y., Hsiao,Y.W. and Zhou,J.B.
    Association between MMP/TIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients
    Biomed Res Int (2020) 2020, 2961742-2961742. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Zhang,Y., Liu,H., Chen,Z., Yu,M., Li,J., Dong,H., Li,N., Ding,X., Ge,Y., Liu,C., Ma,T. and Gui,B.
    TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice
    Neurochem Int (2020) 140, 104818-104818. PubMed  Europe PubMed DOI
  42. Zhao,L., Song,C., Huang,Y., Lei,W. and Sun,J.
    MMP-9 regulates CX3CL1/CX3CR1 in the early phase of neuropathic pain in chronic sciatic nerve constriction injury (CCI) rats
    Ann Palliat Med (2020) 9, 2020-2027. PubMed  Europe PubMed DOI  K
    43. 2019
  43. Grunwald,B., Schoeps,B. and Kruger,A.
    Recognizing the molecular multifunctionality and interactome of TIMP-1
    Trends Cell Biol (2019) 29, 6-19. PubMed  Europe PubMed DOI
  44. Jiang,B., Liu,J. and Lee,M.H.
    Targeting a designer TIMP-1 to the cell surface for effective MT1-MMP inhibition: a potential role for the prion protein in renal carcinoma therapy
    Molecules (2019) 24 PubMed  Europe PubMed DOI
  45. Raeeszadeh-Sarmazdeh,M., Greene,K.A., Sankaran,B., Downey,G.P., Radisky,D.C. and Radisky,E.S.
    Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition
    J Biol Chem (2019) 294, 9476-9488. PubMed  Europe PubMed DOI
    46. 2016
  46. Breynaert,C., de Bruyn,M., Arijs,I., Cremer,J., Martens,E., Van Lommel,L., Geboes,K., De Hertogh,G., Schuit,F., Ferrante,M., Vermeire,S., Ceuppens,J., Opdenakker,G. and Van Assche,G.
    Genetic deletion of tissue inhibitor of metalloproteinase-1/TIMP-1 alters inflammation and attenuates fibrosis in dextran sodium sulphate-induced murine models of colitis
    J Crohns Colitis (2016) 10, 1336-1350. PubMed  Europe PubMed DOI  K
  47. Guo,C., Tsigkou,A. and Lee,M.H.
    ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4
    Biomed Rep (2016) 4, 73-78. PubMed  Europe PubMed DOI  PMC  EPMC  I
    48. 2015
  48. Bein,A., Lubetzky,R., Mandel,D. and Schwartz,B.
    TIMP-1 inhibition of occludin degradation in Caco-2 intestinal cells: a potential protective role in necrotizing enterocolitis
    Pediatr Res (2015) 77, 649-655. PubMed  Europe PubMed DOI
  49. Chang,Y.H., Chiu,Y.J., Cheng,H.C., Liu,F.J., Lai,W.W., Chang,H.J. and Liao,P.C.
    Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma
    Tumour Biol (2015) 36, 3957-3967. PubMed  Europe PubMed DOI  K
  50. Sun,Y.L., Xie,H., Lin,H.L., Feng,Q. and Liu,Y.
    Construction and identification of recombinant adenovirus carrying human TIMP-1shRNA gene
    Genet Mol Res (2015) 14, 199-208. PubMed  Europe PubMed DOI
  51. Trentini,A., Manfrinato,M.C., Castellazzi,M., Tamborino,C., Roversi,G., Volta,C.A., Baldi,E., Tola,M.R., Granieri,E., Dallocchio,F., Bellini,T. and Fainardi,E.
    TIMP-1 resistant matrix metalloproteinase-9 is the predominant serum active isoform associated with MRI activity in patients with multiple sclerosis
    Mult Scler (2015) 21, 1121-1130. PubMed  Europe PubMed DOI
  52. Vandooren,J., Born,B., Solomonov,I., Zajac,E., Saldova,R., Senske,M., Ugarte-Berzal,E., Martens,E., Van Den Steen,P.E., Van Damme,J., Garcia-Pardo,A., Froeyen,M., Deryugina,E.I., Quigley,J.P., Moestrup,S.K., Rudd,P.M., Sagi,I. and Opdenakker,G.
    Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1
    Biochem J (2015) 465, 259-270. PubMed  Europe PubMed DOI
    53. 2014
  53. Aoki,M., Miyake,K., Ogawa,R., Dohi,T., Akaishi,S., Hyakusoku,H. and Shimada,T.
    siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type I
    J Invest Dermatol (2014) 134, 818-826. PubMed  Europe PubMed DOI  K
  54. Herszenyi,L.
    TIMP-1: a strong player in colorectal cancer
    J Gastrointestin Liver Dis (2014) 23, 365-366. PubMed  Europe PubMed DOI
  55. Nieuwesteeg,M.A., Willson,J.A., Cepeda,M., Fox,M.A. and Damjanovski,S.
    Functional characterization of tissue inhibitor of metalloproteinase-1 (TIMP-1) N- and C-terminal domains during Xenopus laevis development
    ScientificWorldJournal (2014) 2014, 467907-467907. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Wang,H.-X., Yang,Q.-D., Liu,B.-Q., Zhang,L., Ma,M.-M., Hu,Z.-Y., Xia,J., Xu,H.-W. and Du,X.-P.
    TIMP-1 polymorphisms in a Chinese Han population with intracerebral hemorrhage
    Int J Neurosci (2014) 124, 61-67. PubMed  Europe PubMed DOI  M
    57. 2013
  57. Behnes,M., Bertsch,T. and Hoffmann,U.
    TIMP-1 gene polymorphism: are genetics able to predict outcome of septic patients?
    Crit Care (2013) 17, 170-170. PubMed  Europe PubMed DOI  M
  58. Djafarzadeh,R., Notohamiprodjo,S., Rieth,N., Hofstetter,M., Noessner,E. and Nelson,P.J.
    Treatment of dermal fibroblasts with GPI-anchored human TIMP-1 protein moderates processes linked to scar formation
    J Invest Dermatol (2013) 133, 803-811. PubMed  Europe PubMed DOI  U
  59. Lorente,L. and Mart,N.
    The 372 T/C genetic polymorphism of TIMP-1 as a biomarker of mortality in patients with sepsis
    Crit Care (2013) 17, 456-456. PubMed  Europe PubMed DOI  M
  60. Tang,H., Mao,J., Gao,L., Liu,J. and Wu,T.
    Effect of antisense TIMP-1 cDNA on the expression of TIMP-1 and MMP-2 in lung tissue with pulmonary fibrosis induced by bleomycin
    Mol Med Rep (2013) 7, 149-153. PubMed  Europe PubMed DOI
    61. 2012
  61. Batra,J., Robinson,J., Soares,A.S., Fields,A.P., Radisky,D.C. and Radisky,E.S.
    Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure
    J Biol Chem (2012) 287, 15935-15946. PubMed  Europe PubMed DOI  S
  62. Duarte,S., Hamada,T., Kuriyama,N., Busuttil,R.W. and Coito,A.J.
    TIMP-1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury
    Hepatology (2012) 56, 1074-1085. PubMed  Europe PubMed DOI  K
  63. Wang,N., Zhu,M., Tsao,S.W., Man,K., Zhang,Z. and Feng,Y.
    Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma
    PLoS ONE (2012) 7, e46318-e46318. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Yokose,U., Hachiya,A., Sriwiriyanont,P., Fujimura,T., Visscher,M.O., Kitzmiller,W.J., Bello,A., Tsuboi,R., Kitahara,T., Kobinger,G.P. and Takema,Y.
    The endogenous protease inhibitor TIMP-1 mediates protection and recovery from cutaneous photodamage
    J Invest Dermatol (2012) 132, 2800-2809. PubMed  Europe PubMed DOI
    65. 2011
  65. Fowell,A.J., Collins,J.E., Duncombe,D.R., Pickering,J.A., Rosenberg,W.M. and Benyon,R.C.
    Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation
    Biochem Biophys Res Commun (2011) 407, 277-282. PubMed  Europe PubMed DOI  K
  66. Schelter,F., Grandl,M., Seubert,B., Schaten,S., Hauser,S., Gerg,M., Boccaccio,C., Comoglio,P. and Kruger,A.
    Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10
    Clin Exp Metastasis (2011) 28, 793-802. PubMed  Europe PubMed DOI
    67. 2010
  67. Grossman,M., Tworowski,D., Dym,O., Lee,M.H., Levy,Y., Murphy,G. and Sagi,I.
    The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function
    Biochemistry (2010) 49, 6184-6192. PubMed  Europe PubMed DOI
  68. Lee,M.H., Atkinson,S., Rapti,M., Handsley,M., Curry,V., Edwards,D. and Murphy,G.
    The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment
    Cancer Lett (2010) 290, 114-122. PubMed  Europe PubMed DOI
    69. 2009
  69. Sands,M.F., Ohtake,P.J., Mahajan,S.D., Takyar,S.S., Aalinkeel,R., Fang,Y.V., Blume,J.W., Mullan,B.A., Sykes,D.E., Lachina,S., Knight,P.R. and Schwartz,S.A.
    Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthma
    Clin Immunol (2009) 130, 186-198. PubMed  Europe PubMed DOI  PMC  EPMC  K
  70. Tejima,E., Guo,S., Murata,Y., Arai,K., Lok,J., van Leyen,K., Rosell,A., Wang,X. and Lo,E.H.
    Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1
    J Neurotrauma (2009) 26, 1935-1941. PubMed  Europe PubMed DOI  U
  71. Thorne,M., Moore,C.S. and Robertson,G.S.
    Lack of TIMP-1 increases severity of experimental autoimmune encephalomyelitis: effects of darbepoetin alfa on TIMP-1 null and wild-type mice
    J Neuroimmunol (2009) 211, 92-100. PubMed  Europe PubMed DOI  K
    72. 2008
  72. Deng,X., He,G., Levine,A., Cao,Y. and Mullins,C.
    Adenovirus-mediated expression of TIMP-1 and TIMP-2 in bone inhibits osteolytic degradation by human prostate cancer
    Int J Cancer (2008) 122, 209-218. PubMed  Europe PubMed DOI  U
  73. Liu,H., Chen,B. and Lilly,B.
    Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1
    Angiogenesis (2008) 11, 223-234. PubMed  Europe PubMed DOI
  74. Obro,N.F., Lademann,U., Birkenkamp-Demtroder,K., Holten-Andersen,L., Brunner,N. and Offenberg,H.
    A TIMP-1 splice variant transcript: Possible role in regulation of TIMP-1 expression
    Cancer Lett (2008) 262, 64-70. PubMed  Europe PubMed DOI  M
  75. Rapti,M., Atkinson,S.J., Lee,M.H., Trim,A., Moss,M. and Murphy,G.
    The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition
    Biochem J (2008) 411, 433-439. PubMed  Europe PubMed DOI
  76. Van Doren,S.R., Wei,S., Gao,G., DaGue,B.B., Palmier,M.O., Bahudhanapati,H. and Brew,K.
    Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in Bacteria
    Biopolymers (2008) 89, 960-968. PubMed  Europe PubMed DOI
    77. 2007
  77. Hamze,A.B., Wei,S., Bahudhanapati,H., Kota,S., Acharya,K.R. and Brew,K.
    Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors
    Protein Sci (2007) 16, 1905-1913. PubMed  Europe PubMed DOI  PMC  EPMC
  78. Iyer,S., Wei,S., Brew,K. and Acharya,K.R.
    Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1
    J Biol Chem (2007) 282, 364-371. PubMed  Europe PubMed DOI  S
  79. Roderfeld,M., Graf,J., Giese,B., Salguero-Palacios,R., Tschuschner,A., Muller-Newen,G. and Roeb,E.
    Latent MMP-9 is bound to TIMP-1 before secretion
    Biol Chem (2007) 388, 1227-1234. PubMed  Europe PubMed DOI
  80. Wang,Y., Rosen,H., Madtes,D.K., Shao,B., Martin,T.R., Heinecke,J.W. and Fu,X.
    Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: An oxidative mechanism for regulating proteolysis during inflammation
    J Biol Chem (2007) 282, 31826-31834. PubMed  Europe PubMed DOI
  81. Xia,D., Yan,L., Xu,L., Tong,Y., Zuo,H. and Zhao,L.
    [Construction of recombinant adenovirus vector carrying human TIMP-1 cDNA and its expression in vitro]
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi (2007) 24, 420-424. PubMed  Europe PubMed
    82. 2006
  82. [YEAR:31-10-2006]Djafarzadeh,R., Noessner,E., Engelmann,H., Schendel,D.J., Notohamiprodjo,M., von Luettichau,I. and Nelson,P.J.
    GPI-anchored TIMP-1 treatment renders renal cell carcinoma sensitive to FAS-meditated killing
    Oncogene (31-10-2006) 25, 1496-1508. PubMed  Europe PubMed DOI
  83. [YEAR:1-9-2006]Pinto,A.F., Terra,R.M., Guimaraes,J.A., Kashiwagi,M., Nagase,H., Serrano,S.M. and Fox,J.W.
    Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction
    Biochem Biophys Res Commun (1-9-2006) 347, 641-648. PubMed  Europe PubMed DOI
  84. [YEAR:15-12-2006]Tang,Z.Y., Loss,G., Carmody,I. and Cohen,A.J.
    TIMP-3 ameliorates hepatic ischemia/reperfusion injury through inhibition of tumor necrosis factor-alpha-converting enzyme activity in rats
    Transplantation (15-12-2006) 82, 1518-1523. PubMed  Europe PubMed DOI
  85. [YEAR:9-1-2006]Taube,M.E., Liu,X.W., Fridman,R. and Kim,H.R.
    TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein
    Oncogene (9-1-2006) 25, 3041-3048. PubMed  Europe PubMed DOI
    86. 2005
  86. Eskandari,M.K., Vijungco,J.D., Flores,A., Borensztajn,J., Shively,V. and Pearce,W.H.
    Enhanced abdominal aortic aneurysm in TIMP-1-deficient mice
    J Surg Res (2005) 123, 289-293. PubMed  Europe PubMed DOI  K
  87. [YEAR:12-10-2005]Guedez,L., Martinez,A., Zhao,S., Vivero,A., Pittaluga,S., Stetler-Stevenson,M., Raffeld,M. and Stetler-Stevenson,W.G.
    Tissue inhibitor of metalloproteinase 1 (TIMP-1) promotes plasmablastic differentiation of a Burkitt lymphoma cell line: implications in the pathogenesis of plasmacytic/plasmablastic tumors
    Blood (12-10-2005) 105, 1660-1668. PubMed  Europe PubMed DOI
  88. Ikonomidis,J.S., Hendrick,J.W., Parkhurst,A.M., Herron,A.R., Escobar,P.G., Dowdy,K.B., Stroud,R.E., Hapke,E., Zile,M.R. and Spinale,F.G.
    Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition
    Am J Physiol Heart Circ Physiol (2005) 288, H149-H158. PubMed  Europe PubMed DOI
  89. Jourquin,J., Tremblay,E., Bernard,A., Charton,G., Chaillan,F.A., Marchetti,E., Roman,F.S., Soloway,P.D., Dive,V., Yiotakis,A., Khrestchatisky,M. and Rivera,S.
    Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory
    Eur J Neurosci (2005) 22, 2569-2578. PubMed  Europe PubMed DOI
  90. Kenney,M.C., Chwa,M., Atilano,S.R., Tran,A., Carballo,M., Saghizadeh,M., Vasiliou,V., Adachi,W. and Brown,D.J.
    Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder
    Invest Ophthalmol Vis Sci (2005) 46, 823-832. PubMed  Europe PubMed DOI
  91. [YEAR:1-2-2005]Liu,X.W., Taube,M.E., Jung,K.K., Dong,Z., Lee,Y.J., Roshy,S., Sloane,B.F., Fridman,R. and Kim,H.R.
    Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1
    Cancer Res (1-2-2005) 65, 898-906. PubMed  Europe PubMed
  92. Lose,F., Thompson,P.J., Duffy,D., Stewart,G.A. and Kedda,M.A.
    A novel tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphism associated with asthma in Australian women
    Thorax (2005) 60, 623-628. PubMed  Europe PubMed DOI  PMC  EPMC  M
  93. [YEAR:22-2-2005]Mohammed,F.F., Pennington,C.J., Kassiri,Z., Rubin,J.S., Soloway,P.D., Ruther,U., Edwards,D.R. and Khokha,R.
    Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration
    Hepatology (22-2-2005) 41, 857-867. PubMed  Europe PubMed DOI
  94. [YEAR:3-5-2005]Moller Sorensen,N., Dowell,B.L., Stewart,K.D., Jensen,V., Larsen,L., Lademann,U., Murphy,G., Nielsen,H.J., Brunner,N. and Davis,G.J.
    Establishment and characterization of 7 new monoclonal antibodies to tissue inhibitor of metalloproteinases-1
    Tumour Biol (3-5-2005) 26, 71-80. PubMed  Europe PubMed DOI
    95. 2004
  95. [YEAR:5-11-2004]Akahane,T., Akahane,M., Shah,A. and Thorgeirsson,U.P.
    TIMP-1 stimulates proliferation of human aortic smooth muscle cells and Ras effector pathways
    Biochem Biophys Res Commun (5-11-2004) 324, 440-445. PubMed  Europe PubMed DOI
  96. [YEAR:10-12-2004]Akahane,T., Akahane,M., Shah,A., Connor,C.M. and Thorgeirsson,U.P.
    TIMP-1 inhibits microvascular endothelial cell migration by MMP-dependent and MMP-independent mechanisms
    Exp Cell Res (10-12-2004) 301, 158-167. PubMed  Europe PubMed DOI
  97. [YEAR:4-6-2004]Bertrand-Philippe,M., Ruddell,R.G., Arthur,M.J., Thomas,J., Mungalsingh,N. and Mann,D.A.
    Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2
    J Biol Chem (4-6-2004) 279, 24530-24539. PubMed  Europe PubMed DOI
  98. Duplantier,J.G., Dubuisson,L., Senant,N., Freyburger,G., Laurendeau,I., Herbert,J.M., Desmouliere,A. and Rosenbaum,J.
    A role for thrombin in liver fibrosis
    Gut (2004) 53, 1682-1687. PubMed  Europe PubMed DOI  PMC  EPMC  I
  99. [YEAR:14-9-2004]Ikonomidis,J.S., Gibson,W.C., Butler,J.E., McClister,D.M., Sweterlitsch,S.E., Thompson,R.P., Mukherjee,R. and Spinale,F.G.
    Effects of deletion of the tissue inhibitor of matrix metalloproteinases-1 gene on the progression of murine thoracic aortic aneurysms
    Circulation (14-9-2004) 110, II268-II273. PubMed  Europe PubMed DOI
  100. [YEAR:20-1-2004]Lee,M.H., Rapti,M., Knauper,V. and Murphy,G.
    Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition
    J Biol Chem (20-1-2004) 279, 17562-17569. PubMed  Europe PubMed DOI
    101. 2003
  101. [YEAR:28-3-2003]Arumugam,S., Gao,G., Patton,B.L., Semenchenko,V., Brew,K. and Van Doren,S.R.
    Increased backbone mobility in beta-barrel enhances entropy gain driving binding of N-TIMP-1 to MMP-3
    J Mol Biol (28-3-2003) 327, 719-734. PubMed  Europe PubMed DOI
  102. Arumugam,S. and Van Doren,S.R.
    Global orientation of bound MMP-3 and N-TIMP-1 in solution via residual dipolar couplings
    Biochemistry (2003) 42, 7950-7958. PubMed  Europe PubMed DOI  S
  103. [YEAR:20-6-2003]Ikenaka,Y., Yoshiji,H., Kuriyama,S., Yoshii,J., Noguchi,R., Tsujinoue,H., Yanase,K., Namisaki,T., Imazu,H., Masaki,T. and Fukui,H.
    Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1 transgenic mouse model
    Int J Cancer (20-6-2003) 105, 340-346. PubMed  Europe PubMed DOI
  104. [YEAR:15-6-2003]Lambert,E., Boudot,C., Kadri,Z., Soula-Rothhut,M., Sowa,M.L., Mayeux,P., Hornebeck,W., Haye,B. and Petitfrere,E.
    Tissue inhibitor of metalloproteinases-1 signalling pathway leading to erythroid cell survival
    Biochem J (15-6-2003) 372, 767-774. PubMed  Europe PubMed DOI  PMC  EPMC
  105. [YEAR:10-10-2003]Lee,M.H., Rapti,M. and Murphy,G.
    Unveiling the surface epitopes that render tissue inhibitor of metalloproteinase-1 inactive against membrane type 1-matrix metalloproteinase
    J Biol Chem (10-10-2003) 278, 40224-40230. PubMed  Europe PubMed DOI
  106. [YEAR:21-1-2003]Lemaitre,V., Soloway,P.D. and D'Armiento,J.
    Increased medial degradation with pseudo-aneurysm formation in apolipoprotein E-knockout mice deficient in tissue inhibitor of metalloproteinases-1
    Circulation (21-1-2003) 107, 333-338. PubMed  Europe PubMed DOI
  107. Nothnick,W.B.
    Tissue inhibitor of metalloproteinase-1 (TIMP-1) deficient mice display reduced serum progesterone levels during corpus luteum development
    Endocrinology (2003) 144, 5-8. PubMed  Europe PubMed DOI  K
    108. 2002
  108. [YEAR:6-11-2002]Furman,C., Luo,Z., Walsh,K., Duverger,N., Copin,C., Fruchart,J.C. and Rouis,M.
    Systemic tissue inhibitor of metalloproteinase-1 gene delivery reduces neointimal hyperplasia in balloon-injured rat carotid artery
    FEBS Lett (6-11-2002) 531, 122-126. PubMed  Europe PubMed DOI
    109. 2001
  109. [YEAR:13-4-2001]Hashimoto,G., Aoki,T., Nakamura,H., Tanzawa,K. and Okada,Y.
    Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)
    FEBS Lett (13-4-2001) 494, 192-195. PubMed  Europe PubMed DOI
    110. 2000
  110. Wu,B., Arumugam,S., Gao,G., Lee,G.I., Semenchenko,V., Huang,W., Brew,K. and Van Doren,S.R.
    NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases
    J Mol Biol (2000) 295, 257-268. PubMed  Europe PubMed DOI  S
    111. 1999
  111. [YEAR:9-4-1999]Meng,Q., Malinovskii,V., Huang,W., Hu,Y., Chung,L., Nagase,H., Bode,W., Maskos,K. and Brew,K.
    Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate
    J Biol Chem (9-4-1999) 274, 10184-10189. PubMed  Europe PubMed DOI
    112. 1998
  112. Suzuki,K., Kan,C.C., Hung,W., Gehring,M.R., Brew,K. and Nagase,H.
    Expression of human pro-matrix metalloproteinase 3 that lacks the N-terminal 34 residues in Escherichia coli: autoactivation and interaction with tissue inhibitor of metalloproteinase 1 (TIMP-1)
    Biol Chem (1998) 379, 185-191. PubMed  Europe PubMed
    113. 1997
  113. Gomez,D.E., Alonso,D.F., Yoshiji,H. and Thorgeirsson,U.P.
    Tissue inhibitors of metalloproteinases: structure, regulation and biological functions
    Eur J Cell Biol (1997) 74, 111-122. PubMed  Europe PubMed
  114. [YEAR:4-9-1997]Gomis-Ruth,F.X., Maskos,K., Betz,M., Bergner,A., Huber,R., Suzuki,K., Yoshida,N., Nagase,H., Brew,K., Bourenkov,G.P., Bartunik,H. and Bode,W.
    Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1
    Nature (4-9-1997) 389, 77-81. PubMed  Europe PubMed DOI  S
  115. Nagase,H., Suzuki,K., Cawston,T.E. and Brew,K.
    Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1)
    Biochem J (1997) 325, 163-167. PubMed  Europe PubMed  PMC  EPMC
  116. [YEAR:1-1-1997]Oliver,G.W., Leferson,J.D., Stetler-Stevenson,W.G. and Kleiner,D.E.
    Quantitative reverse zymography: analysis of picogram amounts of metalloproteinase inhibitors using gelatinase A and B reverse zymograms
    Anal Biochem (1-1-1997) 244, 161-166. PubMed  Europe PubMed DOI  A
  117. Vallon,R., Muller,R., Moosmayer,D., Gerlach,E. and Angel,P.
    The catalytic domain of activated collagenase I (MMP-1) is absolutely required for interaction with its specific inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP- 1)
    Eur J Biochem (1997) 244, 81-88. PubMed  Europe PubMed
    118. 1996
  118. Taylor,K.B., Windsor,L.J., Caterina,N.C., Bodden,M.K. and Engler,J.A.
    The mechanism of inhibition of collagenase by TIMP-1
    J Biol Chem (1996) 271, 23938-23945. PubMed  Europe PubMed DOI
    119. 1995
  119. Itoh,Y. and Nagase,H.
    Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase
    J Biol Chem (1995) 270, 16518-16521. PubMed  Europe PubMed DOI
  120. Murphy,G. and Willenbrock,F.
    Tissue inhibitors of matrix metalloendopeptidases
    Methods Enzymol (1995) 248, 496-510. PubMed  Europe PubMed DOI  V
    121. 1994
  121. [YEAR:29-4-1994]Baragi,V.M., Fliszar,C.J., Conroy,M.C., Ye,Q.Z., Shipley,J.M. and Welgus,H.G.
    Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin
    J Biol Chem (29-4-1994) 269, 12692-12697. PubMed  Europe PubMed
  122. Cocuzzi,E.T., Walther,S.E. and Denhardt,D.T.
    Expression and secretion of active mouse TIMP-1 using a baculovirus expression vector
    Inflammation (1994) 18, 35-43. PubMed  Europe PubMed  E
  123. Nguyen,Q., Willenbrock,F., Cockett,M.I., O'Shea,M., Docherty,A.J. and Murphy,G.
    Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A
    Biochemistry (1994) 33, 2089-2095. PubMed  Europe PubMed
  124. Okada,A., Garnier,J.M., Vicaire,S. and Basset,P.
    Cloning of the cDNA encoding rat tissue inhibitor of metalloproteinase 1 (TIMP-1), amino acid comparison with other TIMPs, and gene expression in rat tissues
    Gene (1994) 147, 301-302. PubMed  Europe PubMed DOI
  125. Williamson,R.A., Bartels,H., Murphy,G. and Freedman,R.B.
    Folding and stability of the active N-terminal domain of tissue inhibitor of metalloproteinases-1 and -2
    Protein Eng (1994) 7, 1035-1040. PubMed  Europe PubMed
    126. 1993
  126. Hill,P.A., Reynolds,J.J. and Meikle,M.C.
    Inhibition of stimulated bone resorption in vitro by TIMP- 1 and TIMP-2
    Biochim Biophys Acta (1993) 1177, 71-74. PubMed  Europe PubMed DOI
  127. [YEAR:28-12-1993]Kleine,T., Bartsch,S., Blaser,J., Schnierer,S., Triebel,S., Valentin,M., Gote,T. and Tschesche,H.
    Preparation of active recombinant TIMP-1 from Escherichia coli inclusion bodies and complex formation with the recombinant catalytic domain of PMNL-collagenase
    Biochemistry (28-12-1993) 32, 14125-14131. PubMed  Europe PubMed DOI
    128. 1992
  128. Alexander,C.M. and Werb,Z.
    Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro
    J Cell Biol (1992) 118, 727-739. PubMed  Europe PubMed DOI  PMC  EPMC  K
  129. Clissold,P.M.
    A cDNA construct of tissue inhibitor of metalloproteinases (TIMP) linked to the last exon of Thy-1 confers glycophospholipid anchorage on this naturally secreted protein
    Biochem J (1992) 281, 129-136. PubMed  Europe PubMed  PMC  EPMC
  130. Roswit,W.T., McCourt,D.W., Partridge,N.C. and Jeffrey,J.J.
    Purification and sequence analysis of two rat tissue inhibitors of metalloproteinases
    Arch Biochem Biophys (1992) 292, 402-410. PubMed  Europe PubMed DOI
  131. Sudbeck,B.D., Jeffrey,J.J., Welgus,H.G., Mecham,R.P., McCourt,D. and Parks,W.C.
    Purification and characterization of bovine interstitial collagenase and tissue inhibitor of metalloproteinases
    Arch Biochem Biophys (1992) 293, 370-376. PubMed  Europe PubMed DOI
    132. 1991
  132. Clark,I.M., Powell,L.K., Wright,J.K. and Cawston,T.E.
    Polyclonal and monoclonal antibodies against human tissue inhibitor of metalloproteinases (TIMP) and the design of an enzyme-linked immunosorbent assay to measure TIMP
    Matrix (1991) 11, 76-85. PubMed  Europe PubMed
  133. [YEAR:20-8-1991]Murphy,G., Houbrechts,A., Cockett,M.I., Williamson,R.A., O'Shea,M. and Docherty,A.J.
    The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity
    Biochemistry (20-8-1991) 30, 8097-8102. PubMed  Europe PubMed
    134. 1990
  134. Freudenstein,J., Wagner,S., Luck,R.M., Einspanier,R. and Scheit,K.H.
    mRNA of bovine tissue inhibitor of metalloproteinase: sequence and expression in bovine ovarian tissue
    Biochem Biophys Res Commun (1990) 171, 250-256. PubMed  Europe PubMed DOI
  135. Lelievre,Y., Bouboutou,R., Boiziau,J., Faucher,D., Achard,D. and Cartwright,T.
    Low molecular weight, sequence based, collagenase inhibitors selectively block the interaction between collagenase and TIMP (tissue inhibitor of metalloproteinases)
    Matrix (1990) 10, 292-299. PubMed  Europe PubMed  I
  136. Williamson,R.A., Marston,F.A., Angal,S., Koklitis,P., Panico,M., Morris,H.R., Carne,A.F., Smith,B.J., Harris,T.J. and Freedman,R.B.
    Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP)
    Biochem J (1990) 268, 267-274. PubMed  Europe PubMed  PMC  EPMC
    137. 1986
  137. Cawston,T.E.
    Protein inhibitors of metallo-proteinases
    [ISSN:0-444-80763-2] (1986) , 589-612.
    138. 1985
  138. [YEAR:7-11-1985]Docherty,A.J., Lyons,A., Smith,B.J., Wright,E.M., Stephens,P.E., Harris,T.J., Murphy,G. and Reynolds,J.J.
    Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity
    Nature (7-11-1985) 318, 66-69. PubMed  Europe PubMed
  139. [YEAR:27-6-1985]Gasson,J.C., Golde,D.W., Kaufman,S.E., Westbrook,C.A., Hewick,R.M., Kaufman,R.J., Wong,G.G., Temple,P.A., Leary,A.C. and Brown,E.L.
    Molecular characterization and expression of the gene encoding human erythroid-potentiating activity
    Nature (27-6-1985) 315, 768-771. PubMed  Europe PubMed
  140. [YEAR:1-11-1985]Mercer,E., Cawston,T.E., de Silva,M. and Hazleman,B.L.
    Purification of a metalloproteinase inhibitor from human rheumatoid synovial fluid
    Biochem J (1-11-1985) 231, 505-510. PubMed  Europe PubMed  PMC  EPMC
  141. [YEAR:17-4-1985]Murphy,G. and Werb,Z.
    Tissue inhibitor of metalloproteinases. Identification of precursor forms synthesized by human fibroblasts in culture
    Biochim Biophys Acta (17-4-1985) 839, 214-218. PubMed  Europe PubMed DOI
    142. 1984
  142. [YEAR:15-2-1984]Dean,D.D. and Woessner,J.F., Jr.
    Extracts of human articular cartilage contain an inhibitor of tissue metalloproteinases
    Biochem J (15-2-1984) 218, 277-280. PubMed  Europe PubMed  PMC  EPMC
    143. 1983
  143. [YEAR:18-10-1983]Morales,T.I., Kuettner,K.E., Howell,D.S. and Woessner,J.F.
    Characterization of the metalloproteinase inhibitor produced by bovine articular chondrocyte cultures
    Biochim Biophys Acta (18-10-1983) 760, 221-229. PubMed  Europe PubMed DOI
  144. [YEAR:25-10-1983]Stricklin,G.P. and Welgus,H.G.
    Human skin fibroblast collagenase inhibitor. Purification and biochemical characterization
    J Biol Chem (25-10-1983) 258, 12252-12258. PubMed  Europe PubMed  I
    145. 1981
  145. [YEAR:16-6-1981]Aggeler,J., Engvall,E. and Werb,Z.
    An irreversible tissue inhibitor of collagenase in human amniotic fluid: characterization and separation from fibronectin
    Biochem Biophys Res Commun (16-6-1981) 100, 1195-1201. PubMed  Europe PubMed
  146. [YEAR:1-4-1981]Cawston,T.E., Galloway,W.A., Mercer,E., Murphy,G. and Reynolds,J.J.
    Purification of rabbit bone inhibitor of collagenase
    Biochem J (1-4-1981) 195, 159-165. PubMed  Europe PubMed  PMC  EPMC
  147. McGuire,M.B., Murphy,G., Reynolds,J.J. and Russell,R.G.
    Production of collagenase and inhibitor (TIMP) by normal, rheumatoid and osteoarthritic synovium in vitro: effects of hydrocortisone and indomethacin
    Clin Sci (Lond) (1981) 61, 703-710. PubMed  Europe PubMed
  148. Murphy,G., McGuire,M.B., Russell,R.G. and Reynolds,J.J.
    Characterization of collagenase, other metallo-proteinases and an inhibitor (TIMP) produced by human synovium and cartilage in culture
    Clin Sci (Lond) (1981) 61, 711-716. PubMed  Europe PubMed
  149. [YEAR:1-4-1981]Murphy,G., Cawston,T.E. and Reynolds,J.J.
    An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases
    Biochem J (1-4-1981) 195, 167-170. PubMed  Europe PubMed  PMC  EPMC
  150. [YEAR:16-11-1981]Sakamoto,S., Sakamoto,M., Matsumoto,A., Nagayama,M. and Glimcher,M.J.
    Chick bone collagenase inhibitor and latency of collagenase
    Biochem Biophys Res Commun (16-11-1981) 103, 339-346. PubMed  Europe PubMed
  151. Sellers,A. and Murphy,G.
    Collagenolytic enzymes and their naturally occurring inhibitors
    Int Rev Connect Tissue Res (1981) 9, 151-190. PubMed  Europe PubMed
  152. Yasui,N., Hori,H. and Nagai,Y.
    Production of collagenase inhibitor by the growth cartilage of embryonic chick bone: isolation and partial characterization
    Coll Relat Res (1981) 1, 59-72. PubMed  Europe PubMed
    153. 1980
  153. Cawston,T.E., Murphy,G., Galloway,W.A. and Reynolds,J.J.
    The binding of rabbit bone inhibitor of collagenase to concanavalin A-Sepharose
    Biochem Soc Trans (1980) 8, 112-113. PubMed  Europe PubMed
  154. [YEAR:1-10-1980]Kerwar,S.S., Nolan,J.C., Ridge,S.C., Oronsky,A.L. and Slakey,L.L.
    Properties of a collagenase inhibitor partially purified from cultures of smooth muscle cells
    Biochim Biophys Acta (1-10-1980) 632, 183-191. PubMed  Europe PubMed
    155. 1979
  155. [YEAR:30-3-1979]Sellers,A., Murphy,G., Meikle,M.C. and Reynolds,J.J.
    Rabbit bone collagenase inhibitor blocks the activity of other neutral metalloproteinases
    Biochem Biophys Res Commun (30-3-1979) 87, 581-587. PubMed  Europe PubMed
  156. [YEAR:25-4-1979]Vater,C.A., Mainardi,C.L. and Harris,E.D., Jr.
    Inhibitor of human collagenase from cultures of human tendon
    J Biol Chem (25-4-1979) 254, 3045-3053. PubMed  Europe PubMed
  157. [YEAR:25-3-1979]Welgus,H.G., Stricklin,G.P., Eisen,A.Z., Bauer,E.A., Cooney,R.V. and Jeffrey,J.J.
    A specific inhibitor of vertebrate collagenase produced by human skin fibroblasts
    J Biol Chem (25-3-1979) 254, 1938-1943. PubMed  Europe PubMed
    158. 1978
  158. [YEAR:12-1-1978]Woolley,D.E., Akroyd,C., Evanson,J.M., Soames,J.V. and Davies,R.M.
    Characterization and serum inhibition of neutral collagenase from cultured dog gingival tissue
    Biochim Biophys Acta (12-1-1978) 522, 205-217. PubMed  Europe PubMed
    159. 1977
  159. [YEAR:6-5-1977]Kuettner,K.E., Soble,L., Croxen,R.L., Marczynska,B., Hiti,J. and Harper,E.
    Tumor cell collagenase and its inhibition by a cartilage-derived protease inhibitor
    Science (6-5-1977) 196, 653-654. PubMed  Europe PubMed
  160. [YEAR:11-8-1977]Murphy,G., Cartwright,E.C., Sellers,A. and Reynolds,J.J.
    The detection and characterisation of collagenase inhibitors from rabbit tissues in culture
    Biochim Biophys Acta (11-8-1977) 483, 493-498. PubMed  Europe PubMed
  161. [YEAR:13-8-1977]Reynolds,J.J., Murphy,G., Sellers,A. and Cartwright,E.
    A new factor that may control collagen resorption
    Lancet (13-8-1977) 2, 333-335. PubMed  Europe PubMed
  162. [YEAR:1-11-1977]Sellers,A. and Reynolds,J.J.
    Identification and partial characterization of an inhibitor of collagenase from rabbit bone
    Biochem J (1-11-1977) 167, 353-360. PubMed  Europe PubMed  PMC  EPMC
    163. 1976
  163. [YEAR:27-5-1976]Woolley,D.E., Roberts,D.R. and Evanson,J.M.
    Small molecular weight beta 1 serum protein which specifically inhibits human collagenases
    Nature (27-5-1976) 261, 325-327. PubMed  Europe PubMed
    164. 1975
  164. McCroskery,P.A., Richards,J.F. and Harris,E.D., Jr.
    Purification and characterization of a collagenase extracted from rabbit tumours
    Biochem J (1975) 152, 131-142. PubMed  Europe PubMed  PMC  EPMC  I
  165. Woolley,D.E., Roberts,D.R. and Evanson,J.M.
    Inhibition of human collagenase activity by a small molecular weight serum protein
    Biochem Biophys Res Commun (1975) 66, 747-754. PubMed  Europe PubMed

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