Literature for I25.UPB: subfamily I25B unassigned peptidase inhibitors

Summary Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Yao,S., Zhang,R., Ma,S., Zhao,T., Liu,Q., Zhu,L., Liu,C., Sun,L. and Du,M.
    A Novel Cystatin Gene from Sea Cucumber (Apostichopus japonicus): Characterization and Comparative Expression with Cathepsin L During Early Stage of Hypoxic Exposure-Induced Autolysis
    Foods14, PubMed  Europe PubMed DOI
  2. 2024
  3. Acevedo,N., Lozano,A., Zakzuk,J., Llinas-Caballero,K., Brodin,D., Nejsum,P., Williams,A.R. and Caraballo,L.
    Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells
    Front Immunol15, 1328401-1328401. PubMed  Europe PubMed DOI
  4. 2023
  5. Fang,M., Cha,J.H., Wang,H.C., Ye,P., Chen,B., Chen,M., Yang,W.H. and Yan,X.
    An undefined cystatin CsCPI1 from tea plant Camellia sinensis harbors antithrombotic activity
    Biomed Pharmacother159, 114285-114285. PubMed  Europe PubMed DOI
  6. 2022
  7. Xu,S., Wang,Y., Han,C., Jiang,Y., Qin,Q. and Wei,S.
    Functional analysis of the Cystatin F gene response to SGIV infection in orange-spotted grouper, Epinephelus coioides
    Fish Shellfish Immunol130, 43-52. PubMed  Europe PubMed DOI
  8. 2021
  9. Caraballo,L., Zakzuk,J. and Acevedo,N.
    Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin
    Parasitology1-13. PubMed  Europe PubMed DOI  V
  10. Chen,Y., Wei,B., Xu,P., Tang,H., Yang,L., Wang,Y., Fu,Y., Yang,X. and Mao,Y.
    Schistosoma japonicum cystatin suppresses osteoclastogenesis via manipulating the NFkappaB signaling pathway
    Mol Med Rep23, 1-1. PubMed  Europe PubMed DOI
  11. Nie,J., Shan,N., Liu,H., Yao,X., Wang,Z., Bai,R., Guo,Y., Duan,Y., Wang,C. and Sui,X.
    Transcriptional control of local auxin distribution by the CsDFB1-CsPHB module regulates floral organogenesis in cucumber
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
  12. 2020
  13. [YEAR:1-6-2020]Schneider,V.K., da Silva Ferrara,T.F., Rocha,S.V., Santos-Júnior,C.D., Neo-Justino,D.M., da Cunha,A.F., de Oliveira da Silva JPM, Dos Santos Tersariol,I.L., Carmona,A.K., Henrique-Silva,F. and Soares-Costa,A.
    Recombinant expression, characterization and phylogenetic studies of novels cystatins-like proteins of sweet orange (Citrus sinensis) and clementine (Citrus clementina)
    Int J Biol Macromol152, 546-553. PubMed  Europe PubMed
  14. 2019
  15. Dong,X., Xu,J., Song,H., Liu,Y., Wu,M., Zhang,H., Jing,B., Lai,W., Gu,X., Xie,Y., Peng,X. and Yang,G.
    Molecular characterization of a Dirofilaria immitis cysteine protease inhibitor (cystatin) and its possible role in filarial immune evasion
    Genes (Basel)10, PubMed  Europe PubMed DOI
  16. 2018
  17. Christova,P.K., Christov,N.K., Mladenov,P.V. and Imai,R.
    The wheat multidomain cystatin TaMDC1 displays antifungal, antibacterial, and insecticidal activities in planta
    Plant Cell Rep37, 923-932. PubMed  Europe PubMed DOI
  18. Sanchez-Rodriguez,D.B., Ortega-Lopez,J., Cardenas-Guerra,R.E., Resendiz-Cardiel,G., Chavez-Munguia,B., Lagunes-Guillen,A. and Arroyo,R.
    Characterization of a novel endogenous cysteine proteinase inhibitor, trichocystatin-3 (TC-3), localized on the surface of Trichomonas vaginalis
    Int J Biochem Cell Biol102, 87-100. PubMed  Europe PubMed DOI
  19. 2017
  20. Li,H., Wang,S., Zhan,B., He,W., Chu,L., Qiu,D., Li,N., Wan,Y., Zhang,H., Chen,X., Fang,Q., Shen,J. and Yang,X.
    Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice
    Parasit Vectors10, 222-222. PubMed  Europe PubMed DOI  U
  21. Zavasnik-Bergant,T., Vidmar,R., Sekirnik,A., Fonovic,M., Salat,J., Grunclova,L., Kopacek,P. and Turk,B.
    Salivary tick cystatin OmC2 targets lysosomal cathepsins S and C in human dendritic cells
    Front Cell Infect Microbiol7, 288-288. PubMed  Europe PubMed DOI
  22. 2016
  23. Liu,F., Cheng,W., Pappoe,F., Hu,X., Wen,H., Luo,Q., Wang,S., Deng,F., Xie,Y., Xu,Y. and Shen,J.
    Schistosoma japonicum cystatin attenuates murine collagen-induced arthritis
    Parasitol Res115, 3795-3806. PubMed  Europe PubMed DOI
  24. 2015
  25. Lima,A.M., Dos Reis,S.P. and de Souza,C.R.
    Phytocystatins and their potential to control plant diseases caused by fungi
    Protein Pept Lett22, 104-111. PubMed  Europe PubMed  V
  26. Wan,H., Kang,T., Kim,B.Y., Lee,K.S., Li,J. and Jin,B.R.
    AvCystatin, a novel cysteine protease inhibitor from spider (Araneus ventricosus) venom
    J Asia-Pac Entomol18, 13-18. DOI
  27. Yadav,V.K., Mandal,R.S., Puniya,B.L., Kumar,R., Dey,S., Singh,S. and Yadav,S.
    Structural and binding studies of SAP-1 protein with heparin
    Chem Biol Drug Des85, 404-410. PubMed  Europe PubMed DOI
  28. 2014
  29. Chan,S.-N., Abu Bakar,N., Mahmood,M., Ho,C.-L. and Shaharuddin,N.A.
    Molecular cloning and characterization of novel phytocystatin gene from turmeric, Curcuma longa
    Biomed Res Int2014, Article ID 973790- PubMed  Europe PubMed DOI
  30. Geadkaew,A., Kosa,N., Siricoon,S., Grams,S.V. and Grams,R.
    A 170kDa multi-domain cystatin of Fasciola gigantica is active in the male reproductive system
    Mol Biochem Parasitol196, 100-107. PubMed  Europe PubMed DOI
  31. Je,J., Song,C., Hwang,J.E., Chung,W.S. and Lim,C.O.
    DREB2C acts as a transcriptional activator of the thermo tolerance-related phytocystatin 4 (AtCYS4) gene
    Transgenic Res23, 109-123. PubMed  Europe PubMed DOI
  32. Lin,S., Yuan,Y., Ren,X., Zou,J., Li,R., Guo,Y., Zhao,J. and Wang,R.
    Cloning and tissue expression of cysteine proteinase inhibitor (CPI) gene family in Nicotiana tabacum L
    Acta Tabacaria Sin20, 79-87. DOI
  33. Lu,S., Soares,T.S., Vaz Junior,I.S., Lovato,D.V. and Tanaka,A.S.
    Rmcystatin3, a cysteine protease inhibitor from Rhipicephalus microplus hemocytes involved in immune response
    Biochimie106, 17-23. PubMed  Europe PubMed DOI
  34. Puente-Rivera,J., de Los Angeles Ramon-Luing,L., Figueroa-Angulo,E.E., Ortega-Lopez,J. and Arroyo,R.
    Trichocystatin-2 (TC-2): an endogenous inhibitor of cysteine proteinases in Trichomonas vaginalis is associated with TvCP39
    Int J Biochem Cell Biol54, 255-265. PubMed  Europe PubMed DOI
  35. Yang,X., Liu,J., Yue,Y., Chen,W., Song,M., Zhan,X. and Wu,Z.
    Cloning, expression and characterisation of a type II cystatin from Schistosoma japonicum, which could regulate macrophage activation
    Parasitol Res113, 3985-3992. PubMed  Europe PubMed DOI
  36. Zhao,P., Zhou,X.M., Zou,J., Wang,W., Wang,L., Peng,X.B. and Sun,M.X.
    Comprehensive analysis of cystatin family genes suggests their putative functions in sexual reproduction, embryogenesis, and seed formation
    J Exp Bot65, 5093-5107. PubMed  Europe PubMed DOI
  37. 2013
  38. Imamura,S., Konnai,S., Yamada,S., Parizi,L.F., Githaka,N., Vaz,I.S., Jr., Murata,S. and Ohashi,K.
    Identification and partial characterization of a gut Rhipicephalus appendiculatus cystatin
    Ticks Tick Borne Dis4, 138-144. PubMed  Europe PubMed DOI
  39. Mohindra,V., Tripathi,R.K., Singh,A. and Singh,B.
    Molecular characterization and expression analysis of a novel cystatin-like gene in a hypoxia-tolerant Indian catfish, Clarias batrachus [Linnaeus, 1758]
    Fish Shellfish Immunol34, 683-687. PubMed  Europe PubMed DOI
  40. Parizi,L.F., Githaka,N.W., Acevedo,C., Benavides,U., Seixas,A., Logullo,C., Konnai,S., Ohashi,K., Masuda,A. and da Silva Vaz,I., Jr.
    Sequence characterization and immunogenicity of cystatins from the cattle tick Rhipicephalus (Boophilus) microplus
    Ticks Tick Borne Dis4, 492-499. PubMed  Europe PubMed DOI
  41. Porruana,R., Chundetb,R. and Anuntalabhochaia,S.
    Characterization of a cDNA encoding cystatin with antifungal activity from Siam tulip Curcuma alismatifolia
    ScienceAsia39, 596-604. DOI
  42. Raimbault,A.K., Zuily-Fodil,Y., Soler,A., Mora,P. and Cruz de Carvalho,M.H.
    The expression patterns of bromelain and AcCYS1 correlate with blackheart resistance in pineapple fruits submitted to postharvest chilling stress
    J Plant Physiol170, 1442-1446. PubMed  Europe PubMed DOI
  43. 2012
  44. Irene,D., Chung,T.Y., Chen,B.J., Liu,T.H., Li,F.Y., Tzen,J.T., Wang,C.I. and Chyan,C.L.
    Solution structure of a phytocystatin from Ananas comosus and its molecular interaction with papain
    PLoS ONE7, e47865-e47865. PubMed  Europe PubMed DOI  S
  45. 2011
  46. Buarque,D.S., Spindola,L.M., Martins,R.M., Braz,G.R. and Tanaka,A.S.
    Tigutcystatin, a cysteine protease inhibitor from Triatoma infestans midgut expressed in response to Trypanosoma cruzi
    Biochem Biophys Res Commun413, 241-247. PubMed  Europe PubMed DOI
  47. Gholizadeh,A. and Kohnehrouz,B.B.
    Functional fusion expression of sunflower multicystatin in E. coli and its comparison with a single domain cystatin
    Indian J Geo Mar Sci48, 375-379.  E
  48. Richards,R., St Pierre,L., Trabi,M., Johnson,L.A., de Jersey,J., Masci,P.P. and Lavin,M.F.
    Cloning and characterisation of novel cystatins from elapid snake venom glands
    Biochimie93, 659-668. PubMed  Europe PubMed DOI
  49. 2009
  50. Li,S., Ao,J. and Chen,X.
    Molecular and functional characterization of a cystatin analogue in large yellow croaker (Pseudosciaena crocea)
    Mol Immunol46, 1638-1646. PubMed  Europe PubMed DOI
  51. Martinez,M., Cambra,I., Carrillo,L., Diaz-Mendoza,M. and Diaz,I.
    Characterization of the entire cystatin gene family in barley and their target cathepsin L-like cysteine-proteases, partners in the hordein mobilization during seed germination
    Plant Physiol151, 1531-1545. PubMed  Europe PubMed DOI
  52. Neuteboom,L.W., Matsumoto,K.O. and Christopher,D.A.
    An extended AE-rich N-terminal trunk in secreted pineapple cystatin enhances inhibition of fruit bromelain and is posttranslationally removed during ripening
    Plant Physiol151, 515-527. PubMed  Europe PubMed DOI
  53. Yamaji,K., Tsuji,N., Miyoshi,T., Islam,M.K., Hatta,T., Alim,M.A., Anisuzzaman,M., Kushibiki,S. and Fujisaki,K.
    A salivary cystatin, HlSC-1, from the ixodid tick Haemaphysalis longicornis play roles in the blood-feeding processes
    Parasitol Res106, 61-68. PubMed  Europe PubMed DOI
  54. 2008
  55. Schnoeller,C., Rausch,S., Pillai,S., Avagyan,A., Wittig,B.M., Loddenkemper,C., Hamann,A., Hamelmann,E., Lucius,R. and Hartmann,S.
    A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages
    J Immunol180, 4265-4272. PubMed  Europe PubMed
  56. 2007
  57. Rodriguez-Mahillo,A.I., Gonzalez-Munoz,M., Gomez-Aguado,F., Rodriguez-Perez,R., Corcuera,M.T., Caballero,M.L. and Moneo,I.
    Cloning and characterisation of the Anisakis simplex allergen Ani s 4 as a cysteine-protease inhibitor
    Int J Parasitol37, 907-917. PubMed  Europe PubMed DOI
  58. 2006
  59. Christova,P.K., Christov,N.K. and Imai,R.
    A cold inducible multidomain cystatin from winter wheat inhibits growth of the snow mold fungus, Microdochium nivale
    Planta223, 1207-1218. PubMed  Europe PubMed DOI
  60. Grunclova,L., Horn,M., Vancova,M., Sojka,D., Franta,Z., Mares,M. and Kopacek,P.
    Two secreted cystatins of the soft tick Ornithodoros moubata: differential expression pattern and inhibitory specificity
    Biol Chem387, 1635-1644. PubMed  Europe PubMed DOI
  61. 2005
  62. [YEAR:9-8-2005]Pillai,S., Kalinna,B.H., Liebau,E., Hartmann,S., Theuring,F. and Lucius,R.
    Studies on Acanthocheilonema viteae cystatin: genomic organization, promoter studies and expression in Caenorhabditis elegans
    Filaria J4, 9-9. PubMed  Europe PubMed DOI
  63. 2004
  64. Shyu,D.J., Chyan,C.L., Tzen,J.T. and Chou,W.M.
    Molecular cloning, expression, and functional characterization of a cystatin from pineapple stem
    Biosci Biotechnol Biochem68, 1681-1689. PubMed  Europe PubMed DOI
  65. 2003
  66. Belenghi,B., Acconcia,F., Trovato,M., Perazzolli,M., Bocedi,A., Polticelli,F., Ascenzi,P. and Delledonne,M.
    AtCYS1, a cystatin from Arabidopsis thaliana, suppresses hypersensitive cell death
    Eur J Biochem270, 2593-2604. PubMed  Europe PubMed DOI
  67. [YEAR:31-1-2003]Sun,H., Li,N., Wang,X., Liu,S., Chen,T., Zhang,L., Wan,T. and Cao,X.
    Molecular cloning and characterization of a novel cystatin-like molecule, CLM, from human bone marrow stromal cells
    Biochem Biophys Res Commun301, 176-182. PubMed  Europe PubMed DOI
  68. 2002
  69. Vray,B., Hartmann,S. and Hoebeke,J.
    Immunomodulatory properties of cystatins
    Cell Mol Life Sci59, 1503-1512. PubMed  Europe PubMed DOI
  70. 2001
  71. Tzeng,S.S., Chen,G.H., Chung,Y.C. and Jiang,S.T.
    Expression of soluble form carp (Cyprinus carpio) ovarian cystatin in Escherichia coli and its purification
    J Agric Food Chem49, 4224-4230. PubMed  Europe PubMed DOI
  72. Ylonen,A., Kalkkinen,N., Saarinen,J., Bogwald,J. and Helin,J.
    Glycosylation analysis of two cysteine proteinase inhibitors from Atlantic salmon skin: di-O-acetylated sialic acids are the major sialic acid species on N-glycans
    Glycobiology11, 523-531. PubMed  Europe PubMed
  73. 1994
  74. Dickinson,D.P., Zhao,Y., Thiesse,M. and Siciliano,M.J.
    Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2
    Genomics24, 172-175. PubMed  Europe PubMed DOI
  75. 1987
  76. Ritonja,A., Evans,H.J., Machleidt,W. and Barrett,A.J.
    Amino acid sequence of a cystatin from venom of the African puff adder (Bitis arietans)
    Biochem J246, 799-802. PubMed  Europe PubMed
  77. 1979
  78. [YEAR:1-1-1979]Willadsen,P. and Riding,G.A.
    Characterization of a proteolytic-enzyme inhibitor with allergenic activity. Multiple functions of a parasite-derived protein
    Biochem J177, 41-47. PubMed  Europe PubMed