Literature for I25.UPA: subfamily I25A unassigned peptidase inhibitors

(Topics flags: S Structure, K Knockout, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026
1. Hong,W., Cheng,Z., Xu,Z., Zhong,S., Liu,X., Dibo,N., Dai,Z., Lin,Y., Lai,W., Jia,H., Shang,X. and Huang,S.
   Crystal structure of Echinococcus multilocularis cystatin B reveals a novel feature in classical stefins
   Sci Rep (2026) PubMed  Europe PubMed DOI
2025
2. Wang,Y.X., Ma,Y.D., Li,H.H., Duo,W.J., Jin,Q.W., Zhou,K.J., Gao,Y.R., He,J.N., Xie,Y.J., Chu,L. and Yang,X.D.
   Schistosoma japonicum cystatin attenuated CLP-induced sepsis in mice though inducing tolerogenic dendritic cells and regulatory T cells
   Comp Immunol Microbiol Infect Dis (2025) 120, 102345-102345. PubMed  Europe PubMed DOI
2024
3. Du,R., Zheng,X., Liu,Y., Lu,P., Hong,Y. and Wang,P.
   Molecular and functional characterization of a type-1 cystatin in amphioxus (Branchiostoma japonicum)
   Fish Shellfish Immunol (2024) 147, 109423-109423. PubMed  Europe PubMed DOI
2023
4. Busa,M., Matouskova,Z., Bartosova-Sojkova,P., Pachl,P., Rezacova,P., Eichenberger,R.M., Deplazes,P., Horn,M., Stefanic,S. and Mares,M.
   An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily
   J Biol Chem (2023) 299, 102970-102970. PubMed  Europe PubMed DOI  PMC  EPMC
2022
5. Zhang,K., Liu,Y., Zhang,G., Wang,X., Li,Z., Shang,Y., Ning,C., Ji,C., Cai,X., Xia,X., Qiao,J. and Meng,Q.
   Molecular Characteristics and Potent Immunomodulatory Activity of Fasciola hepatica Cystatin
   Korean J Parasitol (2022) 60, 117-126. PubMed  Europe PubMed DOI  PMC  EPMC
2021
6. Chen,Y., Wei,B., Xu,P., Tang,H., Yang,L., Wang,Y., Fu,Y., Yang,X. and Mao,Y.
   Schistosoma japonicum cystatin suppresses osteoclastogenesis via manipulating the NFkappaB signaling pathway
   Mol Med Rep (2021) 23, 1-1. PubMed  Europe PubMed DOI
7. Xie,H., Wu,L., Chen,X., Gao,S., Li,H., Yuan,Y., Liang,J., Wang,X., Wang,S., Xu,C., Chu,L., Zhan,B., Zhou,R. and Yang,X.
   Schistosoma japonicum Cystatin Alleviates Sepsis Through Activating Regulatory Macrophages
   Front Cell Infect Microbiol (2021) 11, 617461-617461. PubMed  Europe PubMed DOI  PMC  EPMC
2020
8. Kobpornchai,P., Flynn,R.J., Reamtong,O., Rittisoonthorn,N., Kosoltanapiwat,N., Boonnak,K., Boonyuen,U., Ampawong,S., Jiratanh,M., Tattiyapong,M. and Adisakwattana,P.
   A novel cystatin derived from Trichinella spiralis suppresses macrophage-mediated inflammatory responses
   PLoS Negl Trop Dis (2020) 14, e0008192-e0008192. PubMed  Europe PubMed DOI
9. Lu,S., da Rocha,L.A., Torquato,R.J.S., da Silva Vaz Junior,I., Florin-Christensen,M. and Tanaka,A.S.
   A novel type 1 cystatin involved in the regulation of Rhipicephalus microplus midgut cysteine proteases
   Ticks Tick Borne Dis (2020) , 101374-101374. PubMed  Europe PubMed DOI
10. Lu,S., Ascencio,M.E., Torquato,R.J.S., Florin-Christensen,M. and Tanaka,A.S.
    Kinetic characterization of a novel cysteine peptidase from the protozoan Babesia bovis, a potential target for drug design
    Biochimie (2020) 179, 127-134. PubMed  Europe PubMed DOI
11. Thai,T.L., Kang,J.M., Le,H.G., Lee,J., Yoo,W.G., Shin,H.J., Sohn,W.M. and Na,B.K.
    Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro
    Parasit Vectors (2020) 13, 41-41. PubMed  Europe PubMed DOI  PMC  EPMC
2019
12. Liu,J., Svard,S.G. and Klotz,C.
    Giardia intestinalis cystatin is a potent inhibitor of papain, parasite cysteine proteases and, to a lesser extent, human cathepsin B
    FEBS Lett (2019) 593, 1313-1325. PubMed  Europe PubMed DOI
13. Xu,J., Liu,M., Yu,P., Wu,L. and Lu,Y.
    Effect of recombinant Trichinella spiralis cysteine proteinase inhibitor on TNBS-induced experimental inflammatory bowel disease in mice
    Int Immunopharmacol (2019) 66, 28-40. PubMed  Europe PubMed DOI
14. Xue,Q. and Wu,X.Q.
    Characteristics and function of a novel cystatin gene in the pine wood nematode Bursaphelenchus xylophilus
    Biol Open (2019) 8 PubMed  Europe PubMed DOI
2018
15. Park,S.Y., Jeong,M.S., Park,S.A., Ha,S.C., Na,B.K. and Jang,S.B.
    Structural basis of the cystein protease inhibitor Clonorchis sinensis stefin-1
    Biochem Biophys Res Commun (2018) 498, 9-17. PubMed  Europe PubMed DOI  S
2017
16. Ilgova,J., Jedlickova,L., Dvorakova,H., Benovics,M., Mikes,L., Janda,L., Vorel,J., Roudnicky,P., Potesil,D., Zdrahal,Z., Gelnar,M. and Kasny,M.
    A novel type I cystatin of parasite origin with atypical legumain-binding domain
    Sci Rep (2017) 7, 17526-17526. PubMed  Europe PubMed DOI  PMC  EPMC
2016
17. Wang,S., Xie,Y., Yang,X., Wang,X., Yan,K., Zhong,Z., Wang,X., Xu,Y., Zhang,Y., Liu,F. and Shen,J.
    Therapeutic potential of recombinant cystatin from Schistosoma japonicum in TNBS-induced experimental colitis of mice
    Parasit Vectors (2016) 9, 6-6. PubMed  Europe PubMed DOI  PMC  EPMC  U
2014
18. Kang,J.M., Ju,H.L., Lee,K.H., Kim,T.S., Pak,J.H., Sohn,W.M. and Na,B.K.
    Identification and characterization of the second cysteine protease inhibitor of Clonorchis sinensis (CsStefin-2)
    Parasitol Res (2014) 113, 47-58. PubMed  Europe PubMed DOI
2013
19. Ibelli,A.M., Hermance,M.M., Kim,T.K., Gonzalez,C.L. and Mulenga,A.
    Bioinformatics and expression analyses of the Ixodes scapularis tick cystatin family
    Exp Appl Acarol (2013) 60, 41-53. PubMed  Europe PubMed DOI
20. Lee,J.Y., Song,S.M., Moon,E.K., Lee,Y.R., Jha,B.K., Danne,D.B., Cha,H.J., Yu,H.S., Kong,H.H., Chung,D.I. and Hong,Y.
    Cysteine protease inhibitor (AcStefin) is required for complete cyst formation of Acanthamoeba
    Eukaryot Cell (2013) 12, 567-574. PubMed  Europe PubMed DOI
2011
21. He,B., Cai,G., Ni,Y., Li,Y., Zong,H. and He,L.
    Characterization and expression of a novel cystatin gene from Schistosoma japonicum
    Mol Cell Probes (2011) 25, 186-193. PubMed  Europe PubMed DOI
22. Jang,S.W., Cho,M.K., Park,M.K., Kang,S.A., Na,B.K., Ahn,S.C., Kim,D.H. and Yu,H.S.
    Parasitic helminth cystatin inhibits DSS-induced intestinal inflammation via IL-10(+)F4/80(+) macrophage recruitment
    Korean J Parasitol (2011) 49, 245-254. PubMed  Europe PubMed DOI  PMC  EPMC
23. Kang,J.M., Lee,K.H., Sohn,W.M. and Na,B.K.
    Identification and functional characterization of CsStefin-1, a cysteine protease inhibitor of Clonorchis sinensis
    Mol Biochem Parasitol (2011) 177, 126-134. PubMed  Europe PubMed DOI
2010
24. Li,F., Gai,X., Wang,L., Song,L., Zhang,H., Qiu,L., Wang,M. and Siva,V.S.
    Identification and characterization of a cystatin gene from Chinese mitten crab Eriocheir sinensis
    Fish Shellfish Immunol (2010) 29, 521-529. PubMed  Europe PubMed DOI
2009
25. Bilodeau,M., MacRae,T., Gaboury,L., Laverdure,J.P., Hardy,M.P., Mayotte,N., Paradis,V., Harton,S., Perreault,C. and Sauvageau,G.
    Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1
    PLoS ONE (2009) 4, e7500-e7500. PubMed  Europe PubMed DOI  PMC  EPMC  K
26. Tarasuk,M., Vichasri Grams,S., Viyanant,V. and Grams,R.
    Type I cystatin (stefin) is a major component of Fasciola gigantica excretion/secretion product
    Mol Biochem Parasitol (2009) 167, 60-71. PubMed  Europe PubMed DOI
27. Zhou,J., Liao,M., Ueda,M., Gong,H., Xuan,X. and Fujisaki,K.
    Characterization of an intracellular cystatin homolog from the tick Haemaphysalis longicornis
    Vet Parasitol (2009) 160, 180-183. PubMed  Europe PubMed DOI
2006
28. [YEAR:12-6-2006]Lima,C.A., Sasaki,S.D. and Tanaka,A.S.
    Bmcystatin, a cysteine proteinase inhibitor characterized from the tick Boophilus microplus
    Biochem Biophys Res Commun (12-6-2006) 347, 44-50. PubMed  Europe PubMed DOI
2004
29. El-Halawany,M.S., Ohkouchi,S., Shibata,H., Hitomi,K. and Maki,M.
    Identification of cysteine protease inhibitors that belong to cystatin family 1 in the cellular slime mold Dictyostelium discoideum
    Biol Chem (2004) 385, 547-550. PubMed  Europe PubMed DOI
2001
30. Ichikawa,K., Vailes,L.D., Pom's,A. and Chapman,M.D.
    Molecular cloning, expression and modelling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor
    Clin Exp Allergy (2001) 31, 1279-1286. PubMed  Europe PubMed DOI
1996
31. Lenarcic,B., Krizaj,I., Zunec,P. and Turk,V.
    Differences in specificity for the interactions of stefins A, B and D with cysteine proteinases
    FEBS Lett (1996) 395, 113-118. PubMed  Europe PubMed DOI