Literature for inhibitor I25.006: cystatin 6

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024
1. Gai,D., Caviness,P.C., Lazarenko,O.P., Chen,J.F., Randolph,C.E., Zhang,Z., Cheng,Y., Sun,F., Xu,H., Blackburn,M.L., Tricot,G., Shaughnessy,J.D., Jr., Chen,J.R. and Zhan,F.
   Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx
   Res Sq PubMed  Europe PubMed DOI
2022
2. Gai,D., Chen,J.R., Stewart,J.P., Nookaew,I., Habelhah,H., Ashby,C., Sun,F., Cheng,Y., Li,C., Xu,H., Peng,B., Garg,T.K., Schinke,C., Thanendrarajan,S., Zangari,M., Chen,F., Barlogie,B., van Rhee,F., Tricot,G., Shaughnessy,J.D., Jr. and Zhan,F.
   CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
   J Clin Invest132, PubMed  Europe PubMed DOI
2021
3. Eckl,K.M., Gruber,R., Brennan,L., Marriott,A., Plank,R., Moosbrugger-Martinz,V., Blunder,S., Schossig,A., Altmuller,J., Thiele,H., Nurnberg,P., Zschocke,J., Hennies,H.C. and Schmuth,M.
   Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V
   Front Genet12, 689940-689940. PubMed  Europe PubMed DOI
4. Lalmanach,G., Kasabova-Arjomand,M., Lecaille,F. and Saidi,A.
   Cystatin M/E (Cystatin 6): A Janus-Faced Cysteine Protease Inhibitor with Both Tumor-Suppressing and Tumor-Promoting Functions
   Cancers (Basel)13, PubMed  Europe PubMed DOI
5. Xu,D., Ding,S., Cao,M., Yu,X., Wang,H., Qiu,D., Xu,Z., Bi,X., Mu,Z. and Li,K.
   A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors
   Front Genet12, 733211-733211. PubMed  Europe PubMed DOI
2019
6. van den Bogaard,E.H.J., van Geel,M., van Vlijmen-Willems,I.M.J.J., Jansen,P.A.M., Peppelman,M., van Erp,P.E.J., Atalay,S., Venselaar,H., Simon,M.E.H., Joosten,M., Schalkwijk,J. and Zeeuwen,P.L.J.M.
   Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin
   Genet Med21, 1559-1567. PubMed  Europe PubMed DOI
2018
7. Dall,E., Hollerweger,J.C., Dahms,S.O., Cui,H., Haussermann,K. and Brandstetter,H.
   Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states
   J Biol Chem293, 13151-13165. PubMed  Europe PubMed DOI
2017
8. Oortveld,M.A.W., van Vlijmen-Willems,I.M.J.J., Kersten,F.F.J., Cheng,T., Verdoes,M., van Erp,P.E.J., Verbeek,S., Reinheckel,T., Hendriks,W.J.A.J., Schalkwijk,J. and Zeeuwen,P.L.J.M.
   Cathepsin B as a potential cystatin M/E target in the mouse hair follicle
   FASEB J31, 4286-4294. PubMed  Europe PubMed DOI  K
9. Wallin,H., Apelqvist,J., Andersson,F., Ekstrom,U. and Abrahamson,M.
   Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells
   J Biol Chem292, 14413-14424. PubMed  Europe PubMed DOI
2016
10. Soh,H., Venkatesan,N., Veena,M.S., Ravichandran,S., Zinabadi,A., Basak,S.K., Parvatiyar,K., Srivastava,M., Liang,L.J., Gjertson,D.W., Torres,J.Z., Moatamed,N.A. and Srivatsan,E.S.
    Cystatin E/M suppresses tumor cell growth through cytoplasmic retention of NF-kappaB
    Mol Cell Biol36, 1776-1792. PubMed  Europe PubMed DOI
2015
11. Dall,E., Fegg,J.C., Briza,P. and Brandstetter,H.
    Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain
    Angew Chem Int Ed Engl54, 2917-2921. PubMed  Europe PubMed DOI  S
2014
12. D'Costa,Z.C., Higgins,C., Ong,C.W., Irwin,G.W., Boyle,D., McArt,D.G., McCloskey,K., Buckley,N.E., Crawford,N.T., Thiagarajan,L., Murray,J.T., Kennedy,R.D., Mulligan,K.A., Harkin,D.P., Waugh,D.J.J., Scott,C.J., Salto-Tellez,M., Williams,R. and Mullan,P.B.
    TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities
    Oncotarget5, 1609-1620. PubMed  Europe PubMed
13. Zhao,Y.-M., He,W., Wang,F., Zhao,G.-Q., Ye,Y.-W. and Fan,Q.-X.
    Cystatin M inhibits the proliferation and migration of gastric cancer SGC-7901 cell lines
    J Xi'An Jiaotong Univ Med Sci35, 375-379. DOI
2012
14. Jansen,P.A.M., van den Bogaard,E.H., Kersten,F.F.J., Oostendorp,C., van Vlijmen-Willems,I.M.J.J., Oji,V., Traupe,H., Hennies,H.C., Schalkwijk,J. and Zeeuwen,P.L.J.M.
    Cystatin M/E knockdown by lentiviral delivery of shRNA impairs epidermal morphogenesis of human skin equivalents
    Exp Dermatol21, 889-891. PubMed  Europe PubMed DOI  K  M
15. Smith,R., Johansen,H.T., Nilsen,H., Haugen,M.H., Pettersen,S.J., Maelandsmo,G.M., Abrahamson,M. and Solberg,R.
    Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M
    Biochimie94, 2590-2599. PubMed  Europe PubMed DOI
2010
16. Briggs,J.J., Haugen,M.H., Johansen,H.T., Riker,A.I., Abrahamson,M., Fodstad,O., Maelandsmo,G.M. and Solberg,R.
    Cystatin E/M suppresses legumain activity and invasion of human melanoma
    BMC Cancer10, 17-17. PubMed  Europe PubMed DOI
17. Zeeuwen,P.L., van Vlijmen-Willems,I.M., Cheng,T., Rodijk-Olthuis,D., Hitomi,K., Hara-Nishimura,I., John,S., Smyth,N., Reinheckel,T., Hendriks,W.J. and Schalkwijk,J.
    The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea
    FASEB J24, 3744-3755. PubMed  Europe PubMed DOI  K
2009
18. Cheng,T., Tjabringa,G.S., van Vlijmen-Willems,I.M., Hitomi,K., van Erp,P.E., Schalkwijk,J. and Zeeuwen,P.L.
    The cystatin M / E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis
    Br J Dermatol161, 253-264. PubMed  Europe PubMed DOI
19. Cheng,T., van Vlijmen-Willems,I.M., Hitomi,K., Pasch,M.C., van Erp,P.E., Schalkwijk,J. and Zeeuwen,P.L.
    Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail
    J Invest Dermatol129, 1232-1242. PubMed  Europe PubMed DOI
20. Kioulafa,M., Balkouranidou,I., Sotiropoulou,G., Kaklamanis,L., Mavroudis,D., Georgoulias,V. and Lianidou,E.S.
    Methylation of cystatin M promoter is associated with unfavorable prognosis in operable breast cancer
    Int J Cancer125, 2887-2892. PubMed  Europe PubMed DOI
21. Pulukuri,S.M., Gorantla,B., Knost,J.A. and Rao,J.S.
    Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer
    Oncogene28, 2829-2838. PubMed  Europe PubMed DOI
22. Zeeuwen,P.L., Cheng,T. and Schalkwijk,J.
    The biology of cystatin M/E and its cognate target proteases
    J Invest Dermatol129, 1327-1338. PubMed  Europe PubMed DOI  V
2008
23. Hosokawa,M., Kashiwaya,K., Eguchi,H., Ohigashi,H., Ishikawa,O., Furihata,M., Shinomura,Y., Imai,K., Nakamura,Y. and Nakagawa,H.
    Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth
    Cancer Sci99, 1626-1632. PubMed  Europe PubMed DOI
24. Qiu,J., Ai,L., Ramachandran,C., Yao,B., Gopalakrishnan,S., Fields,C.R., Delmas,A.L., Dyer,L.M., Melnick,S.J., Yachnis,A.T., Schwartz,P.H., Fine,H.A., Brown,K.D. and Robertson,K.D.
    Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas
    Lab Invest88, 910-925. PubMed  Europe PubMed DOI
25. Veena,M.S., Lee,G., Keppler,D., Mendonca,M.S., Redpath,J.L., Stanbridge,E.J., Wilczynski,S.P. and Srivatsan,E.S.
    Inactivation of the cystatin E/M tumor suppressor gene in cervical cancer
    Genes Chromosomes Cancer47, 740-754. PubMed  Europe PubMed DOI
2007
26. Schagdarsurengin,U., Pfeifer,G.P. and Dammann,R.
    Frequent epigenetic inactivation of cystatin M in breast carcinoma
    Oncogene26, 3089-3094. PubMed  Europe PubMed DOI
27. Zeeuwen,P.L., Ishida-Yamamoto,A., van Vlijmen-Willems,I.M., Cheng,T., Bergers,M., Iizuka,H. and Schalkwijk,J.
    Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation
    J Invest Dermatol127, 120-128. PubMed  Europe PubMed DOI
2006
28. [YEAR:15-8-2006]Ai,L., Kim,W.J., Kim,T.Y., Fields,C.R., Massoll,N.A., Robertson,K.D. and Brown,K.D.
    Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression
    Cancer Res66, 7899-7909. PubMed  Europe PubMed DOI
29. [YEAR:24-3-2006]Cheng,T., Hitomi,K., van Vlijmen-Willems,I.M., de Jongh,G.J., Yamamoto,K., Nishi,K., Watts,C., Reinheckel,T., Schalkwijk,J. and Zeeuwen,P.L.
    Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification
    J Biol Chem281, 15893-15899. PubMed  Europe PubMed DOI
30. [YEAR:6-9-2006]Vigneswaran,N., Wu,J., Nagaraj,N., James,R., Zeeuwen,P. and Zacharias,W.
    Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion
    Life Sci78, 898-907. PubMed  Europe PubMed DOI
2004
31. [YEAR:15-12-2004]Shridhar,R., Zhang,J., Song,J., Booth,B.A., Kevil,C.G., Sotiropoulou,G., Sloane,B.F. and Keppler,D.
    Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells
    Oncogene23, 2206-2215. PubMed  Europe PubMed DOI
32. [YEAR:15-5-2004]Zeeuwen,P.L., van Vlijmen-Willems,I.M., Olthuis,D., Johansen,H.T., Hitomi,K., Hara-Nishimura,I., Powers,J.C., James,K.E., Op den Camp,H.J., Lemmens,R. and Schalkwijk,J.
    Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice
    Hum Mol Genet13, 1069-1079. PubMed  Europe PubMed DOI
33. [YEAR:1-10-2004]Zhang,J., Shridhar,R., Dai,Q., Song,J., Barlow,S.C., Yin,L., Sloane,B.F., Miller,F.R., Meschonat,C., Li,B.D., Abreo,F. and Keppler,D.
    Cystatin M: a novel candidate tumor suppressor gene for breast cancer
    Cancer Res64, 6957-6964. PubMed  Europe PubMed DOI
2003
34. Vigneswaran,N., Wu,J. and Zacharias,W.
    Upregulation of cystatin M during the progression of oropharyngeal squamous cell carcinoma from primary tumor to metastasis
    Oral Oncol39, 559-568. PubMed  Europe PubMed DOI
35. Zeeuwen,P.L., Dale,B.A., de Jongh,G.J., van Vlijmen-Willems,I.M., Fleckman,P., Kimball,J.R., Stephens,K. and Schalkwijk,J.
    The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis
    J Invest Dermatol121, 65-68. PubMed  Europe PubMed DOI
2002
36. Hong,J., Yoshida,K. and Rosner,M.R.
    Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation
    J Neurochem81, 922-934. PubMed  Europe PubMed DOI
37. [YEAR:1-11-2002]Zeeuwen,P.L., van Vlijmen-Willems,I.M., Hendriks,W., Merkx,G.F. and Schalkwijk,J.
    A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification
    Hum Mol Genet11, 2867-2875. PubMed  Europe PubMed  M
38. Zeeuwen,P.L., van Vlijmen-Willems,I.M., Egami,H. and Schalkwijk,J.
    Cystatin M/E expression in inflammatory and neoplastic skin disorders
    Br J Dermatol147, 87-94. PubMed  Europe PubMed DOI
2001
39. Zeeuwen,P.L., van Vlijmen-Willems,I.M., Jansen,B.J., Sotiropoulou,G., Curfs,J.H., Meis,J.F., Janssen,J.J., Van Ruissen,F. and Schalkwijk,J.
    Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase
    J Invest Dermatol116, 693-701. PubMed  Europe PubMed DOI
1999
40. [YEAR:2-7-1999]Alvarez-Fernandez,M., Barrett,A.J., Gerhartz,B., Dando,P.M., Ni,J. and Abrahamson,M.
    Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site
    J Biol Chem274, 19195-19203. PubMed  Europe PubMed DOI
1997
41. Ni,J., Abrahamson,M., Zhang,M., Fernandez,M.A., Grubb,A., Su,J., Yu,G.L., Li,Y., Parmelee,D., Xing,L., Coleman,T.A., Gentz,S., Thotakura,R., Nguyen,N., Hesselberg,M. and Gentz,R.
    Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins
    J Biol Chem272, 10853-10858. PubMed  Europe PubMed DOI
42. Sotiropoulou,G., Anisowicz,A. and Sager,R.
    Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer
    J Biol Chem272, 903-910. PubMed  Europe PubMed DOI