Literature for inhibitor I17.002: elafin

(Topics flags: S Structure, M Mutation, P Specificity, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2023
1. Deraison,C., Bonnart,C., Langella,P., Roget,K. and Vergnolle,N.
   Elafin and its precursor trappin-2: What is their therapeutic potential for intestinal diseases?
   Br J Pharmacol180, 144-160. PubMed  Europe PubMed DOI
2. Lee,S., Yoo,I., Cheon,Y. and Ka,H.
   Spatiotemporal expression and regulation of peptidase inhibitor 3 and secretory leukocyte protease inhibitor at the maternal-fetal interface in pigs
   Anim Biosci36, 1034-1043. PubMed  Europe PubMed DOI
2022
3. Wang,C., Liao,Y., He,W., Zhang,H., Zuo,D., Liu,W., Yang,Z., Qiu,J., Yuan,Y., Li,K., Zhang,Y., Wang,Y., Shi,Y., Qiu,Y., Gao,S., Yuan,Y. and Li,B.
   Correction to: Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma
   J Exp Clin Cancer Res41, 104-104. PubMed  Europe PubMed DOI
2021
4. Douglas,T.C. and Hannila,S.S.
   Working from within: how secretory leukocyte protease inhibitor regulates the expression of pro-inflammatory genes
   Biochem Cell Biol PubMed  Europe PubMed DOI  V
2020
5. Curciarello,R., Sobande,T., Jones,S., Giuffrida,P., Di Sabatino,A., Docena,G.H., Macdonald,T.T. and Kok,K.
   Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies
   J Inflamm Res13, 233-243. PubMed  Europe PubMed DOI
6. Shu,L., Zhong,L., Xiao,Y., Wu,X., Liu,Y., Jiang,X., Tang,T., Hoo,R., Zhou,Z. and Xu,A.
   Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice
   Clin Sci (Lond)134, 1679-1696. PubMed  Europe PubMed DOI
2019
7. Geusau,A., Tzaneva,S., Petzelbauer,P., Mullegger,R., Brunner,P.M., Borik,L. and Mildner,M.
   Peptidase inhibitor 3 and chemokine ligand 27 may serve as biomarkers for actinic keratoses in organ transplant recipients
   Eur J Dermatol29, 259-267. PubMed  Europe PubMed DOI
2017
8. Han,W., Li,X., Zhang,H., Yu,B., Guo,C. and Deng,C.
   Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia
   Int J Biochem Cell Biol92, 173-182. PubMed  Europe PubMed DOI  U
9. Small,D.M., Doherty,D.F., Dougan,C.M., Weldon,S. and Taggart,C.C.
   The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease
   Biol Chem398, 425-440. PubMed  Europe PubMed DOI
2016
10. Kaschwich,M., Lutzen,U., Zhao,Y., Tjiong,A., Marx,M., Haenisch,S., Wiedow,O., Preuss,S., Culman,J. and Zuhayra,M.
    Biodistribution and pharmacokinetics of the (99m)Tc labeled human elastase inhibitor, elafin, in rats
    Drug Metab Pharmacokinet31, 146-155. PubMed  Europe PubMed DOI  U
11. Loth,K., Alami,S.A., Habes,C., Garrido,S., Aucagne,V., Delmas,A.F., Moreau,T., Zani,M.L. and Landon,C.
    Complete 1H, 15N and 13C assignment of trappin-2 and (1)H assignment of its two domains elafin and cementoin
    Biomol NMR Assign10, 223-226. PubMed  Europe PubMed DOI  S
12. Muto,J., Fujimoto,N., Ono,K., Kobayashi,T., Chen,K.R., Suzuki,S., Wachi,H. and Tajima,S.
    Deposition of elafin in the involved vascular wall of neutrophil-mediated cutaneous vasculitis
    J Eur Acad Dermatol Venereol30, 1544-1549. PubMed  Europe PubMed DOI
2015
13. Alam,S.R., Lewis,S.C., Zamvar,V., Pessotto,R., Dweck,M.R., Krishan,A., Goodman,K., Oatey,K., Harkess,R., Milne,L., Thomas,S., Mills,N.M., Moore,C., Semple,S., Wiedow,O., Stirrat,C., Mirsadraee,S., Newby,D.E. and Henriksen,P.A.
    Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery: a randomised-controlled trial
    Heart101, 1639-1645. PubMed  Europe PubMed DOI  U
14. Caruso,J.A., Akli,S., Pageon,L., Hunt,K.K. and Keyomarsi,K.
    The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase
    Oncogene34, 3556-3567. PubMed  Europe PubMed DOI
15. Chun,H.J. and Yu,P.B.
    Elafin in pulmonary arterial hypertension. Beyond targeting elastases
    Am J Respir Crit Care Med191, 1217-1219. PubMed  Europe PubMed DOI  U
16. Feng,Y., Doberstein,K. and Drapkin,R.
    Elafin: a double agent in breast and ovarian cancer
    Oncoscience2, 793-794. PubMed  Europe PubMed DOI
17. Jiang,X., Nguyen,T.T., Tian,W., Sung,Y.K., Yuan,K., Qian,J., Rajadas,J., Sallenave,J.M., Nickel,N.P., de Jesus Perez,V., Rabinovitch,M. and Nicolls,M.R.
    Cyclosporine does not prevent microvascular loss in transplantation but can synergize with a neutrophil elastase inhibitor, elafin, to maintain graft perfusion during acute rejection
    Am J Transplant15, 1768-1781. PubMed  Europe PubMed DOI  U
18. Kav,T.
    Use of elafin in celiac disease
    Turk J Gastroenterol26, 93-94. PubMed  Europe PubMed DOI  U
19. Small,D.M., Zani,M.L., Quinn,D.J., Dallet-Choisy,S., Glasgow,A.M., O'Kane,C., McAuley,D.F., McNally,P., Weldon,S., Moreau,T. and Taggart,C.C.
    A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation
    Mol Ther23, 24-31. PubMed  Europe PubMed DOI  U
2014
20. Galipeau,H.J., Wiepjes,M., Motta,J.P., Schulz,J.D., Jury,J., Natividad,J.M., Pinto-Sanchez,I., Sinclair,D., Rousset,P., Martin-Rosique,R., Bermudez-Humaran,L., Leroux,J.C., Murray,J.A., Smecuol,E., Bai,J.C., Vergnolle,N., Langella,P. and Verdu,E.F.
    Novel role of the serine protease inhibitor elafin in gluten-related disorders
    Am J Gastroenterol109, 748-756. PubMed  Europe PubMed DOI
21. Tejera,P., O'Mahony,D.S., Owen,C.A., Wei,Y., Wang,Z., Gupta,K., Su,L., Villar,J., Wurfel,M. and Christiani,D.C.
    Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome
    Am J Respir Cell Mol Biol51, 262-272. PubMed  Europe PubMed DOI  M
2012
22. Greenhill,C.
    IBD: elafin - a potential IBD therapy
    Nat Rev Gastroenterol Hepatol9, 686-686. PubMed  Europe PubMed DOI  U
23. Hilgendorff,A., Parai,K., Ertsey,R., Juliana Rey-Parra,G., Thebaud,B., Tamosiuniene,R., Jain,N., Navarro,E.F., Starcher,B.C., Nicolls,M.R., Rabinovitch,M. and Bland,R.D.
    Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth
    Am J Physiol Lung Cell Mol Physiol303, L215-L227. PubMed  Europe PubMed DOI
2011
24. Hilgendorff,A., Parai,K., Ertsey,R., Jain,N., Navarro,E.F., Peterson,J.L., Tamosiuniene,R., Nicolls,M.R., Starcher,B.C., Rabinovitch,M. and Bland,R.D.
    Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice
    Am J Respir Crit Care Med184, 537-546. PubMed  Europe PubMed DOI  U
25. Scott,A., Weldon,S. and Taggart,C.C.
    SLPI and elafin: multifunctional antiproteases of the WFDC family
    Biochem Soc Trans39, 1437-1440. PubMed  Europe PubMed DOI
26. Shaw,L. and Wiedow,O.
    Therapeutic potential of human elafin
    Biochem Soc Trans39, 1450-1454. PubMed  Europe PubMed DOI  U
27. Xu,X.Y., Yuan,D.M. and Zhou,X.D.
    [Effects of recombinant human elafin gene transfection on lipopolysaccharide-induced airway mucous hypersecretion]
    Zhonghua Yi Xue Za Zhi91, 340-344. PubMed  Europe PubMed  U
28. Yu,H.M., Li,Q., Zhou,X.D., Perelman,J.M. and Kolosov,V.P.
    Expression of recombinant fusion protein BoNT-LH (N)-elafin in Pichia pastoris and activity of expressed product
    Chin J Biol24, 389-393.  U
29. Zani,M.L., Tanga,A., Saidi,A., Serrano,H., Dallet-Choisy,S., Baranger,K. and Moreau,T.
    SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions
    Biochem Soc Trans39, 1441-1446. PubMed  Europe PubMed DOI  U
2010
30. Caruso,J.A., Hunt,K.K. and Keyomarsi,K.
    The neutrophil elastase inhibitor elafin triggers Rb-mediated growth arrest and caspase-dependent apoptosis in breast cancer
    Cancer Res70, 7125-7136. PubMed  Europe PubMed DOI
31. Clauss,A., Ng,V., Liu,J., Piao,H., Russo,M., Vena,N., Sheng,Q., Hirsch,M.S., Bonome,T., Matulonis,U., Ligon,A.H., Birrer,M.J. and Drapkin,R.
    Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival
    Neoplasia12, 161-172. PubMed  Europe PubMed DOI
32. Guyot,N., Bergsson,G., Butler,M.W., Greene,C.M., Weldon,S., Kessler,E., Levine,R.L., O'Neill,S.J., Taggart,C.C. and McElvaney,N.G.
    Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases
    Biol Chem391, 705-716. PubMed  Europe PubMed DOI  P
33. Li,Q., Zhou,X.D., Xu,X.Y. and Yang,J.
    Recombinant human elafin protects airway epithelium integrity during inflammation
    Mol Biol Rep37, 2981-2988. PubMed  Europe PubMed DOI  U
34. Li,Q., Zhou,X., Nie,X. and Yang,J.
    The role of recombinant human elafin in the resistance of A549 cells against Pseudomonas aeruginosa biofilm
    Respiration79, 68-75. PubMed  Europe PubMed DOI
35. Sallenave,J.M.
    Secretory leukocyte protease inhibitor and elafin/trappin-2: versatile mucosal antimicrobials and regulators of immunity
    Am J Respir Cell Mol Biol42, 635-643. PubMed  Europe PubMed DOI  V
36. Yu,K.S., Lee,Y., Kim,C.M., Park,E.C., Choi,J., Lim,D.S., Chung,Y.H. and Koh,S.S.
    The protease inhibitor, elafin, induces p53-dependent apoptosis in human melanoma cells
    Int J Cancer127, 1308-1320. PubMed  Europe PubMed DOI
2009
37. Iqbal,S.M., Ball,T.B., Levinson,P., Maranan,L., Jaoko,W., Wachihi,C., Pak,B.J., Podust,V.N., Broliden,K., Hirbod,T., Kaul,R. and Plummer,F.A.
    Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition
    AIDS23, 1669-1677. PubMed  Europe PubMed DOI
38. Marischen,L., Wesch,D., Schroder,J.M., Wiedow,O. and Kabelitz,D.
    Human gammadelta T cells produce the protease inhibitor and antimicrobial peptide elafin
    Scand J Immunol70, 547-552. PubMed  Europe PubMed DOI
39. Tejera,P., Wang,Z., Zhai,R., Su,L., Sheu,C.C., Taylor,D.M., Chen,F., Gong,M.N., Thompson,B.T. and Christiani,D.C.
    Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome
    Am J Respir Cell Mol Biol41, 696-704. PubMed  Europe PubMed DOI  M
2008
40. Baranger,K., Zani,M.L., Chandenier,J., Dallet-Choisy,S. and Moreau,T.
    The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function
    FEBS J275, 2008-2020. PubMed  Europe PubMed DOI
41. Bellemare,A., Vernoux,N., Morisset,D. and Bourbonnais,Y.
    Human pre-elafin inhibits a Pseudomonas aeruginosa-secreted peptidase and prevents its proliferation in complex media
    Antimicrob Agents Chemother52, 483-490. PubMed  Europe PubMed DOI
42. Moreau,T., Baranger,K., Dade,S., Dallet-Choisy,S., Guyot,N. and Zani,M.L.
    Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family
    Biochimie90, 284-295. PubMed  Europe PubMed DOI
2007
43. Doucet,A., Bouchard,D., Janelle,M.F., Bellemare,A., Gagne,S., Tremblay,G.M. and Bourbonnais,Y.
    Characterization of human pre-elafin mutants: full antipeptidase activity is essential to preserve lung tissue integrity in experimental emphysema
    Biochem J405, 455-463. PubMed  Europe PubMed DOI
44. Muto,J., Kuroda,K., Wachi,H., Hirose,S. and Tajima,S.
    Accumulation of elafin in actinic elastosis of sun-damaged skin: elafin binds to elastin and prevents elastolytic degradation
    J Invest Dermatol127, 1358-1366. PubMed  Europe PubMed DOI
2006
45. [YEAR:15-9-2006]Butler,M.W., Robertson,I., Greene,C.M., O'Neill,S.J., Taggart,C.C. and McElvaney,N.G.
    Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappa B activation via an effect on the ubiquitin-proteasome pathway
    J Biol Chem281, 34730-34735. PubMed  Europe PubMed DOI
46. Janelle,M.F., Doucet,A., Bouchard,D., Bourbonnais,Y. and Tremblay,G.M.
    Increased local levels of granulocyte colony-stimulating factor are associated with the beneficial effect of pre-elafin (SKALP/trappin-2/WAP3) in experimental emphysema
    Biol Chem387, 903-909. PubMed  Europe PubMed DOI
47. [YEAR:19-1-2006]Roghanian,A., Williams,S.E., Sheldrake,T.A., Brown,T.I., Oberheim,K., Xing,Z., Howie,S.E. and Sallenave,J.M.
    The antimicrobial/elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity
    Am J Respir Cell Mol Biol34, 634-642. PubMed  Europe PubMed DOI
2005
48. Guyot,N., Zani,M.L., Berger,P., Dallet-Choisy,S. and Moreau,T.
    Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin
    Biol Chem386, 391-399. PubMed  Europe PubMed DOI
49. [YEAR:29-11-2005]Guyot,N., Zani,M.L., Maurel,M.C., Dallet-Choisy,S. and Moreau,T.
    Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase
    Biochemistry44, 15610-15618. PubMed  Europe PubMed DOI
50. Nobar,S.M., Zani,M.L., Boudier,C., Moreau,T. and Bieth,J.G.
    Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3
    FEBS J272, 5883-5893. PubMed  Europe PubMed DOI
2004
51. [YEAR:3-8-2004]Brown,T.I., Mistry,R., Collie,D.D., Tate,S. and Sallenave,J.M.
    Trappin ovine molecule (TOM), the ovine ortholog of elafin, is an acute phase reactant in the lung
    Physiol Genomics19, 11-21. PubMed  Europe PubMed DOI
52. [YEAR:10-9-2004]Henriksen,P.A., Devitt,A., Kotelevtsev,Y. and Sallenave,J.M.
    Gene delivery of the elastase inhibitor elafin protects macrophages from neutrophil elastase-mediated impairment of apoptotic cell recognition
    FEBS Lett574, 80-84. PubMed  Europe PubMed DOI
53. Ohta,K., Nakajima,T., Cheah,A.Y., Zaidi,S.H., Kaviani,N., Dawood,F., You,X.M., Liu,P., Husain,M. and Rabinovitch,M.
    Elafin-overexpressing mice have improved cardiac function after myocardial infarction
    Am J Physiol Heart Circ Physiol287, H286-H292. PubMed  Europe PubMed DOI
54. Zani,M.L., Nobar,S.M., Lacour,S.A., Lemoine,S., Boudier,C., Bieth,J.G. and Moreau,T.
    Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris
    Eur J Biochem271, 2370-2378. PubMed  Europe PubMed DOI
2003
55. King,A.E., Critchley,H.O., Sallenave,J.M. and Kelly,R.W.
    Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruation
    J Clin Endocrinol Metab88, 4426-4431. PubMed  Europe PubMed DOI
2002
56. [YEAR:15-11-2002]Clauss,A., Lilja,H. and Lundwall,A.
    A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein
    Biochem J368, 233-242. PubMed  Europe PubMed DOI
57. Sallenave,J.M.
    Antimicrobial activity of antiproteinases
    Biochem Soc Trans30, 111-115. PubMed  Europe PubMed
58. Tremblay,G.M., Vachon,E., Larouche,C. and Bourbonnais,Y.
    Inhibition of human neutrophil elastase-induced acute lung injury in hamsters by recombinant human pre-elafin (trappin-2)
    Chest121, 582-588. PubMed  Europe PubMed DOI
59. Vachon,E., Bourbonnais,Y., Bingle,C.D., Rowe,S.J., Janelle,M.F. and Tremblay,G.M.
    Anti-inflammatory effect of pre-elafin in lipopolysaccharide-induced acute lung inflammation
    Biol Chem383, 1249-1256. PubMed  Europe PubMed DOI
60. [YEAR:29-1-2002]Zaidi,S.H., You,X.M., Ciura,S., Husain,M. and Rabinovitch,M.
    Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension
    Circulation105, 516-521. PubMed  Europe PubMed DOI
2001
61. Ying,Q.L. and Simon,S.R.
    Kinetics of the inhibition of proteinase 3 by elafin
    Am J Respir Cell Mol Biol24, 83-89. PubMed  Europe PubMed DOI
2000
62. Bourbonnais,Y., Larouche,C. and Tremblay,G.M.
    Production of full-length human pre-elafin, an elastase specific inhibitor, from yeast requires the absence of a functional yapsin 1 (Yps1p) endoprotease
    Protein Expr Purif20, 485-491. PubMed  Europe PubMed DOI  E
63. Cowan,K.N., Heilbut,A., Humpl,T., Lam,C., Ito,S. and Rabinovitch,M.
    Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor
    Nat Med6, 698-702. PubMed  Europe PubMed DOI
64. [YEAR:7-11-2000]O'Blenes,S.B., Zaidi,S.H.E., Cheah,A.Y.L., McIntyre,B., Kaneda,Y. and Rabinovitch,M.
    Gene transfer of the serine elastase inhibitor elafin protects against vein graft degeneration
    Circulation102 Suppl 3, 289-295. PubMed  Europe PubMed
1997
65. Francart,C., Dauchez,M., Alix,A.J. and Lippens,G.
    Solution structure of r-elafin, a specific inhibitor of elastase
    J Mol Biol268, 666-677. PubMed  Europe PubMed DOI
1996
66. Lundwall,A. and Ulvsback,M.
    The gene of the protease inhibitor SKALP/elafin is a member of the REST gene family
    Biochem Biophys Res Commun221, 323-327. PubMed  Europe PubMed DOI
67. [YEAR:10-9-1996]Tsunemi,M., Matsuura,Y., Sakakibara,S. and Katsube,Y.
    Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution
    Biochemistry35, 11570-11576. PubMed  Europe PubMed DOI  S
1994
68. Nara,K., Ito,S., Ito,T., Suzuki,Y., Ghoneim,M.A., Tachibana,S. and Hirose,S.
    Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed "cementoin"
    J Biochem115, 441-448. PubMed  Europe PubMed
1993
69. [YEAR:5-7-1993]Tsunemi,M., Matsuura,Y., Sakakibara,S. and Katsube,Y.
    Crystallization of a complex between an elastase-specific inhibitor elafin and porcine pancreatic elastase
    J Mol Biol232, 310-311. PubMed  Europe PubMed DOI
70. [YEAR:23-2-1993]Ying,Q.L. and Simon,S.R.
    Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin
    Biochemistry32, 1866-1874. PubMed  Europe PubMed
1991
71. Wiedow,O., Luademann,J. and Utecht,B.
    Elafin is a potent inhibitor of proteinase 3
    Biochem Biophys Res Commun174, 6-10. PubMed  Europe PubMed DOI
1990
72. [YEAR:5-9-1990]Wiedow,O., Schroder,J.M., Gregory,H., Young,J.A. and Christophers,E.
    Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence
    J Biol Chem265, 14791-14795. PubMed  Europe PubMed